A5062903372- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Cellular transport and secretion
- Retinal Imaging and Analysis
- Advanced Glycation End Products research
- Photoreceptor and optogenetics research
- Glaucoma and retinal disorders
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Spaceflight effects on biology
- Muscle activation and electromyography studies
- Hemispheric Asymmetry in Neuroscience
- Motor Control and Adaptation
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Diabetes Management and Research
- Coral and Marine Ecosystems Studies
- Vagus Nerve Stimulation Research
- Biomedical Research and Pathophysiology
- Heat shock proteins research
- Renin-Angiotensin System Studies
- Anesthesia and Neurotoxicity Research
West Virginia University
2019-2025
Hospital Costa del Sol
2019
National Technological University
2017
University of Buenos Aires
2005-2014
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2013
Abstract Diabetic retinopathy ( DR ) is a leading cause of acquired blindness in adults, mostly affected by type 2 diabetes mellitus T DM ). We have developed an experimental model early adult rats which mimics some features human at its initial stages and provokes significant retinal alterations. The aim this work was to analyze the effect melatonin on changes induced moderate metabolic derangement. For purpose, male Wistar received control diet or 30% sucrose drinking water. Three weeks...
Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to photoreceptor impairment and vision loss. To determine role of development, function, maintenance ciliated photoreceptors, we generated a pan-retina knock-out (Six3-Cre) rod photoreceptor-specific inducible conditional (Pde6g-CreERT2) using murine models. Embryonic deletion led defects retinal development with reduced cell proliferation. In absence ARL13B, photoreceptors failed develop outer segment (OS)...
Background/Objectives: The interphotoreceptor matrix proteoglycans 1 and 2 (IMPG1 IMPG2) are two interdependent of the (IPM). Mutations in IMPG1 or IMPG2 linked to retinal diseases such as retinitis pigmentosa (RP) vitelliform macular dystrophy (VMD), yet specific mutations responsible for each condition remain undefined. This study identifies either RP VMD. It also provides an in-depth silico analysis these mutations’ structural functional impact on protein domains, alongside a detailed...
Glaucoma is a leading cause of blindness worldwide, characterized by retinal ganglion cell degeneration and damage to the optic nerve. We investigated non-image forming visual system in an experimental model glaucoma rats induced weekly injections chondroitin sulphate (CS) eye anterior chamber. Animals were unilaterally or bilaterally injected with CS vehicle for 6 10 weeks. In retinas from eyes CS, similar decrease melanopsin Thy-1 levels was observed. number melanopsin-containing cells...
Photoreceptor neurons are surrounded by an extracellular matrix, called the interphotoreceptor matrix (IPM). Activities crucial to vision occur within IPM, including trafficking of nutrients and metabolites, retinal attachment, interactions needed for normal outer segment phagocytosis. The IPM includes following two unique proteoglycans: proteoglycan 1 (IMPG1) IMPG2. Patients with mutations in IMPG1/IMPG2 develop visual deficits subretinal material accumulation, highlighting critical role...
Heat shock protein 90 (HSP90) is an abundant molecular chaperone that regulates the stability of a small set proteins essential in various cellular pathways. Cytosolic HSP90 has two closely related paralogs: HSP90α and HSP90β. Due to structural sequence similarities cytosolic paralogs, identifying unique functions substrates cell remains challenging. In this article, we assessed role retina using novel murine knockout model. Our findings show for rod photoreceptor function but was...
Retinal ischemia could provoke blindness. At present, there is no effective treatment against retinal ischemic damage. Strong evidence supports that glutamate implicated in We investigated whether a brief period of global or ocular hypothermia applied 24 h before (i.e. hypothermic preconditioning, HPC) protects the retina from ischemia/reperfusion damage, and involvement protection induced by HPC. For this purpose, was increasing intraocular pressure to 120 mm Hg for 40 min. One day...
The interphotoreceptor matrix (IPM) is a specialized extracellular mesh of molecules surrounding the inner and outer segments photoreceptor neurons. Interphotoreceptor proteoglycan 1 2 (IMPG1 IMPG2) are major components IPM. Both proteoglycans possess SEA (sperm protein, enterokinase agrin) domains, which may support proteolysis. Interestingly, mutations in domains IMPG1 IMPG2 associated with vision disease humans. However, if IMPG undergo proteolysis, how this contributes to pathology...
It has been established that neurosteroids can either inhibit or enhance GABA(A) receptor activity. Although GABA is the main inhibitory neurotransmitter in mammalian retina, effects of on retinal GABAergic activity have not investigated. The aim this work was to study neurochemical and electroretinographic golden hamster. On one hand, pregnenolone sulfate inhibited allotetrahydrodeoxycorticosterone increased GABA-induced [36Cl]- uptake neurosynaptosomes. other whole retinas, increased,...
Abstract Complex movements such as walking or reaching are generated by a sequence of muscle actions. How these coordinated actions subserve complex and their recovery after disruption remains unknown. The use high throughput recording-stimulation systems with microelectrode access to structures along the neuraxis may complement neurological models in rodents. To this purpose, we have trained rats perform precise foot placement locomotor task that allows us assess skilled movements. Animals...