Sarcoidosis is an idiopathic multisystemic disease that affects young to middle aged adults, with higher incidence in women. Although it may involve the breast parenchyma, primary sarcoidosis of very rare. It occurs less than 1% cases. In a differential diagnosis potentially be considered malignancy.We report case which was first clinical manifestation systemic 54-year-old woman who presented wide erythematous skin changes associated palpable induration. Considering fact physical examination...

To elucidate the role of metallothioneins (MTs) in pathomechanisms autoimmune CNS disorders we estimated expression MTs I+II and tissue concentrations Zn2+ Cu2+ brain, spinal cord (SC) liver during periods attacks remissions chronic relapsing experimental encephalomyelitis (CR-EAE). Disease was induced genetically susceptible Dark Agouti (DA) rats by subcutaneous injection bovine brain homogenate CFA. Control were treated with CFA or saline solution. The data, obtained clinical assessment,...

Metallothioneins (MTs) are small, cysteine-rich proteins which have been implicated in various forms of stress providing cytoprotective action against oxidative injury, DNA damage and apoptosis. Owing to their high affinity for physiological metals, such as zinc copper MTs also critical components regulatory involved cell growth multiplication, well the maintenance immune homeostasis. To elucidate role pathomechanisms autoimmune CNS disorders we estimated expression MT I+II content free Zn...

A torsion of the vermiform appendix with a mesoappendiceal lipoma is rare condition. It also cause acute abdomen, as such, condition diagnosed during surgery. This case report presents 70-year-old male patient lower right abdominal pain and signs abdomen an increased peripheral blood leukocyte count. An ultrasound examination revealed mass 9.6 cm2, which was suggested to be perityphlitic abscess. emergency operation indicated, had clinical abdomen. Laparotomy via pararectal incision caused...

Tissue disintegration after injury leads, in the endoplasmic reticulum (ER), to activation of adaptive pathways known as ER stress response. It is directed correction unfolded proteins and proteasome-dependent ER-associated degradation misfolded proteins, but induces also a rapid natural immunity, since resident heat shock protein-gp96 acts not only molecular chaperone, strong adjuvant, able cross-present antigenic peptides onto MHC class I or II pathways. Analyzing its potential role...

Breast carcinoma shows extensive clinical and molecular heterogenicity.Glycoprotein gp96 is considered a negative prognostic predictive factor.Controversy exists over the role of tumor lymphocytic infiltrates.The goal this study to illustrate differences in CD4+ CD8+ T-lymphocytes expression among all immunohistochemical groups breast relation course outcome disease.A retrospective observational was conducted through processing analysis 152 female patient tissue samples previously classified...

Environmental airborne pollution has been repeatedly shown to affect multiple aspects of brain and cardiopulmonary function, leading cognitive behavioral changes the pronounced inflammatory response in respiratory airways. Since cellular defense system important role might have stress proteins-metallothionein (MT)-I MT-II, which are involved sequestration dispersal metal ions, regulation biosynthesis activities zinc-dependent transcription factors, as well protection from reactive oxygen...

The authors have provided an in-depth review of the history saline and silicone gel–filled breast implants. In medicine, no devices been more scrutinized thoroughly studied than Although we as plastic surgeons recognize appreciate benefits that our patients derive from these devices, society a whole continues to remain skeptical. reasons for this are complex multifactorial but appear be fueled by media, oppositional organizations, several trial lawyers. Prior 1990, when gel implant...

Breast cancer (BC) is the most common malignancy to affect females. The first suggestions of BC and its treatment date back Ancient Egypt, 1500-1600 B.C. Throughout history, management has evolved from extensive radical mastectomy towards less invasive treatments. Radical was introduced by W.S. Halsted in 1894, involving resection breast, regional lymph nodes, pectoralis major minor. Despite mutiloperative lymphatic mapping concept sentinel node (SLN) biopsy (SLNB) have been developed. SLNB...

The severe remodeling of endometrial stroma during blastocyst adhesion and trophoblast invasion initiates at maternal-fetal interface the reaction evolutionary old heat shock response, in which proteins, as molecular chaperons, monitor configurations newly synthesized proteins prevent formation functionless aggregates misfolded targeting them to degradation by a ubiquitin-proteasome system. In addition, endoplasmic reticulum (ER)-resident HSPs, such gp96/GRP94 may, after binding CD91 TLRs,...

Glycoprotein 96 (gp96) is a member of the heat shock protein 90 family, which an ubiquitous family molecular chaperones that are involved in regulation folding and other essential cellular activities. Residing lumen endoplasmic reticulum, gp96 plays key role maintaining homeostasis, from assemblage to degradation. However, exposure stressful conditions disturb homeostasis may translocate cell surface, implies its additional functions, such as intracellular signalling, proliferation,...

Objectives: In this paper, we investigate the association of glycoprotein 96 (GP96) and androgen receptor (AR) expression with clinicopathological factors, additional axillary lymph node burden, their potential role in predicting 5-year overall survival (OS) disease-free (DFS) breast cancer (BC) patients sentinel (SLN) involvement. We also explore prognostic value presence extranodal extension (ENE) SLN. Methods: retrospectively enrolled 107 female cT1-T2 invasive BC positive SLN biopsy....

Hernia is characterized as the protrusion of peritoneum with or without an organ a portion through defect abdominal wall. It's likely that inguinal hernias have been problem since beginning human history. Many doctors had challenges in past when treating them. Although they are no longer recognized fatal illness, nevertheless very common general population and can be clinically complicated. There has advancement hernia repair throughout The biggest was late 1800s Eduardo Bassini published...

Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which involved in correction of unfolded proteins, activation proteasome-dependent ER-associated degradation misfolded and protein translation that modulates polypeptide traffic into ER. Furthermore, owing to its peptide chaperone capacity ability interact with professional antigen-presenting cells, as well growth factors, integrins Toll-like receptors, it also endowed crucial immunological functions acting a "danger...

Angiosarcomas are highly aggressive and malignant blood vessel tumors. Rarely, angiosarcomas develop in the breast following conservative therapy, namely radiotherapy.A 70-year-old female patient presented with dark purple discoloration of skin right breast. 6 years earlier, had undergone surgery for invasive ductal carcinoma According to breast-conserving protocol, been treated radiotherapy residual tissue. The patient's annual mammograms ultrasound findings were normal. lesion was...

Background: Although response-adjusted surgery is a highly recommended strategy following neoadjuvant systemic treatment (NAST), consensus on axillary management in cN+/ycN0 breast cancer patients still lacking. In this setting, clinical significance of the higher false negative rate sentinel lymph node biopsy (SLNB) procedure unknown. The present analysis aims to evaluate long-term safety SLNB ycN0 patients. Methods: study, 60 with operable cancer, undergoing after NAST Clinical Hospital...

BACKGROUND: Male breast cancer is a rare disease, accounting for 0,1% of all cancers in men and 0.6% to 1% cancers. The aim this paper present histopathological clinical features male at the Clinic Surgery, Clinical Hospital Centre Rijeka, Croatia, over 14-year period.METHODS: Between 2003 2017 twenty-seven underwent surgery our facility. Information retreived from patients’ records included stage histologic type, grade, hormone receptor status primary tumour, axillary lymph node...