About
Contact & Profiles
A5054694754
Research Areas
- RNA Interference and Gene Delivery
- T-cell and Retrovirus Studies
- Histone Deacetylase Inhibitors Research
- Vector-Borne Animal Diseases
Friedrich-Alexander-Universität Erlangen-Nürnberg
2021-2022
Universitätsklinikum Erlangen
2022
The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as latency-reversing agent to boost expression expose infected cells host's immune response. However, following treatment with proviral load decreases patients HAM/TSP were only transient. Here, we hypothesize that other compounds, including more potent selective HDACi, might prove superior manipulating expression....
10.3389/fimmu.2022.978800
article
EN
cc-by
Frontiers in Immunology
2022-08-16
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