A5046600961- Ion channel regulation and function
- RNA regulation and disease
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Redox biology and oxidative stress
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Istanbul University-Cerrahpaşa
2019-2024
Istanbul University
2023
Background and objectives: Ischemia-reperfusion (IR) caused by infrarenal abdominal aorta cross-clamping is an important factor in the development of ischemia-reperfusion injury various distant organs. Materials Methods: We investigated potential antioxidant/anti-inflammatory effects thymosin beta 4 (Tβ4) a rat model aortic surgery-induced IR. Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods. One group...
Chronic intermittent hypoxia (CIH), a component of sleep apnea-hypopnea syndrome, is suggested to cause damage lung tissue, and the role glutamate not well studied. We used chronic long-term hypobaric (CLTIHH) model rats find out if such procedure causes injury potential effect N-methyl-D-aspartate receptors (NMDARs) by using receptor antagonist MK-801 (dizocilpine). Thirty-two were placed into four groups; control three CLTIHH groups where low-pressure chamber set 430 mmHg for 5 h/day,...
Abstract Metformin has been suggested to have protective effects on the central nervous system with an unclarified mechanism. The similarity between of metformin and inhibition glycogen synthase kinase (GSK)-3β suggests that may inhibit GSK-3β. In addition, zinc is important element inhibits GSK-3β by phosphorylation. this study, it was investigated whether neuroprotection neuronal survival were mediated zinc-dependent in rats glutamate-induced neurotoxicity. Forty adult male divided into 5...