A5066549661- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Ion Channels and Receptors
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Neuroscience of respiration and sleep
- Urban and sociocultural dynamics
- Morinda citrifolia extract uses
- Anesthesia and Pain Management
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Ion Transport and Channel Regulation
- Myofascial pain diagnosis and treatment
- Urban Development and Societal Issues
- Magnolia and Illicium research
- Migraine and Headache Studies
- Multiple Sclerosis Research Studies
- Olfactory and Sensory Function Studies
- Pain Management and Opioid Use
- Hormonal and reproductive studies
- Biofuel production and bioconversion
- Nitric Oxide and Endothelin Effects
- Sugarcane Cultivation and Processing
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade Federal de Santa Catarina
2020-2025
New York University
2025
Alberta Children's Hospital
2024
University of Calgary
2024
Secretaria de Agricultura e Abastecimento
2023
Chronic pruritus is a major unmet clinical problem affecting one in four adults. G protein-coupled receptors (GPCRs) are key driving itch signaling and therapeutic target for relief. The endosomal of GPCRs provides new challenges understanding how GPCR regulated, contributes to disease states like chronic opens targets development. Gastrin releasing peptide receptor (GRPR) mediator the spinal cord. Yet, little known about molecular mechanisms regulating GRPR pruritus, if can signal from...
Migraine represents one of the major causes disability worldwide and is more prevalent in women; it also related to anxiety symptoms. Stress, such as sound stress, a frequently reported trigger migraine patients, but underlying mechanisms are not fully understood. However, known that patients with have higher levels plasma inflammatory cytokines calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable already used model painful sensitization, migraine-like behaviors sexual...
Central neuropathic pain is the main symptom caused by spinal cord lesion in relapsing-remitting multiple sclerosis (RRMS), but its management still not effective. The transient receptor potential ankyrin 1 (TRPA1) a detecting ion channel involved development. Thus, aim of our study was to evaluate role TRPA1 central nociception induced experimental autoimmune encephalomyelitis (RR-EAE) mouse model. In this model, we observed development similar clinical conditions RRMS C57BL/6 female mice...
More than 80% of patients may experience acute pain after a surgical procedure, and this is often refractory to pharmacological intervention. The identification new targets treat postoperative necessary. There an association polymorphisms in the Ca
Abstract Renal vascular reactivity to vasoconstrictors is preserved in sepsis opposition what happens the systemic circulation. We studied whether this distinct behavior was related α1 adrenergic receptor density, G protein-coupled kinase 2 (GRK2) and putative role of nitric oxide (NO). Sepsis induced female mice by cecal ligation puncture (CLP). Wildtype were treated with prazosin 12 h after CLP or synthase (NOS-2) inhibitor, 30 min before 6 CLP. In vivo experiments biochemistry assays...
Background and purpose Migraine represents one of the major causes disability worldwide is more prevalent in women, it also related to anxiety symptoms. Stress a frequently reported trigger migraine patients, such as sound stress, but underlying mechanisms are not fully understood. However, known that patients with have higher levels plasma inflammatory cytokines calcitonin gene-related peptide (CGRP). mediated by unpredictable already used model painful sensitization, migraine-like...