A5046163814- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Effects of Radiation Exposure
- Thermoregulation and physiological responses
- Retinal Development and Disorders
- Image Processing Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Concrete and Cement Materials Research
- Advanced Neural Network Applications
- Concrete Corrosion and Durability
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Retinal and Optic Conditions
- Optical Imaging and Spectroscopy Techniques
- Retinal Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Olfactory and Sensory Function Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Nanoplatforms for cancer theranostics
- Medical Image Segmentation Techniques
- Innovative concrete reinforcement materials
University of Iowa
2020-2025
Iowa City VA Health Care System
2019-2025
University of Utah
2017
Retinal image registration is essential for monitoring eye diseases and planning treatments, yet it remains challenging due to large deformations, minimal overlap, varying quality. To address these challenges, we propose RetinaRegNet, a multi-stage model with zero-shot generalizability across multiple retinal imaging modalities. RetinaRegNet begins by extracting features using pretrained latent diffusion model. Feature points are sampled from the fixed combination of SIFT algorithm random...
Background/Objectives: Radiation therapy can often lead to structural and functional changes in the brain resulting radiation-induced injury. This study investigates MRI-detectable effects of whole-brain irradiation across all neuroanatomical structures adult mice, with a specific focus on T2* MRI measurements, evaluate regions that may be particularly sensitive iron accumulation. Methods: One year following or sham treatment, mice were imaged 7T regional volume relaxation times more than...
Patients with choroidal melanoma treated brachytherapy lose vision over time due to radiation retinopathy and optic neuropathy. Newer imaging modalities such as optical coherence tomography angiography (OCT-A) may provide further insight into the ultrastructural vascular changes that occur time. We studied progressive OCT-A derived reduction in capillary density occurred macula juxtapapillary region of a patient plaque for posterior uveal melanoma.
Abstract Background To determine whether reductions in retinal and choroidal blood flow measured by laser speckle flowgraphy are detected after 125 I-plaque brachytherapy for uveal melanoma. Methods In a cross-sectional study, were using 25 patients treatment with Flow was analyzed the peripapillary region mean blur rate as well entire image area novel superpixel-based method. Relationships between measures determined Spearman correlation. Results Significant decreases observed both vascular...
Abstract Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in central macula. A robust retinal layer segmentation is required identification specific layers involved radiation-induced pathology individual eyes over time, order to determine damage driven by injury microvessels inner neurons. Here, we utilized OCT, OCT-angiography, visual field testing, patient-specific dosimetry models analyze...
We introduce the RetinaRegNet model, which can achieve state-of-the-art performance across various retinal image registration tasks. does not require training on any images. It begins by establishing point correspondences between two images using features derived from diffusion models. This process involves selection of feature points moving SIFT algorithm alongside random sampling. For each selected point, a 2D correlation map is computed assessing similarity vector at that and vectors all...
The MR transverse relaxation rate, R2*, has been widely used to detect iron and myelin content in tissue. However, it is also sensitive macroscopic B0 inhomogeneities. One approach correct for the effect fit gradient-echo signals with three-parameter model, a sinc function-weighted monoexponential decay. such models are subject increased noise sensitivity. To address this issue, study presents two-stage fitting procedure based on model mitigate reduce sensitivity of R2* measurement mouse...
Purpose: The purpose of this study was to investigate the applicability laser speckle flowgraphy (LSFG) for a longitudinal blood flow parameters in mice before, during, and after continuous infusion angiotensin-II. Methods: Normotensive C57BL/6J were imaged by LSFG at one (n = 22) or three sessions 10). Two additional cohorts angiotensin-II minipump 2 4 weeks 6 8, respectively). Retinal flow, vascular resistance, total area retinal surrogate remodeling vasoconstriction, determined each time...
Purpose: To define the temporal relationship of vascular versus neuronal abnormalities in radiation retinopathy. Methods: Twenty-five patients with uveal melanoma treated brachytherapy and sixteen controls were tested. Functional outcome measures included visual acuity threshold perimetry (HVF 10-2), while structural outcomes retinal thickness by OCT angiography digital fundus photography. The degree abnormality was determined intereye asymmetry compared normal subject asymmetry. Diagnostic...
Laser speckle flowgraphy (LSFG) is a non-invasive imaging technology for quantifying microvascular blood flow. In the eye, LSFG quantifies relative dynamics of flow retina, choroid and optic nerve head on continuous scale. Currently, analysis requires placement "rubber bands" (defining regions interest) to measure at desired locations. However, rubber bands knowledge which are likely be affected by disease. Here, we demonstrate fully automated superpixel-histogram method without band...
In this paper, we present a summary of preliminary experiments and numerical assessments the effects gamma radiation induced formation free radicals in curing stage concrete on its characteristics. Substantial literature reports damaging long-term high-dose neutron exposure concrete. However, show that short-term to can be beneficial increasing compressive strength. The exposing 630 MBq 137Cs 56 cubes each made 125 cm3 during first seven days are compared another cured by conventional...