A5055325854- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Acute Ischemic Stroke Management
- Advanced biosensing and bioanalysis techniques
- Allergic Rhinitis and Sensitization
- Blood groups and transfusion
- Chromosomal and Genetic Variations
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
- DNA and Nucleic Acid Chemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Intracerebral and Subarachnoid Hemorrhage Research
Université de Limoges
2016-2023
Contrôle de la Réponse Immune B et Lymphoproliférations
2016-2023
Montreal Clinical Research Institute
2023
American University of Beirut
2022
Centre National de la Recherche Scientifique
2016-2021
Inserm
2018-2021
B-cell activation yields abundant cell death in parallel to clonal amplification and remodeling of immunoglobulin (Ig) genes by activation-induced deaminase (AID). AID promotes affinity maturation Ig variable regions class switch recombination (CSR) mature B lymphocytes. In the IgH locus, these processes are under control 3’ regulatory region (3’RR) super-enhancer, a demonstrated mouse be both transcribed itself targeted AID-mediated recombination. Alternatively CSR, deletions joining Sμ...
Abstract B cells ensure humoral immune responses due to the production of Ag-specific memory and Ab-secreting plasma cells. In secondary lymphoid organs, Ag-driven cell activation induces terminal maturation Ig isotype class switch (class recombination [CSR]). CSR creates a virtually unique IgH locus in every clone by intrachromosomal between two (S) regions upstream each C region gene. Amount structural features junctions reveal valuable information about mechanism, analysis is useful basic...
Introduction In mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the heavy chain ( IgH ) locus under control its 3’ cis -regulatory region 3’RR ). The is itself transcribed can undergo “locus suicide recombination” (LSR), then deleting constant gene cluster terminating expression. relative contribution LSR to cell negative selection remains be determined. Methods Here, we set up a knock-in mouse reporter model for...
Activation-induced deaminase (AID) is the major actor of immunoglobulin (Ig) gene diversification in germinal center B-cells. From its first description, it was considered as mandatory for class switch recombination (CSR), and this discovery initiated a long quest all AID-interacting factors controlling activity. The mechanisms focusing AID-mediated DNA lesions to given target sequences remain incompletely understood with regards detailed characterization optimal substrates which cytidine...
Abstract B-cell activation yields abundant cell death in parallel to clonal amplification and remodeling of immunoglobulin (Ig) genes by activation-induced deaminase (AID). AID promotes affinity maturation Ig variable regions class switch recombination (CSR) mature B lymphocytes. In the IgH locus, these processes are under control 3’ regulatory region (3’RR) super-enhancer, a demonstrated mouse be both transcribed itself targeted AID-mediated recombination. Alternatively CSR, deletions...
Inhibitors of bromodomain and extra terminal domain (BET) proteins are a new growing class anti-cancer drugs, which decrease oncogene expression by targeting superenhancers. Antibody production is another physiological process relying on superenhancers, it remains to be clarified whether potential immunomodulatory properties BET inhibitors might impact humoral immunity allergy.We thus evaluated immune responses their Th2 context in vitro vivo mice following treatment with the classical...