A5072157660- Cellular transport and secretion
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
- Bacterial Genetics and Biotechnology
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
Hospital for Sick Children
2018-2022
University of Toronto
2021-2022
Institute of Medical Sciences
2021
Phosphoinositides are pivotal regulators of vesicular traffic and signaling during phagocytosis. Phagosome formation, the initial step process, is characterized by local membrane remodeling reorganization actin cytoskeleton that leads to formation pseudopods drive particle engulfment. Using genetically encoded fluorescent probes, we found upon engagement a localized pool PtdIns(3,4)P2 generated sequential activities class I phosphoinositide 3-kinases 5-phosphatases. Depletion this locally...
Abstract Phosphoinositides are pivotal regulators of vesicular traffic and signaling during phagocytosis. Phagosome formation, the initial step process, is characterized by local membrane remodelling reorganization actin cytoskeleton that leads to formation pseudopods drive particle engulfment. Using genetically-encoded fluorescent probes we found upon engagement a localized pool PtdIns(3,4)P 2 generated sequential activities class I phosphoinositide 3-kinases 5-phosphatases. Depletion...
Abstract Despite their comparatively low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P3 PtdIns(3,4)P2 are uniquely important, as they promote cell growth, survival, migration. Pathogenic organisms have developed means to subvert phosphoinositide metabolism successful infection survival within host organisms. We demonstrate that is generated cells by effectors of the enteropathogenic bacteria Salmonella Shigella. Pharmacological, gene...
Abstract Despite their comparatively low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P 3 PtdIns(3,4)P 2 are uniquely important, as they promote cell growth, survival, migration. Pathogenic organisms have developed means to subvert phosphoinositide metabolism successful infection survival within host organisms. We demonstrate that is generated cells by effectors of the enteropathogenic bacteria Salmonella Shigella . Pharmacological, gene...