A5010609717- DNA Repair Mechanisms
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Helicobacter pylori-related gastroenterology studies
- Pediatric health and respiratory diseases
- Digestive system and related health
- Blood disorders and treatments
- Celiac Disease Research and Management
- T-cell and B-cell Immunology
- Empathy and Medical Education
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
Peoples' Friendship University of Russia
2023-2024
Research Centre for Medical Genetics
2021-2024
Moscow Clinical Scientific Center
2021-2023
Abstract Substantial background level of replication stress is a feature embryonic and induced pluripotent stem cells (iPSCs), which can predispose to numerical structural chromosomal instability, including recurrent aberrations Chromosome 12. In differentiated cells, stress-sensitive genomic regions, common fragile sites, are widely mapped through mitotic chromosome break induction by mild Aphidicolin treatment, an inhibitor replicative polymerases. IPSCs exhibit lower apoptotic threshold...
Evaluation of the clinical characteristics in patients with COVID-19. The article presents and instrumental data 1169 included a single-center mixed study. Patients were tested for COVID-19 using polymerase chain reaction, computed tomography (CT), antibody screening. Clinical history collected. In confirmed COVID-19, lung damage positive test antibodies observed 75.5 45.2% cases, respectively. most common symptoms were: fever (73.2%), weakness, (72.7%) dry cough (62.8%) shortness breath...
Replication stress is a feature of embryonic and induced pluripotent stem cells (iPSCs) predispose to chromosomal instability. We characterized the mitotic entry dynamics asynchronous iPSCs under replication mapped FRA12L fragile site in large neuronal ANKS1B gene. Our study provides first evidence common induction reveals potential somatic instability clinically relevant
Common variable immunodeficiency (CVID) is one form of the primary immunodeficiencies (PIDs). CVID characterized by clinical manifestations. Genetic alteration a cause disease in many cases. In current paper we described Patient N 45 years old, who have been suffering from frequent various infections and therefore attended an immunologist geneticist. Immunoglobulins (Ig) A, M, G deficiency was found patient. As result medical genetic counselling has suggested as diagnosis. Further molecular...