A5028544979- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Nematode management and characterization studies
- Infective Endocarditis Diagnosis and Management
- Pharmaceutical studies and practices
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Analytical Methods in Pharmaceuticals
- Plant and soil sciences
- Pneumonia and Respiratory Infections
- Banana Cultivation and Research
- Streptococcal Infections and Treatments
- Entomopathogenic Microorganisms in Pest Control
- Patient Satisfaction in Healthcare
- Statistical Methods in Clinical Trials
- Plant Pathogens and Fungal Diseases
- Orthopedic Infections and Treatments
- Veterinary Pharmacology and Anesthesia
- Organizational Management and Innovation
- Pharmacogenetics and Drug Metabolism
- Psidium guajava Extracts and Applications
- Safe Handling of Antineoplastic Drugs
- Pneumocystis jirovecii pneumonia detection and treatment
- Artificial Intelligence in Healthcare and Education
Hospital Universitario Virgen del Rocío
2016-2024
Instituto de Biomedicina de Sevilla
2018-2024
Consejo Superior de Investigaciones Científicas
2022-2024
Instituto de Salud Carlos III
2023-2024
Universidad de Sevilla
2022-2024
Centro de Investigación Biomédica en Red
2023
Centre for Biomedical Network Research on Rare Diseases
2023
Barcelona Institute for Global Health
2021
The Metabolomics Innovation Centre
2014
Universidad Complutense de Madrid
2013
16S rRNA methyltransferases are an emerging mechanism conferring high-level resistance to clinically relevant aminoglycosides and have been associated with important mechanisms such as NDM-1. We sought genes encoding these enzymes in isolates highly resistant (MIC >200 mg/L) gentamicin amikacin from Indian hospital we additionally screened for the novel RmtF enzyme 132 UK containing NDM. All aminoglycoside-resistant were armA rmtA-E by PCR, cloning experiments performed negative genes....
To evaluate whether simplification of antiretroviral treatment to dual therapy (DT) negatively impacts immune recovery (IR), activation and inflammation (IA/I), HIV reservoir.An open-label, single-centre, randomized controlled trial conducted in adult virologically suppressed HIV-infected patients on triple (TT) with elvitegravir-cobicistat, emtricitabine tenofovir alafenamide or dolutegravir (DTG), abacavir, lamivudine (3TC). Participants were continue TT switch DTG, darunavir/cobicistat...
The inclusion of ampicillin-containing regimens in outpatient parenteral antimicrobial therapy programs (OPAT) depends upon solution stability under conditions similar to those experienced these programs. Lack this information could hinder the OPAT patients suffering from Enterococcus faecalis infective endocarditis treated with ampicillin plus ceftriaxone. purpose study is determine and ceftriaxone solutions a simulated setting conditions.
Ampicillin plus ceftriaxone (AC) is a well-recognized inpatient regimen for Enterococcus faecalis infective endocarditis (IE). In this regimen, usually administered 2 g every h (AC12). The administration of AC in outpatient parenteral antibiotic treatment (OPAT) programs challenging because multiple daily doses are required. regimens useful OPAT include once-daily high-dose (AC24) or co-diluted and jointly bolus 4 (ACjoined). retrospective analysis prospectively collected cases, we aimed to...
Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there a lack stability data combination both drugs in elastomeric devices, so inclusion AC Outpatient Parenteral Antimicrobial Therapy (OPAT) programs challenging. The objective study was to determine pumps when stored at 8 ± 2 °C, 25 30 °C and 37 using LC-MS/MS. diluted 0.9% sodium chloride final concentrations were 24 g/L g/L. Physical chemical evaluated...
Abstract Background Antimicrobial stewardship programs (ASPs) are recommended in nursing homes (NHs), although data limited. We aimed to determine the clinical and ecological impact of an ASP for NHs. Methods performed a cluster, randomized, controlled trial before–after study with interrupted time-series analyses 14 NHs 30 consecutive months from July 2018 December 2020 Andalusia, Spain. Seven facilities implemented bundle 5 educational measures (general ASP) 7 added 1-to-1 interviews...
Ceftriaxone administered as once-daily high-dose short infusion combined with ampicillin has been proposed for the treatment of Enterococcus faecalis infective endocarditis in outpatient parenteral antibiotic therapy programs (OPAT). This combination requires synergistic activity, but attainment ceftriaxone synergic concentration (Cs) regimen OPAT not studied. phase II pharmacokinetic study enrolled healthy adult volunteers who underwent two sequential phases. During A, received 2 g each 12...
Objective: The aim of this study was to assess the real use cefazolin for methicillin-susceptible S. aureus (MSSA) infective endocarditis (IE) in Spanish National Endocarditis Database (GAMES) and compare it with antistaphylococcal penicillins (ASP).Methods: Prospective cohort retrospective analysis a MSSA IE treated cloxacillin and/or cefazolin. Outcomes assessed were: relapse; intra-hospital, overall endocarditis-related mortality; adverse events. Risk renal toxicity each treatment...
Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy against Pseudomonas aeruginosa and other multidrug-resistant bacteria. However, it hindered by the lack of stability data for administration antibiotics under OPAT conditions. Our objective was to investigate nine antipseudomonal broad-spectrum beta lactam (aztreonam, cefepime, cefiderocol, ceftazidime, ceftazidime/avibactam, ceftolozane/tazobactam, meropenem, meropenem/vaborbactam, piperacillin/tazobactam)...
Cefazolin is a recommended treatment for methicillin-susceptible Staphylococcus aureus (MSSA) infections that has been successfully used in outpatient parenteral antibiotic therapy (OPAT) programs. The aim of this study was to assess the clinical outcomes cefazolin delivered each day (Group 24) vs. every two days 48) MSSA OPAT It prospective observational with retrospective analysis cohort attended OPAT. primary outcome success, defined as completing antimicrobial regimen without death,...
Vancomycin pharmacokinetic/pharmacodynamic (PK/PD) targets have not been validated in the neonatal population as no specifically designed studies are available. The main goal of this study was to analyze therapeutic vancomycin regimen, 24-h area under curve (AUC24), and trough plasma concentration (Ct) obtained that achieved clinical microbiological effectiveness a cohort neonates. This an observational, prospective, single-center covering period 2 years. Eligible patients were neonates...
Temocillin is an interesting alternative to carbapenems for susceptible Enterobacteriaceae. Although its use in outpatient parenteral antimicrobial therapy (OPAT) programmes has generated interest, this been hampered by the lack of stability data.The purpose present study was evaluate physical and chemical temocillin at recommended dose OPAT programmes, contained polypropylene infusion bags or polyisoprene elastomeric devices different temperatures, describe a novel LC-MS/MS developed...