A5015951581- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Inflammatory Bowel Disease
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- CNS Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Hematological disorders and diagnostics
- Vascular Tumors and Angiosarcomas
- Cancer Mechanisms and Therapy
- COVID-19 and healthcare impacts
- Complement system in diseases
- Body Contouring and Surgery
- Iron Metabolism and Disorders
- Retinoids in leukemia and cellular processes
- Parvovirus B19 Infection Studies
- Histone Deacetylase Inhibitors Research
- Cutaneous lymphoproliferative disorders research
Moscow Clinical Scientific Center
2017-2025
Pirogov Russian National Research Medical University
2016-2025
Mental Health Research Center of Russian Academy of Medical Sciences
2017
City Clinical Hospital
2016
Russian Children's Clinical Hospital
2016
Regional Clinical Research
2014
Moscow Regional Research Institute of Obstetrics and Gynecology
2008-2013
Aim. To study the efficacy and safety of prophylactic single administration a fixed dose Extimia® (INN: empegfilgrastim) daily filgrastim in patients with HIV infection lymphoproliferative diseases (LPD) receiving chemotherapy (CT). Materials methods. The article presents results retrospective analysis medical records for 2022. criteria inclusion were diagnosis LPD use granulocyte colony-stimulating factor (G-CSF). Thirty relevant selected from archive. All received CT, including high-dose...
Background. The incidence of venous thromboembolic complications (VTEC) in patients with inflammatory bowel diseases is approximately 3 times higher than the general population and leads to a 2-fold increase risk mortality. VTEC highest during patient's hospital stay. Aim. To compare overall inpatients ulcerative colitis (UC) without primary prevention. Materials methods. In 2020, anticoagulant therapy was used for UC case acute thrombosis, 2022, thromboprophylaxis moderate high based on...
Background. Inflammatory bowel diseases (IBD) are characterized by chronic immune inflammation of the mucous membrane and/or thickness intestinal wall, and also accompanied disorders blood clotting system development a hypercoagulation state. Aim. To identify frequency thromboembolic complications (TEC) in IBD patients to determine influence acquired inherited factors that contribute TEС. Materials methods. The clinical status 1,238 who were treated 2019 was evaluated. Of these, 748 with...
Vascular endothelial growth factors (VEGFs) are angiogenic playing a key role in tumor development. VEGFs produced by different normal and cells, including platelets, lymphocytes mononuclear cells of peripheral blood. VEGF (VEGF-A, VEGF-C VEGF-D) VEGFR (VEGFR1, VEGFR2 VEGFR3) gene expression was studied patients with myelodysplastic syndrome (MDS) to evaluate the possible prognostic these genes. Gene levels were determined using blood samples 51 MDS 15 healthy volunteers quantitative PCR....
Myelodysplastic syndrome (MDS) is a clonal disease derived from hematopoietic stem cells, characterized by ineffective hematopoiesis (resulting in peripheral blood cytopenia) and an increased risk of transformation into acute myeloid leukemia. MDS caused complex combination genetic mutations resulting heterogeneous genotype. Genetic studies have identified set aberrations that play central role the pathogenesis MDS. In this article, we present clinical case leukemia context two cell lines...
Background/Aim: Myelodysplastic syndromes (MDS) are clinically heterogeneous hematological malignancies with an increased risk of transformation to acute myeloid leukemia, emphasizing the importance identifying new diagnostic and prognostic markers. This study sought investigate predictive ability all-trans retinoic acid (ATRA)-dependent nuclear transcription factors RARα PPARβ/δ gene expression in MDS patients. Materials Methods: Peripheral blood specimens were collected from 49 patients 15...
Aim. To evaluate the acute myeloid leukemia (AML) treatment efficacy in adults Moscow real clinical practice according to Cancer Registry data. Materials and methods. We retrospectively collected data from on permanent residents who were primary diagnosed with AML January 2019 November 2023. The effectiveness of antitumor therapy was assessed by complete remissions rate, relapses, deaths, 3-year overall relapse-free survival. Data analysis performed as 01.12.2023. Results. According...
Aim. To evaluate the efficacy and safety profile of BvB combination in treatment R/R nPTCL, complete response (CR) partial (PR) rates, overall survival (OS), progression-free (PFS). Materials methods. The analysis included 39 patients with forms nPTCL who underwent state budgetary institutions Moscow Department Health (06.2008–08.2024). (CR, PR, OS, PFS) were evaluated. Results. best was noted when regimen prescribed as a 2nd-line therapy compared to 3rd subsequent lines. rate (ORR) 57%...
