A5046400387- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Advanced Scientific Research Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Estrogen and related hormone effects
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Exercise and Physiological Responses
- RNA regulation and disease
- Neural dynamics and brain function
- Hormonal Regulation and Hypertension
Maj Institute of Pharmacology
2015-2025
Polish Academy of Sciences
2015-2025
German Cancer Research Center
2007-2013
Institute of Pharmacology
2011-2013
DKFZ-ZMBH Alliance
2013
Heidelberg University
2007-2013
Heidelberg University
2008
The nucleolus represents an essential stress sensor for the cell. However, molecular consequences of nucleolar damage and their possible link with neurodegenerative diseases remain to be elucidated. Here, we show that is present in both genders Parkinson's disease (PD) pharmacological PD model induced by neurotoxin 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine hydrochloride (MPTP). Mouse mutants disruption restricted dopaminergic (DA) neurons phenotypic alterations resemble PD, such as...
Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute wide range pomegranate's health benefits. While lot experimental studies have been devoted Alzheimer disease and hypoxic-ischemic brain injury, our knowledge effects against Parkinson's (PD) very limited. It suggested that its neuroprotective are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability pomegranate for protection PD in rat model parkinsonism induced rotenone. To...
Stress-evoked dysfunctions of the frontal cortex (FC) are correlated with changes in functioning glutamatergic system, and evidence demonstrates that noradrenergic transmission is an important regulator this process. In current study, we adopted a restraint stress (RS) model male Wistar rats to investigate whether blockade β1 adrenergic receptors (β1AR) betaxolol (BET) stressed animals influences body's response expression selected signaling proteins medial prefrontal (mPFC). The study was...
OPINION article Front. Hum. Neurosci., 02 November 2016Sec. Cognitive Neuroscience Volume 10 - 2016 | https://doi.org/10.3389/fnhum.2016.00556
Transcription of rRNA genes is essential for maintaining nucleolar integrity, a hallmark the healthy state and proliferation rate cell. Inhibition synthesis leads to disintegration nucleolus, elevated levels p53, induction cell suicide, identifying nucleolus as critical stress sensor. Whether deregulation causally involved in neurodegeneration by promoting death and/or inhibiting cellular growth has however not been addressed. The transcription factor TIF-IA plays central role mammalian...
Current investigations underline the important roles of C-C motif ligands in development neuropathic pain; however, their participation diabetic neuropathy is still undefined. Therefore, goal our study was to evaluate macrophage inflammatory protein-1 (MIP-1) family members (CCL3, CCL4, CCL9) a streptozotocin (STZ) induced mouse model pain. Single intrathecal administration each MIP-1 member (10, 100 or 500ng/5ul) naïve mice evoked hypersensitivity mechanical (von Frey test) and thermal...
L-3,4-Dihydroxyphenylalanine (L-DOPA) is effective at alleviating motor impairments in Parkinson's disease (PD) patients but has mixed effects on nonmotor symptoms and causes adverse after prolonged treatment. Here, we analyzed the spatial profile of L-DOPA-induced gene expression forebrain mice with an inducible progressive loss dopaminergic neurons (the TIF-IADATCreERT2 strain), a focus similarities differences areas relevant to different PD symptoms. The animals received 14-day L-DOPA...
We investigated whether the functional involvement of α1-adrenergic receptors (α1-AR) in effects induced by antidepressant drugs, desipramine, and milnacipran varies depending on α1-AR subtype. First, using a mouse line with triple knockout (KO) genes encoding all three subtypes (ABD-KO) autoradiographic analysis, we demonstrated that inactivation did not affect density other types adrenergic receptors, α2- β-AR brain. Subsequently, utilized lines selective gene single receptor subtype...
Abstract Background Recent studies indicated the involvement of some chemokines in development diabetic neuropathy; however, participation chemokine-C-motif ligand (XCL) subfamily remains unknown. The goal this study was to examine how microglial inhibition by minocycline hydrochloride (MC) influences 1 (XCL1)–chemokine-C-motif receptor (XCR1)/G protein–coupled 5 expression and allodynia/hyperalgesia streptozotocin-induced neuropathy. Methods were performed on streptozotocin (200 mg/kg,...
Recently, the role of CXCR2 in nociception has been noted. Our studies provide new evidence that intrathecal administration its CINC ligands (Cytokine-Induced Neutrophil Chemoattractant; CXCL1-3) induces pain-like behavior naïve mice, and effect occurring shortly after is associated with neural location CXCR2, as confirmed by immunofluorescence. RT-qPCR analysis showed, for first time, raised levels spinal chronic constriction injury (CCI) sciatic nerve rats. Originally, on day 2, we...
Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, participation its two receptors, canonical receptor (XCR1) and integrin alpha-9 (ITGA9), recently recognized as a second receptor, has not been clarified to date. The aim was explore by which these receptors XCL1 reveals pronociceptive properties how XCL1-XCR1 XCL1-ITGA9 axes blockade/neutralization influence on pain-related behavior opioid analgesia model neuropathic...
Decreased rRNA synthesis and nucleolar disruption, known as stress, are primary signs of cellular stress associated with aging neurodegenerative disorders. Silencing rDNA occurs during early stages Alzheimer's disease (AD) may play a role in dementia. Moreover, aberrant regulation the protein machinery is present brain suicide victims implicates epigenetic modulation rRNA. Recently, we developed unique mouse models characterized by neurons. We inhibited RNA polymerase I genetic ablation...
The aim of this study was to investigate whether conditional inactivation the glucocorticoid receptors (GRs) in noradrenergic neurons affects animal behavior mice. Selective ablation GRs system achieved using Cre/loxP approach. We crossed transgenic mice expressing Cre recombinase under dopamine beta-hydroxylase (DBH) promoter with animals harboring floxed GR gene. resulting GR(DBHCre) mutant exhibited no alterations terms normal cage behavior, weight gain, spatial memory or spontaneous...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder and characterized by motor deficits such as tremor, rigidity bradykinesia. These symptoms are directly caused loss of dopaminergic neurons. However, a wealth clinical evidence indicates that system not only affected in PD. Postmortem studies brains from PD patients have revealed degeneration noradrenergic neurons locus coeruleus (LC) to same or even greater extent than observed substantia nigra (SN)...
Parkinson’s disease (PD) is characterized by three main motor symptoms: bradykinesia, rigidity and tremor. PD also associated with diverse non-motor symptoms that may develop in parallel or precede dysfunctions, ranging from autonomic system dysfunctions impaired sensory perception to cognitive deficits depression. Here, we examine the role of progressive loss dopaminergic transmission behaviors related a mouse model (the TIF-IA DATCreERT2 strain). We found period 5 12 weeks after induction...