A5013810317- Long-Term Effects of COVID-19
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- T-cell and Retrovirus Studies
- Sphingolipid Metabolism and Signaling
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Inflammasome and immune disorders
- Immune cells in cancer
Imperial College London
2022-2024
Faculty (United Kingdom)
2024
Abstract Although alterations in myeloid cells have been observed COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine function of classical CD14 + monocytes patients with mild and moderate COVID-19 during acute phase infection healthy individuals. Monocytes from display altered expression cell surface receptors a dysfunctional metabolic profile that distinguish them monocytes. Secondary pathogen sensing ex vivo leads to defects pro-inflammatory...
Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus with preferential CD4+ tropism that causes range of conditions spanning from asymptomatic infection to adult and HTLV-1-associated myelopathy (HAM), an inflammatory disease the CNS. The mechanisms by which HTLV-1 induces HAM are poorly understood. By directly examining ex vivo phenotype function cells carriers patients HAM, we show have higher frequency CD4+CD8+ double-positive (DP) cells, infected at rates than cells. Displaying...
With an estimated 10 million people infected, the deltaretrovirus human T-cell lymphotropic virus type 1 (HTLV-1) is second most prevalent pathogenic retrovirus in humans after HIV-1. Like HIV-1, HTLV-1 overwhelmingly persists a host via reservoir of latently infected CD4+ T cells. Although patients are asymptomatic, HTLV-1-associated pathologies often debilitating and include adult leukaemia/lymphoma (ATLL), which presents mature adulthood associated with poor prognosis short overall...
Abstract Alterations in the myeloid immune compartment have been observed COVID-19, but specific mechanisms underlying these impairments are not completely understood. Here we examined functionality of classical CD14 + monocytes as a main cell component well-defined cohorts patients with mild and moderate COVID-19 during acute phase infection compared them to that healthy individuals. We found ex vivo isolated from display patterns costimulatory inhibitory receptors clearly distinguish...
Abstract Inflammatory environments induce the generation of dysfunctional IFN γ + T-bet FOXP3 Th1-like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control Tregs not well understood. Sphingosine-1-phosphate (S1P) signaling molecules upregulated vivo S1P inhibition with Fingolimod (FTY720) inhibits expression genes responsible for Treg plasticity MS patients. However, underlying mechanisms unknown. Here we by...
ABSTRACT Inflammatory environments induce the generation of dysfunctional IFNγ + T‐bet FOXP3 Th1‐like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control Tregs not well understood. Sphingosine‐1‐phosphate (S1P) signalling molecules upregulated vivo S1P inhibition with Fingolimod (FTY720) inhibits expression genes responsible for Treg plasticity MS patients. However, underlying mechanisms unknown. Here we by...