A5103167732- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Peripheral Neuropathies and Disorders
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Research on Leishmaniasis Studies
- Hematological disorders and diagnostics
- Bone health and treatments
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diabetes and associated disorders
- Hereditary Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- vaccines and immunoinformatics approaches
- HER2/EGFR in Cancer Research
- Parathyroid Disorders and Treatments
- MRI in cancer diagnosis
- 14-3-3 protein interactions
- Chemokine receptors and signaling
Ministry of Health of the Russian Federation
2019-2025
National Research Center for Hematology Russian Academy of Medical Sciences
2015-2024
S. M. Kirov Military Medical Academy
2019
Universidad de Salamanca
2019
Background. Anemia is the main symptom of multiple myeloma (MM) both at time disease onset and during tumor progression. Previously, method anemia treatment was blood transfusion therapy. Currently, transfusions are supplemented by erythropoietin (EPO) administration. Safety effectiveness drug have been proven in trials including involving oncohematological patients. Aim. To present results using epoetin alpha (Eralfon) patients with MM complicated dialysis-dependent cast nephropathy real...
Background. One of the most common causes peripheral neuropathy in multiple myeloma patients is bortezomib‑induced (bIpN), which clinically characterized by paresthesia, a burning sensation, numbness, and primarily pain limbs. This syndrome often associated with development anxiety depression. Aim. To study BIPN determine relationship between mental disorders descriptors at completion stage induction therapy after autologous hematopoietic stem cell transplantation (auto‑HSCT). Materials...
Multiple myeloma (MM) is a disease characterized by spatiotemporal heterogeneity of tumor clones. Different genetic aberrations can be observed simultaneously in cells from different loci, and as the progresses, new subclones may appear. The role liquid biopsy, which based on analysis DNA circulating blood plasma, continues to explored MM. Here, we present an STR profiles mutation status KRAS, NRAS, BRAF genes, evaluated plasma free (ctDNA), CD138+ bone marrow cells, plasmacytomas....
Background . Multiple myeloma complicated by extramedullary plasmacytoma is an unfavorable variant of the disease. It remains unknown what triggers tumor transformation. The review presents literature data on pathogenesis disease, as well a clinical example comprehensive study substrate. Aim To molecular and biological characteristics substrate bone marrow using various research methods. Materials methods A 55-year-old patient was admitted to National Medical Research Center for Hematology...
Multiple myeloma (MM) is characterized by heterogeneity of tumor cells. The study cells from blood, bone marrow, plasmacytoma, etc., allows us to identify similarities and differences in lesions various anatomical localizations. aim this was compare the loss heterozygosity (LOH) assessing STR profiles different MM lesions. We examined paired samples plasma circulating DNA (ctDNA) CD138+ marrow patients. For patients with plasmacytomas (66% 38 included), profile also studied when biopsy were...
Supportive therapy is becoming increasingly important for the state-of-the-art algorithm of multiple myeloma (MM) treatment. The introduction innovative drugs and transplantation methods into clinical practice considerably improved disease-free overall survival rates. However, in vast majority cases, MM still remains an incurable malignant plasma cell tumor. It often treated on a continuous basis with succession targeted integration glucocorticosteroids conventional cytostatic agents program...
Aim.To assess the safety and efficacy of autologous haematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients with dialysis-dependent renal failure. Materials methods.During a period from May 2010 to December 2016 fourteen MM failure aged 48 65 years underwent auto-HSCT. After induction therapy complete response, very good partial response were documented 64, 29, 7% patients, respectively. In no case was achieved. Haematopoietic mobilization most (13/14)...
Aim. To study immunohistochemical parameters of tumor plasma cells in bone marrow and to assess how the expression adhesion molecule CD56 impacts overall survival (OS) multiple myeloma (MM) patients. Materials & Methods. The trial included 35 patients (19 men 16 women) aged 23 73 years (with median age 58 years) with newly diagnosed MM. At disease onset plasmacytoma was 21 In all core biopsy performed followed by histologic (IHC) examinations. IHC examination based on panel CD56, CD166,...
AIM. To identify the KRAS and NRAS gene mutations in patients with newly diagnosed multiple myeloma (ММ) to classify them according depth of antitumor response bortezomib-based triplet induction therapy. MATERIALS & METHODS. The trial enrolled 89 MM prior chemotherapy. Among them, there were 45 women 44 men aged 30–82 years (median 58.5 years). ММ was IMWG criteria (2014). Bone marrow (BM) plasma cells isolated from aspirate using gradient method subsequent immunomagnetic CD138 marker...
