A5062141749- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Chronic Disease Management Strategies
- Pharmaceutical studies and practices
- Antibiotic Use and Resistance
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Clinical Nutrition and Gastroenterology
- Antimicrobial Resistance in Staphylococcus
- Frailty in Older Adults
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Statistical Methods in Clinical Trials
- Immunodeficiency and Autoimmune Disorders
- Neonatal and Maternal Infections
- Advanced Breast Cancer Therapies
- Cytomegalovirus and herpesvirus research
- Blood disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- Melanoma and MAPK Pathways
- Veterinary Pharmacology and Anesthesia
- Dermatology and Skin Diseases
- Autoimmune Neurological Disorders and Treatments
Hospital Universitario Virgen del Rocío
2018-2025
Instituto de Biomedicina de Sevilla
2020-2025
Universidad de Sevilla
2022-2025
Centro de Investigación Biomédica en Red
2023
Hospital Son Llatzer
2022
New nucleos(t)ide reverse transcriptase inhibitors are considerably less toxic than their predecessors, but they may not be entirely devoid of toxicity. However, effect in healthy adults remains unknown. We aimed to analyze the impact tenofovir disoproxil fumarate (TDF) plus emtricitabine (FTC)-based preexposure prophylaxis (PrEP) on mitochondria subjects at high risk HIV-1 infection. This is an observational, prospective study 59 enrolled PrEP program Virgen del Rocio University Hospital....
We aimed to define a novel indicator for monitoring antimicrobial use specifically in the Emergency Department Observation Unit (EDOU) and assess long-term impact of an institutional education-based stewardship program (ASP) on prescribing pattern clinical outcomes this setting. A quasi-experimental interrupted time-series study was performed from 2011 2022. An educational ASP implemented at EDOU 2015. To estimate changes use, we designed adjusted patients risk prescribing: defined daily...
Real-life data on doravirine (DOR) in different drug combinations are limited. We evaluated the effectiveness of DOR plus two nucleos(t)ide reverse transcriptase inhibitors (NRTI), mainly abacavir/lamivudine, and dual therapies people with HIV (PWH), mostly virologically suppressed. Ambispective observational study that enrolled adults PWH who initiated a DOR-based regimen from September 2020 to February 2022 at referral center Spain. Participants were grouped as follows: A, received NRTI;...
<h3>Background and Importance</h3> Nirmatrelvir/ritonavir (N/R) is an oral treatment for COVID-19 that reduces the risk of developing severe disease. Renal transplant patients are treated with immunosuppressants such as tacrolimus, metabolised by CYP43A well N/R. Co-administration irreversible CYP3A4 inhibitor ritonavir, associated serious interactions toxicity in patients. <h3>Aim Objectives</h3> To describe management N/R tacrolimus renal <h3>Material Methods</h3> A 49-year-old woman...
Antimicrobial stewardship programs (ASPs) optimize antimicrobial use, improve patient outcomes, and reduce resistance. To assess the effectiveness of ASPs, it is necessary to have indicators that can be widely used. Defined daily dose (DDD) was designed by WHO for adult population as a consumption indicator. However, there are no DDDs adapted pediatric population. The main objective this study establish most appropriate DDD values in An observational, retrospective, multicenter conducted....
Vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets have not been validated in the neonatal population as no specifically designed studies are available. The main goal of this study was to analyze therapeutic vancomycin regimen, 24-h area under curve (AUC24), and trough plasma concentration (Ct) obtained that achieved clinical microbiological effectiveness a cohort neonates. This an observational, prospective, single-center covering period 2 years. Eligible patients were neonates...
Abstract Background and Objectives Potentially inappropriate medication refers to the prescription of drugs whose risks outweigh benefits. There are different pharmacotherapeutic optimization strategies detect avoid potentially medications (PIMs), namely deprescription. The List Evidence-Based Deprescribing for Chronic Patients (LESS-CHRON) criteria were designed as a tool systematize deprescribing process. LESS-CHRON has established itself one most suitable be applied in older (≥65 years)...
<h3>Background</h3> Antimicrobial stewardship programmes (ASPs) optimise antimicrobial use, improve patient outcomes, and reduce resistance. To assess the effectiveness of ASPs, it is necessary to have indicators that can be widely used. Defined daily dose (DDD) was designed by World Health Organization for adult population as a consumption indicator. <h3>Objectives</h3> Validate tool in phase I KiDDDs project establish most appropriate DDD values paediatric population. <h3>Material...
<h3>Background and Importance</h3> In Spain, leishmaniasis is caused by <i>Leishmania infantum</i>, whose main reservoirs are dogs or small mammals, transmitted through the bite of dipterian insects genus <i>Phlebotomus. Leishmania</i> infection causes disease ranging from localised cutaneous to visceral (VL), most severe form, affecting frequently profoundly immunocompromised individuals, such as late-stage HIV-infected patients, with high rates treatment failure, relapses, mortality....
<h3>Background and Importance</h3> Voriconazole is an antifungal agent with concentration-dependent activity high individual variability. It generally well tolerated. However, adverse effects (AEs) may occur, requiring dose reduction (DR) or discontinuation of treatment. <h3>Aim Objectives</h3> To describe the safety tolerability voriconazole treatment in a cohort patients admitted to tertiary hospital. <h3>Material Methods</h3> Retrospective observational study that included treated during...