A5048022663- Cancer, Stress, Anesthesia, and Immune Response
- Nerve injury and regeneration
- Advanced Proteomics Techniques and Applications
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Axon Guidance and Neuronal Signaling
- Proteoglycans and glycosaminoglycans research
- 14-3-3 protein interactions
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Biotin and Related Studies
- Thyroid Cancer Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
University of Newcastle Australia
2015-2024
Hunter Medical Research Institute
2015-2024
Federation of American Societies for Experimental Biology
2023
University of Michigan
2023
Hunter Cancer Research Alliance
2015-2021
University of Washington
2016
Institut de Biologie de Lille
2016
Institute of Biomedical Science
2015
Bio-Medical Science (South Korea)
2015
Université de Lille
1996-2011
The imprinted H19 gene has riboregulatory functions. We show here that transcription is up-regulated during the S-phase of growth-stimulated cells and promoter activated by E2F1 in breast cancer cells. repression pRb E2F6 confirms E2F1-dependent control promoter. Consistently, we demonstrate chromatin immunoprecipitation assays endogenous recruited to vivo. functionality E2F sites was further confirmed gel shift mutagenesis experiments, revealing these are required for binding response...
Summary: The field of cancer neuroscience has begun to define the contributions nerves initiation and progression; here, we highlight future directions basic translational for malignancies arising outside central nervous system.
We show here that the neurotrophin nerve growth factor (NGF), which has been shown to be a mitogen for breast cancer cells, also stimulates cell survival through distinct signaling pathway. Breast lines (MCF-7, T47-D, BT-20, and MDA-MB-231) were found express both types of NGF receptors: p140(trkA) p75(NTR). The two other tyrosine kinase receptors neurotrophins, TrkB TrkC, not expressed. mitogenic effect on cells required activity as well mitogen-activated protein (MAPK) cascade, but was...
Abstract We show here that nerve growth factor (NGF), the prototypic neurotrophin, can be targeted in breast cancer to inhibit tumor cell proliferation, survival, and metastasis. Analysis of a series biopsies revealed widespread expression NGF majority human tumors, with anti-NGF immunoreactivity concentrated epithelial cells. Moreover, immunodeficient mice xenografted cells treated either antibodies or small interfering RNA against displayed inhibited Such treatments directed induced...
The H19/IGFf2 locus belongs to a large imprinted domain located on human chromosome 11p15.5 (homologue mouse distal 7). H19 gene is expressed from the maternal allele, while IGF2 paternally expressed. Natural antisense transcripts and intergenic transcription have been involved in many aspects of eukaryotic expression, including genomic imprinting RNA interference. However, apart identification some transcripts, few data are available that topic at H19/IGF2 locus. We identify here novel...
Heterogeneity and lack of targeted therapies represent the two main impediments to precision treatment triple-negative breast cancer (TNBC), therefore, molecular subtyping identification therapeutic pathways are required optimize medical care. The aim present study was define robust TNBC subtypes with clinical relevance. Gene expression profiling by means DNA chips conducted in an internal cohort composed 238 patients. In addition, external data (n = 257), obtained using same chip, were used...
Abstract Background Although several anti-angiogenic therapies have been approved in the treatment of cancer, survival benefits such are relatively modest. Discovering new molecules and/or better understating signaling pathways angiogenesis is therefore essential for therapeutic improvements. The objective present study was to determine involvement nerve growth factor (NGF) breast cancer and underlying molecular mechanisms. Results We showed that both recombinant NGF produced by cells...
Given that nerve growth factor has previously been shown to be involved in breast cancer progression, we have tested here the hypothesis other neurotrophins (NT) are expressed and an influence tumor growth.The expression of brain-derived neurotrophic (BDNF), NT-3 NT-4/5, as well neurotrophin receptor p75(NTR), TrkB, TrkC, was studied by RT-PCR, Western blotting, immunohistochemistry cell lines biopsies. The biological impacts neurotrophins, associated mechanisms, were analyzed cultures...
// Séverine Roselli 1, 2 , Jay Pundavela Yohann Demont 3, 5 Sam Faulkner Sheridan Keene John Attia 2, 4 Chen Jiang Xu Dong Zhang Marjorie M. Walker Hubert Hondermarck 1 School of Biomedical Sciences & Pharmacy, Faculty Health and Medicine, University Newcastle, Callaghan NSW 2308, Australia Hunter Medical Research Institute, New Lambton 2305, 3 INSERM U908, IFR-147, Universite Lille Villeneuve d'Ascq 59655, France Public U1138, Equipe 11, Centre de Recherche des Cordeliers, Paris 75006,...