A5009202027- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Atherosclerosis and Cardiovascular Diseases
- Healthcare Systems and Public Health
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer Mechanisms and Therapy
- Cardiovascular Disease and Adiposity
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Research on Leishmaniasis Studies
- Lung Cancer Treatments and Mutations
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Occupational Health and Performance
- Acute Lymphoblastic Leukemia research
- Healthcare and Venom Research
- Eicosanoids and Hypertension Pharmacology
Novosibirsk State Medical University
2017-2024
Ministry of Health of the Russian Federation
2020-2024
City Clinical Hospital No. 2
2023
Academy of Sciences of the Republic of Sakha
2023
Aim. To analyze major epidemiological parameters of multiple myeloma, i.e. registered incidence, prevalence, mortality, and survival in Novosibirsk, megalopolis Siberian Federal District. Materials & Methods. The study covered medical records 335 patients with newly diagnosed myeloma (MM) treated from January 1, 2006 to December 31, 2016 at the Center Hematology Novosibirsk. Median age was 67 years (range 30-89), trial enrolled 218 (65 %) women 117 (35 men. Results. Over last decade mean...
Introduction. Chronic lymphocytic leukemia (CLL) is a disease characterized by large individual differences both in the clinical course and molecular patterns of expression genes regulatory RNAs, which can influence pathological changes. The involvement microRNAs miR-155 miR-223 pathogenesis CLL fairly well known, but there insufficient information about possible fluctuations depending on time pathology development parameters medical treatment. Purpose – to investigate patients having with...
Resistance to tyrosine kinase inhibitors (TKIs) is currently an important clinical problem in the management of patients with chronic myeloid leukemia (CML). Recent studies suggested that aberrant cytokine secretion may be among BCR/ABL-independent mechanisms resistance, thus contributing persistence leukemic stem cells spite continuous targeted therapy. The aim study was evaluate concentration cytokines serum CML depending on efficiency Quantitative determination (TNFα, IL-1β, IL-2, IL-4,...
Objectives: The aim of our study was to reveal significant factors, associated with carotid atherosclerotic plaque, using regression analyze. Patients and methods: groups comprised 212 rheumatoid arthritis inpatients at the rheumatology department. General examination, ultrasonography, genotyping by restriction fragment length polymorphism analysis polymerase chain reaction-amplified fragments general examination were performed for all patients. Descriptive statistics, Data are presented as...
Introduction. Cardiovascular complications are more often observed in patients with rheumatoid arthritis. Available cardiovascular risk scales were developed for general population and provide sufficiently adequate assessment of the event likelihood. Studying factors arthritis is necessary timely diagnosis prevention. Objective : To analyze incidence atherosclerotic lesions brachiocephalic arteries associations this pathology factors. Material Methods . Two hundred twelve Caucasian (age 58.0...
Aim. To study incidence and structure of comorbidity in multiple myeloma (MM) patients depending on their age; to determine its effect overall survival, efficacy, safety the first-line therapy real clinical practice. Materials & Methods. Overall, 369 with newly diagnosed MM were enrolled trial from January 2012 December 2017. Among them there 134 men 235 women hospitalized at Unit Hematology Novosibirsk Municipal Clinical Hospital No. 2. Median age was 67 years (range 32-82 years)....
We have analyzed the therapy outcomes of chronic myeloid leukemia patients, received imatinib treatment for more than 12 month (136 patients). Complete hematologic response (CHR) is attained in 88,2 % cases (120 patients), complete cytogenetic (CCR) (ph+
The problem of high mortality in patients with rheumatoid arthritis, one the most common autoimmune diseases, is still unsolved. Many studies have shown a significant impact on cardiovascular risk both traditional and non-traditional factors (genetic, RA-associated etc). To improve individual prognosis, team actions by physicians different specialties are necessary basis good awareness ’ compliance. aim review was to characterize main involved formation give notion about features its...
Introduction. Cardiovascular complications are more often observed in patients with rheumatoid arthritis. Available cardiovascular risk scales were developed for general population and provide sufficiently adequate assessment of the event likelihood. Studying factors arthritis is necessary timely diagnosis prevention. Objective : To analyze incidence atherosclerotic lesions brachiocephalic arteries associations this pathology factors. Material Methods . Two hundred twelve Caucasian (age 58.0...
Relevance . In accordance with the guidelines on clinical investigation of clotting factor VIII products European Medicines Agency and pharmacovigilance Eurasian Economic Union, after registration a new drug, it is recommended to study its efficacy safety large population patients in standard medical practice clarify identify data. Materials methods prospective, multicenter, open-label, uncontrolled observational study, domestic recombinant B-domain deleted blood FVIII (FVIII) (moroctocog...
Background. An increase in the number of patients with multiple myeloma (MM) necessitates creation reliable tools for assessing their somatic status (comorbidity) order to personalize optimal treatment regimen that helps minimize its toxicity, improves survival and quality life. The objective this study was modify MM comorbidity index (MCI) by adding an additional variable reflecting biological properties tumor, determine informativeness new scale – a modified (M-MCI), predict outcome select...
Aim. To assess the associations between predisposition genes (TGF-p1, HHIP, IL6R, SOD3, and CHRNA3), in relation to peripheral vascular structure function, endothelial dysfunction, cytokine status, geriatric patients with chronic obstructive pulmonary disease (COPD) arterial hypertension (AH). Material methods. In total, 154 either isolated AH or combination of COPD underwent clinical, functional, laboratory, ultrasound, cytogenetic examination. Results. The key genes, were identified who...
Aim. To assess cardiac and vascular structure function, blood flow parameters, endothelial dysfunction, cytokine status in patients with arterial hypertension (Ah) chronic obstructive pulmonary disease (COPD), who were administered combination Co-renitec therapy. Material methods.The study included 37 Ah COPD, underwent laboratory, functional, ultrasound examination. Results.During the 6-month therapy, parameters of clinical status, circadian pressure profile, endothelial, vascular, function...
Introduction. Over the past decade significant progress has been made in treatment of patients with chronic myeloid leukemia (CML). In most it is possible to reach a major molecular response (MMR) and maximize overall survival (OS). However, real clinical practice regions Russia, there number unresolved problems that have led deterioration results therapy such as, low patient compliance lack proper control by doctors polyclinics over intake medications course disease. Aim — compare incidence...
Introduction. Despite significant advances in therapy of patients with chronic myeloid leukemia (CML), improved survival rates, development resistance to tyrosine kinase inhibitors (TKIs) remains an urgent problem. Aim. To study the correlation between level expression regulatory proteins p53, c-myc, ki-67 and caspase-3 on bone marrow cells concentration certain pro- anti-inflammatory cytokines blood serum effectiveness CML. Materials methods. Seventy-four CML phase disease receiving TKI...
Introduction. Hypoproductive thrombocytopenias caused by insufficient platelet formation in the bone marrow are usually a manifestation of underlying process characterized inhibition thrombocytopoiesis. They accompany aplastic anemia, acute leukemia, primary myelofibrosis, myelodysplastic syndrome, may be result tumor metastasis to marrow, with substitution megakaryocyte lineage, as well complication radiation therapy and chemotherapy. Aim. To analyze features provision transfusion support...