Background. One of the most common symptoms multiple myeloma (MM) is pain. Bone pain observed in 60– 80 % patients at disease onset. Neuropathic syndrome also often found MM. Aim. To characterize MM onset and various therapy stages. Materials methods. From January 2019 to October 2021 a retrospective single-center study included 105 with newly diagnosed symptomatic (49 men, 56 women) aged from 26 83 years (median 58.5). Induction all was performed bortezomib-containing regimens. High-dose...
BACKGROUND. Cardiac amyloidosis is a serious progressive disease with high mortality rate. Differentiation between AL and ATTR types of critically important for choosing the optimal treatment. AIM. This study aims to evaluate capabilities cardiac MRI in differential diagnosis amyloidosis. METHODS. A retrospective analysis medical data from 25 patients confirmed (12 13 ATTR) was conducted. These underwent contrast-enhanced MRI, their structural parameters (particularly wall thickness...
Background . Data from real-life clinical practice studies provide additional information on the efficacy of new antitumor therapy regimens, including in patients who meet exclusion criteria for trials. Aim To evaluate Isaomex triplet multiple myeloma real practice. Materials and methods From 2021 to 2024, retrospective study included 83 double refractory 26 centers aged 38 85 years (median 63), received triplet. Glomerular filtration rate ˂ 60 mL/min was detected at time isatuximabbased...
Aim. To analyze the effectiveness of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a related HLA-identical donor in patients with multiple myeloma (MM). Materials and methods. From 2013 to 2018, study included 8 (6 men, 2 women) aged 27 55 years (median 39 years) MM who underwent allo-HSCT (7 after auto-HSCT, 1 case without previous auto-transplantation). All required or more lines induction therapy, while achieved antitumor effect was unstable. Before allo-HSCT,...
The frequency of achieving complete remission, as well overall and disease-free survival, in multiple myeloma (MM) had increased due to introduction MM treatment regimens high-dose chemotherapy with following autologous hematopoietic stem cell transplantation (ASCT). However the number relapses remains high, caused by persistence residual tumor cells, i.e., presence minimal disease (MRD). One methods for MRD study is multicolor flow cytometry (MFC) where abnormal expression surface antigens...
Introduction . Cytogenetic and genomic traits of tumour cells are considered the key mediating factors in multiple myeloma (MM). Selected chromosomal abnormalities prognostic therapeutic response patient survival MM. Aim — to assess diversity rate MM patients their association with disease course. Materials methods The study enrolled 134 pre-treatment bone marrow FISH assay screening for abnormalities: t(11;14), t(4;14), t(14;16), t(14;20), t(6;14), hyperdiploidy, del13q14/-13,...
Background . The study of influence residual tumor mass, determined by magnetic resonance imaging (MRI), on the progression-free survival (PFS) remains an actual problem. Since visual assessment bone marrow lesion can be one criteria for subsequent personalized treatment choice in multiple myeloma patients. objective was to determine effect lesions detected MRI after autologous hematopoietic stem cells transplantation (auto-HSCT) PFS Materials and methods prospective included 60 patients who...
Introduction . Whole-body diffusion-weighted magnetic resonance imaging (MRI) is an informative method for bone marrow infiltration diagnosis in patients with multiple myeloma (MM) and post-monitoring autologous haematopoietic stem cell transplantation (auto-HSCT). Aim : to study lesions MM using whole-body MRI prior after chemotherapy subsequent auto-HSCT. Materials methods Forty were included a prospective of before high-dose All had at +100 day Antitumour response was assessed induction...
Aim. To study the efficacy and adverse event spectrum of high-dose chemotherapy with subsequent autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients acute renal impairment, including hemodialysis (HD) dependence. Materials & Methods. The retrospective single-center enrolled 64 MM (30 men 34 women) aged 19-65 years (median 54 years), who received auto-HSCT period from 2013 to 2019. Newly diagnosed had a median creatinine 462 nmol/L glomerular...
Background. Multiple myeloma (MM) is a hematological malignancy with plasma cells as substrate. Sometimes MM characterized by plasmacytomas, i.e., intra- and extraosse-ous tumors. A paraffin block containing plasmacytoma substrate provides valuable material to be used for analyzing the molecular biological characteristics of tumor. STR-profil-ing method simultaneous evaluation DNA degradation integral assessment tumor genome stability. Aim. To describe STR-profiles isolated from archival...