Background . Data from real-life clinical practice studies provide additional information on the efficacy of new antitumor therapy regimens, including in patients who meet exclusion criteria for trials. Aim To evaluate Isaomex triplet multiple myeloma real practice. Materials and methods From 2021 to 2024, retrospective study included 83 double refractory 26 centers aged 38 85 years (median 63), received triplet. Glomerular filtration rate ˂ 60 mL/min was detected at time isatuximabbased...
The authors give their own data in the first Russian publication on 170 patients with lymphomas and hepatitis concurrent HIV infection, distribution of therapy regimens by nosological entities number deaths. Conventional protocols programs were used for diagnosis treatment. All received highly active antiretroviral therapy. Lymphoma was treated according to conventional using rituximab people without B. Aggressive lymphomas, such as diffuse large B-cell lymphoma, Burkitt plasmablastic...
We have investigated the frequencies of regulatory T cells and level FOXP3 isoforms expression in peripheral blood patients with myelodysplastic syndromes found significant reduction at all stages disease. At same time untreated patients, we observed shift profile towards full-length molecule possibly due to inflammation. Based on already known information about potentially higher functional activity lacking exon 2, also hypothesized that our finding may explain high risk autoimmune disorders this
A steady worldwide increase in the number of people living with HIV (PLHIV) and diagnostic methods requires a separate review patient-specific nosologies, including lymphoproliferative diseases, some which are directly associated virus due to its oncogenic effect those that do not relate but introduce nuances therapeutic approaches when patient is HIV-positive. Towards this, paper generally reviews lymphomas PLHIV, presents WHO classification HIV-associated lymphomas, describes contemporary...
Evaluation of the clinical characteristics in patients with COVID-19. The article presents and instrumental data 1169 included a single-center mixed study. Patients were tested for COVID-19 using polymerase chain reaction, computed tomography (CT), antibody screening. Clinical history collected. In confirmed COVID-19, lung damage positive test antibodies observed 75.5 45.2% cases, respectively. most common symptoms were: fever (73.2%), weakness, (72.7%) dry cough (62.8%) shortness breath...
To assess the significance of gene expression vascular endothelial growth factor-A (VEGF-A) and its interacting receptors VEGFR1 VEGFR2 as potential diagnostic prognostic molecular markers in patients with myelodysplastic syndrome (MDS).A real time polymerase chain reaction (RT-PCR) assay was used to investigate VEGF-A, VEGFR1, mononuclear cell fractions obtained from 24 MDS.The 3 genes identified all examined. There highest level VEGF-A (p<0.0001), whereas higher than that (p<0.001). The...
Continuous red blood cell (RBC) transfusions are the main factor of hemosiderosis development, but many Myelodysplastic syndrome (MDS) patients develop iron overload at an early stage disease before begin. Hepsidin is a hormone, produced by hepatocytes. It plays leading role in hemostasis. MDS demonstrate elevated serum ferritin and hepcidin concentrations even RBC initiating. After 6 months follow-up, concentration was increased up to 1278 µg/L without significant elevation. 12 months,...
We present a clinical case of 24-year old female patient who was hospitalized with high active ulcerative colitis associated latent hereditary thrombophilia uncontrolled due to the exacerbation and local steroid treatment. The treated combination systemic steroids, adalimumab anticoagulants. emphasize necessity multidisciplinary approach her demonstrates possibility safe use anticoagulants prevent thromboembolic complications in patients risk thrombus formation, under careful monitoring...
Paroxysmal nocturnal hemoglobinuria (PNH) is a systemic, acquired clonal hematological disorder which results from loss of complement-inhibiting proteins (CD55 and CD 59) the blood cell surface.Therefore, such patients develop chronic complement-mediated intravascular hemolysis, with thromboses manifesting as most severe clinical complications.Recommendations International PNH groups discern certain risk based on detection pathological clone, including myelodysplastic syndrome (MDS).Here we...
Patients with inflammatory bowel disease (IBD) showed more frequent development of thromboembolic complications, compared the general population. The aim was to identify changes in haemostatic system patients ulcerative colitis (UC), depending on degree activity disease. study included 15 total lesions, who were divided into three groups, Mayo scale. first group remission, second UC had moderate disease, third high activity. state blood coagulation assessed by method extended coagulogram...