A5013999767- Mycotoxins in Agriculture and Food
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Plant Disease Resistance and Genetics
- Veterinary medicine and infectious diseases
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
- Pharmacological Effects of Medicinal Plants
- Moringa oleifera research and applications
- Viral Infectious Diseases and Gene Expression in Insects
- Fatty Acid Research and Health
- Wheat and Barley Genetics and Pathology
- Alcohol Consumption and Health Effects
- Genomics, phytochemicals, and oxidative stress
- Milk Quality and Mastitis in Dairy Cows
- Insect and Pesticide Research
- Rabbits: Nutrition, Reproduction, Health
- Immune Response and Inflammation
- Meat and Animal Product Quality
- Nephrotoxicity and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
Institute for Diagnosis and Animal Health
2021-2024
National Research Development Institute for Animal Biology and Nutrition
2011-2016
The toxicity of zearalenone (ZEA) was evaluated in swine spleen, a key organ for the innate and adaptative immune response. Weaned pigs were fed 18 days with control or ZEA contaminated diet. effect assessed on wide genome expression, pro- (TNF-α, IL-8, IL-6, IL-1β, IFN-γ) anti-inflammatory (IL-10, IL-4) cytokines, other molecules involved inflammatory processes (MMPs/TIMPs), as well signaling molecules, (p38/JNK1/JNK2-MAPKs) nuclear receptors (PPARγ/NFkB/AP-1/STAT3/c-JUN). Microarray...
The intestinal epithelium is the first barrier against food contaminants. Zearalenone (ZEN) an estrogenic mycotoxin that was identified as a common contaminant of cereal grains and feedstuffs. In present study, we have investigated in vitro effects ZEN some its metabolites (α-ZOL, β-ZOL) concentrations 10-100 µM on swine epithelial cell line: Intestinal porcine cells (IPEC-1). We demonstrated both were more toxic for IPEC resulted from XTT test, while doses lower than 10 µM, only β-ZOL...
African swine fever (ASF) is a highly contagious and severe haemorrhagic disease of Suidae, with mortalities that approach 100 percent. Several studies suggested the potential implication non-biting dipterans in spread ASFV pig farms due to identification DNA. However, our knowledge, no study has evaluated viral DNA load collected outbreak risk factors have been analysed. In this context, aimed analyse associated presence from ASF outbreaks relation
Camelina oil-cakes results after the extraction of oil from sativa plant. In this study, camelina were fed to fattening pigs for 33 days and its effect on performance, plasma biochemical analytes, pro-/anti-inflammatory mediators antioxidant detoxifying defence in spleen was investigated comparison with sunflower meal. 24 crossbred TOPIG randomly assigned one two experimental dietary treatments containing either 12% meal (treatment 1-T1), or 12.0% oil-cakes, rich polyunsaturated fatty acids...
Plants and plant extracts (PPEs) have gained increasing interest as feed additives possible replacing antibiotics for pig productions. The effects of dietary Chlorella vulgaris (1%), sodium alginate (0.1%), inulin (1.5%), a mixture essential oils (0.04%) supplements on immune response, bioavailability some micronutrients (iron - Fe, copper Cu, manganese Mn, zinc Zn) were investigated in weaned piglets this study. results showed that the concentration IgG was increased plasma pigs fed PPEs...
The gastrointestinal tract is the primary site of toxin interaction, an interface between organism and its surroundings. In this study, we assessed alteration intestinal mRNA profile in case co-occurrence zearalenone (ZEA), a secondary Fusarium metabolite, Escherichia coli (E. coli), on porcine epithelial cells IPEC-1. We chose model since pig species which susceptible to pathogen mycotoxin co-exposure. After treating with two contaminants, either separately or combination, differential gene...
Trichotecenes are mycotoxins produced by Fusarium sp., which may contaminate animal feeds and human food. A feeding trial was conducted to evaluate the effect of a fusarotoxin-contaminated diet, explore counteracting potential calcium fructoborate (CFrB) additive on performance, typical health biochemistry parameters immune response in weaned pigs. naturally contaminated maize, containing low doses deoxynivalenol, zearalenone, fumonisins T-2/HT-2 toxins (1790, 20, 0·6 90 parts per billion),...
Mechanical transmission of African swine fever virus (ASFV) has been investigated on few occasions, with Stomoxys calcitrans experimentally shown to transmit ASFV which was detected in various body parts for 3 days after infection. However, up date, there is no field evidence demonstrating the presence viral DNA blood-feeding arthropods. For this purpose, 30 pig farms from Romania where ASF confirmed were selected sampling according a risk scoring system. In 9 farms, pigs still present at...
Ochratoxins, are toxic fungal metabolites produced by certain moulds of the genera Aspergillus and Penicillium that grow on a wide range raw food commodities. The most relevant toxin is ochratoxin A (OTA) European Commission has established guidance values for OTA concerning complementary complete feeding stuff recommending pigs maximum concentration 0.05 mg/kg. These represent only recommendation establishment legal regulation needs additional toxicological data generated from farm animal...
African swine fever (ASF) is a contagious viral disease of that causes significant economic damage. The summer peaks and river courses have triggered the hypothesis vectors may be involved in transmission virus. In temperate climates, insect numbers increase late summer. Low temperatures frosts decrease number active insects. Their presence strongly associated with nearby wetlands or swamps around farms. aim our study was to evaluate risk factors ASFV DNA hematophagous dipterans analyze...
African swine fever (ASF) is a highly contagious viral disease of suids that causes significant economic damage. The summer peaks and river courses have triggered the hypothesis vectors may be involved in transmission virus. aim our study was to evaluate risk factors associated with presence ASFV DNA hematophagous dipterans analyze relevance Ct values positive samples ASF outbreaks Romania, as an indication for load. current included 99 pools stable flies ( Stomoxys calcitrans ) 278 biting...
OchratoxinA (OTA) and aristolochid acid (AA) effects on cell viability cytokine synthesis was analysed in an intestinal epithelial porcine line.The highest doses of AA OTA (>1μg/mL) induce a signi icant (P<0.05)decrease the viability.OTA has little or no effect IL-8 were induced decrease TNF alpha IL-1 beta.