A5031479972- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- Protist diversity and phylogeny
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- RNA Research and Splicing
- DNA Repair Mechanisms
- GDF15 and Related Biomarkers
- ATP Synthase and ATPases Research
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Genetics, Aging, and Longevity in Model Organisms
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Autism Spectrum Disorder Research
- Polyamine Metabolism and Applications
- RNA regulation and disease
- Peptidase Inhibition and Analysis
Harvard University
2021-2024
Dana-Farber Cancer Institute
2021-2024
Centre National de la Recherche Scientifique
2020
Centre de Biologie du Développement
2016-2020
Brandeis University
2020
Université Toulouse III - Paul Sabatier
2020
Google (United States)
2018
Institut de Pharmacologie et de Biologie Structurale
2016
Abstract IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease. Extracellular activates growing number of target cells, including group 2 innate lymphoid mast cells regulatory T but it remains unclear whether intracellular has additional functions nucleus. Here, we used global proteomic approach based on high-resolution mass spectrometry to compare extracellular primary human endothelial major source protein tissues. We found exogenous induced...
Microtubules are nucleated from multiprotein complexes containing γ-tubulin and associated complex proteins (GCPs). Small (γTuSCs) comprise two molecules of bound to the C-terminal domains GCP2 GCP3. γTuSCs associate laterally into helical structures, providing a structural template for microtubule nucleation. In most eukaryotes with additional GCPs (4, 5, 6) form core so-called ring (γTuRC). 2–6 constitute family homologous proteins. Previous analysis modeling suggest that all members can...
High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed that was enhanced cell migration in vitro invasive metastatic behavior murine xenografts. Sequence analysis the polyribosome fraction LIN28B-expressing cells revealed let-7–independent enrichment transcripts encoding components translational ribosomal apparatus depletion neuronal developmental programs. We further observed utilizes both...
ABSTRACT γ-Tubulin is the main protein involved in nucleation of microtubules all eukaryotes. It forms two different complexes with proteins GCP family (γ-tubulin complex proteins): γ-tubulin small (γTuSCs) that contain γ-tubulin, and GCPs 2 3; ring (γTuRCs) multiple γTuSCs addition to 4, 5 6. Whereas structure assembly properties have been intensively studied, little known about γTuRCs specific roles Here, we demonstrate copies GCP4 one copy each GCP5 GCP6 form a salt (KCl)-resistant...
Translation factors are essential for regulation of protein synthesis. The eukaryotic translation initiation factor 5A (eIF5A) family is made up two paralogues - eIF5A1 and eIF5A2 which display high sequence homology but distinct tissue tropism. While directly binds to the ribosome regulates initiation, elongation, termination, molecular function remains poorly understood. Here, we engineer an knockout allele in SW480 colon cancer cell line. Using profiling RNA-Sequencing, reveal that...
Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and attention-deficit hyperactivity disorder (ADHD). However, little known about the molecular mechanisms that protect against mitochondrial during neurodevelopment. Here, we address this question through investigation rbm-26, Caenorhabditis elegans ortholog RBM27 autism candidate gene, which encodes an RNA-binding protein whose role in neurons unknown. We...
Abstract γ-tubulin is a major protein involved in the nucleation of microtubules all eukaryotes. It forms two different complexes with proteins GCP family (gamma-tubulin complex proteins): small (γTuSCs), containing and GCPs 2 3, ring (γTuRCs), multiple γTuSCs, addition to 4, 5, 6. Whereas structure assembly properties γTuSCs have been intensively studied, little known about γTuRCs, specific roles Here, we demonstrate that copies GCP4 one copy each GCP5 GCP6 form salt-resistant sub-complex...
Abstract Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and ADHD. However, little known about the molecular mechanisms that protect against mitochondrial during neurodevelopment. Here, we address this question through investigation rbm-26 , C. elegans ortholog RBM27 autism candidate gene, which encodes an RNA-binding protein whose role in neurons unknown. We report RBM-26 (RBM26/27) protects axonal defects...