A5079432286- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- Vitamin C and Antioxidants Research
- Glycosylation and Glycoproteins Research
- Risk and Safety Analysis
- Vascular anomalies and interventions
- Cholesterol and Lipid Metabolism
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Photoreceptor and optogenetics research
- Calpain Protease Function and Regulation
- Connexins and lens biology
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Fire Detection and Safety Systems
- Neurobiology and Insect Physiology Research
- Biochemical effects in animals
- Vestibular and auditory disorders
- melanin and skin pigmentation
- Cell death mechanisms and regulation
- Cellular Mechanics and Interactions
Washington University in St. Louis
2016-2021
Gwangju Institute of Science and Technology
2017
The University of Texas at Austin
2016
Institute for Learning and Development
2013
Hanyang University
1995
Neuroinflammation and necroptosis are major contributors to neurodegenerative disease, axon dysfunction degeneration is often an initiating event. SARM1 the central executioner of pathological degeneration. Here, we demonstrate functional mechanistic links among these three pro-degenerative processes. In a neuroinflammatory model glaucoma, TNF-α induces SARM1-dependent degeneration, oligodendrocyte loss, subsequent retinal ganglion cell death. also triggers in sensory neurons via...
Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by “dying-back” axonopathy that begins at intra-epidermal nerve terminals of sensory neurons progresses in retrograde fashion. Calcium dysregulation constitutes critical event CIPN, but it not known how chemotherapies such as...
Highlights•The neurotoxin 3-acetylpyridine is converted into a SARM1 allosteric activator•The binding site relatively promiscuous•SARM1 candidate mediator of environmental neurotoxicity•SARM1 agonists could be developed selective agents for neurolytic therapySummarySARM1 an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. activated by increased ratio NMN to NAD+, which competes activating site. When binds, the TIR domain released from autoinhibition, its...
SARM1 is an inducible NAD + hydrolase that triggers axon loss and neuronal cell death in the injured diseased nervous system. While activation enzyme function are well defined, cellular events downstream of activity but prior to axonal demise much less understood. Defects calcium, mitochondria, ATP, membrane homeostasis occur axons, relationships among these have been difficult disentangle because studies analyzed large collections axons which asynchronously. Here, we used live imaging mouse...
Presynaptic axonal varicosities, like postsynaptic spines, are dynamically added and eliminated even in mature neuronal circuitry. To study the role of this structural plasticity behavioral learning, we performed two-photon vivo imaging cerebellar parallel fibers (PFs) adult mice. PFs make excitatory synapses on Purkinje cells (PCs) cortex, long-term potentiation depression at PF-PC thought to play crucial roles cerebellar-dependent learning. Time-lapse vital revealed that, under a control...
During brain development, dynamic changes in neuronal membranes perform critical roles morphogenesis and migration to create functional neural circuits. Among the proteins that induce membrane dynamics, cell adhesion molecules are important plasticity. Here, we report V-set transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging Ig superfamily, was found mouse brain. Knock-down of Vstm5 cultured hippocampal neurons markedly reduced complexity dendritic...
SUMMARY SARM1 is an inducible TIR-domain NAD + hydrolase that mediates pathological axon degeneration. activated by increased ratio of NMN to , which competes for binding allosteric activating site. When binds, the TIR domain released from autoinhibition, its activity. The discovery this site led us hypothesize other -related metabolites might also activate SARM1. Here we show nicotinamide analogue 3-acetylpyridine (3-AP), first identified as a neurotoxin in 1940s, converted 3-APMN activates...
SUMMARY Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by “dying-back” axonopathy that begins at intra-epidermal nerve terminals of sensory neurons progresses in retrograde fashion. Calcium dysregulation constitutes critical event CIPN, but it not known how chemotherapies such...
Abstract SARM1 is an inducible NAD + hydrolase that triggers axon loss and neuronal cell death in the injured diseased nervous system. While activation enzyme function are well defined, cellular events downstream of activity but prior to axonal demise much less understood. Defects calcium, mitochondria, ATP, membrane homeostasis occur axons, relationships among these have been difficult disentangle because studies analyzed large collections axons which asynchronously. Here we used live...
V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein, can induce protrusions in various cells. Vstm5 modulate both the position complexity of central neurons by altering their morphology dynamics. In this study, we investigated significance glycosylation expression function Vstm5. Four N-linked sites (Asn43, Asn87, Asn101, Asn108) are predicted to be located extracellular N-terminus mouse Although all four were glycosylated,...
Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by “dying-back” axonopathy that begins at intra-epidermal nerve terminals of sensory neurons progresses in retrograde fashion. Calcium dysregulation constitutes critical event CIPN, but it not known how chemotherapies such as...
In general, crop protection agents are of great interest in research and development to increase productivity by protecting crops from various pests. However, if a safety accident occurs during the manufacturing process agents, serious environmental pollution can occur, several fires accidents related have occurred Korea. it was not effective preventing fire as simply treated spontaneous ignition or carelessness without clear cause. Therefore, through this thesis, probability studied sharing...