A5013842270- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
- Animal Disease Management and Epidemiology
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Histone Deacetylase Inhibitors Research
- Parasite Biology and Host Interactions
- Maritime and Coastal Archaeology
- Forensic and Genetic Research
- Archaeology and Historical Studies
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Archaeology and ancient environmental studies
Imperial College London
2019-2024
Ludwig-Maximilians-Universität München
2022
Abstract Signaling from ciliary microdomains controls developmental processes in metazoans. Trypanosome transmission requires development and migration the tsetse vector alimentary tract. Flagellar cAMP signaling has been linked to parasite social motility (SoMo) vitro, yet uncovering control of directed fly organs is challenging. Here we show that composition an adenylate cyclase (AC) complex flagellar tip microdomain essential for salivary gland (SG) colonization SoMo. Cyclic AMP response...
Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus with preferential CD4+ tropism that causes range of conditions spanning from asymptomatic infection to adult and HTLV-1-associated myelopathy (HAM), an inflammatory disease the CNS. The mechanisms by which HTLV-1 induces HAM are poorly understood. By directly examining ex vivo phenotype function cells carriers patients HAM, we show have higher frequency CD4+CD8+ double-positive (DP) cells, infected at rates than cells. Displaying...
The viral transactivator Tax plays a key role in HTLV-1 reactivation and de novo infection. Previous approaches focused on the histone deacetylase inhibitor (HDACi) Valproate as latency-reversing agent to boost expression expose infected cells host's immune response. However, following treatment with proviral load decreases patients HAM/TSP were only transient. Here, we hypothesize that other compounds, including more potent selective HDACi, might prove superior manipulating expression....
Monoallelic exclusion ensures that the African trypanosome Trypanosoma brucei exclusively expresses only 1 of thousands different variant surface glycoprotein (VSG) coat genes. The active VSG is transcribed from 15 polycistronic bloodstream-form expression sites (ESs), which are controlled in a mutually exclusive fashion. Unusually, T. uses RNA polymerase I (Pol I) to transcribe ES, unprecedented among eukaryotes. This ES located within unique extranucleolar Pol body called expression-site...
Archaeological evidence supports sporadic seafaring visits to the Eastern Mediterranean island of Cyprus by Epipaleolithic hunter-gatherers over 12,000 years ago, followed permanent settlements during early Neolithic. The geographical origins these seafarers have so far remained elusive. By systematically analysing all available genomes from late Pleistocene Holocene Near East (c. 14,000-7000 cal BCE), we provide a comprehensive overview genetic landscape Neolithic Fertile Crescent and...
Infections by Human T cell Leukaemia Virus type 1 (HTLV-1) persist for the lifetime of host integrating into genome CD4+ cells. Proviral gene expression is essential proviral survival and maintenance load, through pro-proliferative changes it induces in infected Despite their role HTLV-1 infection a persistent cytotoxic lymphocyte response raised against virus, transcripts from sense-strand are rarely detected fresh cells extracted peripheral blood, have recently been found to be expressed...
Abstract Signaling from ciliary nanodomains controls developmental processes in metazoans. Trypanosome transmission requires development and migration the tsetse vector alimentary tract. Flagellar cAMP signaling has been linked to parasite social motility (SoMo) vitro, yet uncovering control of directed fly organs is challenging. Here we show that architecture an adenylate cyclase (AC) complex flagellar tip nanodomain essential for salivary gland (SG) colonization SoMo. Cyclic AMP response...
Abstract Infections by Human T cell Leukaemia Virus type 1 (HTLV-1) persist for the lifetime of host integrating into genome CD4 + cells. Proviral gene expression is core to proviral survival and maintenance load, through pro-proliferative changes it induces in infected Despite their role HTLV-1 infection a persistent cytotoxic lymphocyte response raised against them, transcripts from sense-strand are rarely detected fresh cells extracted peripheral blood, have recently been found be...
Abstract The origins of the Albanian people have vexed linguists and historians for centuries, as Albanians first appear in historical record 11 th century CE, while their language is one most enigmatic branches Indo-European family. To identify populations that contributed to ancestry Albanians, we undertake a genomic transect Balkans over last 8000 years, where analyse more than 6000 previously published ancient genomes using state-of-the-art bioinformatics tools algorithms quantify...