A5103188379- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Genetic Neurodegenerative Diseases
- Myasthenia Gravis and Thymoma
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Sphingolipid Metabolism and Signaling
- Infectious Encephalopathies and Encephalitis
- Organ Transplantation Techniques and Outcomes
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Family and Patient Care in Intensive Care Units
- Neuroinflammation and Neurodegeneration Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Kawasaki Disease and Coronary Complications
- Alzheimer's disease research and treatments
- Pathogenesis and Treatment of Hiccups
- Neurological and metabolic disorders
Charing Cross Hospital
2023-2025
Imperial College Healthcare NHS Trust
2020-2025
University College London
2015-2024
University of Oxford
2015-2024
John Radcliffe Hospital
2014-2024
St Mary's Hospital
2024
St. Mary's Hospital
2024
Imperial College London
2014-2023
Cambridge University Hospitals NHS Foundation Trust
2023
John Wiley & Sons (United States)
2021
<h3>Objective</h3> To describe a novel case of coronavirus disease 2019 (COVID-19)-associated acute necrotizing encephalopathy (ANE) in patient with aplastic anemia where there was early brain stem-predominant involvement. <h3>Methods</h3> Evaluation cause, clinical symptoms, and treatment response. <h3>Results</h3> A 59-year-old woman background transfusion-dependent presented seizures reduced level consciousness 10 days after the onset subjective fever, cough, headache. Nasopharyngeal swab...
The recent biochemical distinction between antibodies against leucine-rich, glioma-inactivated-1 (LGI1), contactin-associated protein-2 (CASPR2) and intracellular epitopes of voltage-gated potassium-channels (VGKCs) demands aetiological explanations. Given established associations human leucocyte antigen (HLA) alleles adverse drug reactions, our clinical observation frequent drugs reactions in patients with LGI1 antibodies, we compared HLA healthy controls (n = 5553) 111 Caucasian...
Introduction N‐methyl‐D‐aspartate receptor (NMDAR) antibody encephalitis is mediated by immunoglobulin G (IgG) autoantibodies directed against the NR1 subunit of NMDAR. Around 20% patients have an underlying ovarian teratoma, and condition responds to early immunotherapies teratoma removal. However, despite clear therapeutic relevance, mechanisms NR1‐IgG production contribution germinal center B cells levels are unknown. Methods Clinical data longitudinal paired serum NR1‐reactive IgM IgG...
Autoantibodies to aquaporin-4 (AQP4) are pathogenic in neuromyelitis optica spectrum disorder (NMOSD). However, it is not known which B cells the major contributors circulating AQP4 antibodies nor conditions promote their generation. Our experiments showed CD19+CD27++CD38++ ex vivo antibody-secreting did produce under several culture conditions. To question whether other circulation were capable of antibody production, differentiated into vitro. Unfractionated peripheral blood mononuclear...
Pain is a under-recognized association of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 33 (52%) CASPR2- versus 20 108 (19%) LGI1 antibodies (p = 0.0005), identified as neuropathic in 89% 58% these, respectively. Typically, both cohorts, normal nerve conduction studies reduced intraepidermal fiber densities were observed the sampled patient subsets. In antibody...
In 2015, we wrote a review in The Journal of Neurology summarizing the field autoantibody-associated neurological diseases. Now, 2023, present an update subject which reflects rapid expansion and refinement associated clinical phenotypes, further autoantibody discoveries, more detailed understanding immunological neurobiological pathophysiological pathways mediate these Increasing awareness around distinctive aspects their phenotypes has been key driver providing clinicians with better as to...
To test the performance of 2023 myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) criteria in adults and children with inflammatory demyelinating conditions who were tested for MOG antibodies (Abs).
Autoimmune encephalitis can be classified into antibody-defined subtypes, which manifest with immunotherapy-responsive movement disorders sometimes mimicking non-inflammatory aetiologies. In the elderly, anti-LGI1 and contactin associated protein like 2 (CASPR2) antibody-associated diseases compose a relevant fraction of autoimmune encephalitis. Patients LGI1 autoantibodies are known to present limbic additionally faciobrachial dystonic seizures may occur. However, clinical spectrum CASPR2...
Despite it being an immunotherapy-responsive neurological syndrome, patients with autoimmune encephalitis (AE) frequently exhibit residual neurobehavioural features. Here, we report criminal behaviours as a serious and novel postencephalitic association.
Abstract In this report, we describe a female patient with trisomy 4p, rare genetic condition, unusual seizure semiology. The is one of the oldest reported survivors condition. This semiology was noted while she being monitored by inpatient video telemetry. We observed series myoclonic shoulder jerks, followed hiccup‐like episodes, and finally an atonic head drop. Corresponding ictal EEG showed semi‐rhythmic high‐amplitude slow waves spikes superimposed over frontotemporal areas. confirmed...
Leucine-rich glioma-inactivated 1 (LGI1)-antibody encephalitis is a treatable disease within the ever-expanding group of autoimmune encephalitides. The illness typically characterized by subacute onset amnesia, confusion, and seizures in middle age, with approximately 60% patients showing medial temporal lobe T2 hyperintensities.1,2,e1,e2 most characteristic seizure syndrome associated LGI1 antibody recently termed entity faciobrachial dystonic (FBDS).3–5 FBDS consist brief, frequent...
Abstract Inflammatory environments induce the generation of dysfunctional IFN γ + T-bet FOXP3 Th1-like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control Tregs not well understood. Sphingosine-1-phosphate (S1P) signaling molecules upregulated vivo S1P inhibition with Fingolimod (FTY720) inhibits expression genes responsible for Treg plasticity MS patients. However, underlying mechanisms unknown. Here we by...
ABSTRACT Inflammatory environments induce the generation of dysfunctional IFNγ + T‐bet FOXP3 Th1‐like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control Tregs not well understood. Sphingosine‐1‐phosphate (S1P) signalling molecules upregulated vivo S1P inhibition with Fingolimod (FTY720) inhibits expression genes responsible for Treg plasticity MS patients. However, underlying mechanisms unknown. Here we by...
Neuroinflammation is increasingly recognized as a significant factor in the pathophysiology of many neurodegenerative disorders. Microglial activation, visualized by [11C](R)PK11195 PET scans, has been inversely correlated with cognitive status Parkinson's disease dementia (PDD) and Alzheimer's (AD), recent findings from novel microglial tracers have also reported correlations between neuroinflammation grey matter volume AD. Here we hypothesize that increased activation associated reduced...
<h3>Introduction</h3> Patient survival in dACLD progressing to ACLF has improved but mortality remains high and there is still lack of consistency what best clinical practice (1,2). Our aim was explore regional escalation care this patient group guide further areas for improvement within our East England (EoE) hepatology (Hep) intensive unit (ICU) network. <h3>Methods</h3> A survey sent Consultants EoE region at both secondary tertiary centres. It consisted three vignettes questions (Case 1:...
Immunoglobulin G (IgG) against the NR1-subunit of N-methyl-D-aspartate (NMDAR) receptor mediates NMDAR-antibody encephalitis (NMDAR-Ab-E). This multi-stage illness presents with an acute severe psychiatric syndrome, alongside other neurological features, similar to human and animal NMDAR antagonist models. The disease is associated ovarian teratoma in around 20% cases. cellular immunity underlying this not well understood. While antibody-modifying immunotherapies often promote resolution,...