A5090821896- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Autoimmune Bullous Skin Diseases
Contrôle de la Réponse Immune B et Lymphoproliférations
2023
Université de Limoges
2021-2023
Inserm
2021-2022
Centre National de la Recherche Scientifique
2021
Introduction In mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the heavy chain ( IgH ) locus under control its 3’ cis -regulatory region 3’RR ). The is itself transcribed can undergo “locus suicide recombination” (LSR), then deleting constant gene cluster terminating expression. relative contribution LSR to cell negative selection remains be determined. Methods Here, we set up a knock-in mouse reporter model for...
Upregulated expression of the anti-apoptotic BCL2 oncogene is a common feature various types B-cell malignancies, from lymphoma to leukemia or myeloma. It currently unclear how patterns deregulation observed in pathology eventually impact phenotype malignant B cells and their microenvironment. Follicular (FL) most non-Hodgkin arising germinal center (GC) B-cells, its major hallmark t(14:18) translocation occurring cell progenitors placing gene under control immunoglobulin heavy chain locus...
Abstract Follicular lymphoma (FL) is the most common indolent form of non-Hodgkin arising from malignant germinal center (GC) B-cells. The genetic hallmark that leads to development FL t(14:18) which occurs early in bone marrow during B cell development, thereby placing anti-apoptotic BCL2 gene under direct control transcriptional enhancers 3’ immunoglobulin heavy chain locus (IgH 3’RR) and leading constitutive expression protein. To assess impact deregulation on B-cell fate try reproduce...