A5044831373- Blood transfusion and management
- Iron Metabolism and Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Maternal and fetal healthcare
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Blood donation and transfusion practices
- Climate Change and Health Impacts
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Inflammatory Biomarkers in Disease Prognosis
- Electrolyte and hormonal disorders
- Appendicitis Diagnosis and Management
- Neonatal Respiratory Health Research
- Healthcare Policy and Management
- Respiratory Support and Mechanisms
- Artificial Intelligence in Healthcare and Education
- Anesthesia and Neurotoxicity Research
Lyell McEwin Hospital
2015-2025
The University of Adelaide
2014-2024
Health Net
2022
Women's and Children's Hospital
2017-2018
Objective: To determine if preoperative intravenous (IV) iron improves outcomes in abdominal surgery patients. Summary Background Data: Preoperative deficiency anemia (IDA) occurs frequently; however left untreated, increases the risk of blood transfusion allogeneic (ABT). Limited evidence supports IDA treatment with IV iron. This randomized controlled trial aimed to whether perioperative reduced need for ABT. Methods: Between August 2011 and November 2014, 72 patients were assigned receive...
Iron deficiency is a common nutritional amongst women of childbearing age. Peri-partum iron anaemia (IDA) associated with significant maternal, fetal and infant morbidity. Current options for treatment are limited: these include oral supplementation, which can be ineffective poorly tolerated, red blood cell transfusions, carry an inherent risk should avoided. Ferric carboxymaltose new option that may better tolerated. The study was designed to assess the safety efficacy correction...
Objective: To compare oral iron to intravenous administration women in late pregnancy and/or after labor correct deficiency.Methods: 271 anemic (148 pregnant and 123 post lower segment caesarean section) with hemoglobin (Hb) levels below 110 g/L were enrolled over a two-year period randomized receive either two tablets FGF (ferrous sulfate folic acid) or 400 mg of sucrose plus acid 600 µg. Treatment effectiveness was assessed by measuring Hb ferritin postpartum on day 1, 14 42. Transfusions...
More than 30% of the world's population are anemic with serious medical and economic consequences. Red blood cell transfusion is mainstay to correct anemia, but it also one top five overused procedures carries its own risk cost burden. Patient management (PBM) a patient-centered multidisciplinary approach manage minimize iatrogenic loss, harness tolerance anemia in an effort improve patient outcome. Despite resolution 63.12 World Health Organization 2010 endorsing PBM current guidelines...
To evaluate the efficacy and safety of intravenous ferric carboxymaltose administration to pregnant women with varying severities iron deficiency anemia without anemia.In this prospective observational study local obstetric practice, we analyzed data from 863 according status severity. All were treated in pregnancy. Treatment was assessed by repeat hemoglobin measurements at 3 6 week post-infusion ferritin levels, where available. Safety analysis adverse events, fetal heart rate monitoring,...
Perioperative administration of ferric carboxymaltose (FCM) was previously shown to reduce both the need for transfusions and hospital length stay in patients with preoperative iron deficiency anemia (IDA). In this study, we estimated economic consequences perioperative using FCM vs usual care IDA from perspective a German decision-analytic modeling.The model populated clinical inputs (transfusion rates, blood units transfused, stay) reported randomized trial comparing managing undergoing...
Maternal death from obstetric haemorrhage remains a common cause of maternal mortality worldwide1. Iron deficiency and iron-deficiency anaemia (IDA) in pregnancy is global health problem affecting around 20% women the western world increasing to 56% developing countries2. It associated with adverse physiological psychological outcomes both mother3,4 child5,6 (Table I). Iron-deficient are also at increased risk requiring an allogeneic red blood cell (RBC) transfusion during peri-partum...
Nitrous oxide is commonly used in Australia for labour analgesia. Its use potentially associated with aerosol generation. During the first wave of COVID-19 pandemic 2020, nitrous was suspended on many birthing units to reduce risk transmission. We aimed determine impact withholding analgesia, during pandemic, epidural rates, opioid analgesia use, and maternal neonatal outcomes. Withholding did not alter rates but significantly increase use. Caesarean section post-partum blood loss APGAR...
To test the equivalence of two doses intravenous iron (ferric carboxymaltose) in pregnancy.Parallel, two-arm randomised controlled trial with an margin 5%.Single centre Australia.278 pregnant women deficiency.Participants received either 500 mg (n = 152) or 1000 126) ferric carboxymaltose second third trimester.The proportion participants requiring additional (500 mg) to achieve and maintain ferritin >30 microg/L (diagnostic threshold for deficiency) at 4 weeks post-infusion, 6 weeks, 3-, 6-...
Abstract Purpose Intraoperative cell salvage is central to Patient Blood Management including for lower segment caesarean section. Prior April 2020, we initiated intraoperative during section based on risk assessment hemorrhage and patient factors. As the pandemic broadened, mandated prevent peri-partum anemia potentially reduce blood product usage. We examined association of routine maternal outcomes. Methods conducted a single-center non-overlapping before-after study obstetric patients...
Cell salvage is a key part of patient blood management. Different techniques are available for salvaging blood. A new intra-operative autotransfusion filter system became reinfusion unwashed whole Concern exists regarding whether this technique induces coagulation disturbances, offsetting the benefits autologous This study was designed to investigate content intra-operatively salvaged filtered and its impact after on clot formation in patients undergoing primary hip arthroplasty.