A5087715642- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Bone and Joint Diseases
- Infectious Diseases and Tuberculosis
- Osteoarthritis Treatment and Mechanisms
- Hepatitis C virus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Psoriasis: Treatment and Pathogenesis
- Spine and Intervertebral Disc Pathology
- Health, Medicine and Society
- Diagnosis and treatment of tuberculosis
- Chronic Lymphocytic Leukemia Research
- Hip disorders and treatments
- Gout, Hyperuricemia, Uric Acid
- Biosimilars and Bioanalytical Methods
- Lower Extremity Biomechanics and Pathologies
- Musculoskeletal Disorders and Rehabilitation
- Orthopedic Infections and Treatments
- Liver Diseases and Immunity
Tunis El Manar University
2016-2025
Hôpital Charles-Nicolle
2016-2025
Tunis University
2016-2024
Faculté de médecine de Tunis
2022-2024
Hôpital La Rabta
2019
Hôpital Mongi Slim
2017
We aimed to assess the effects of a patient therapeutic education (PTE) programme on course disease and treatment management skills in rheumatoid arthritis (RA) patients treated with biologics. From January December 2023, 52 RA participated face-to-face session 1 h, delivered groups four six by 2 rheumatologists qualified PTE. Disease activity, quality life parameters patient's using BioSecure score were assessed before 3 months later. A statistically significant decrease mean pain visual...
Knee osteoarthritis, a chronic degenerative disease, is becoming public health problem around the world due to increasing life expectancy.We aimed assess impact of knee osteoarthritis on quality (QoL) patients and identify factors associated with impaired QoL.We conducted cross-sectional monocentric study including osteoarthritis. The pain was evaluated by Visual Analog Scale (VAS). short form injury Osteoarthritis Outcome Score (KOOS-PS) used functional impact. QoL assessed using...
Rheumatoid arthritis (RA) is a chronic inflammatory disease frequently associated with comorbidities such as cardiovascular diseases. RA patients are more prone to physical inactivity than the general population.
Introduction Spondyloarthritis (SpA) is a common rheumatic inflammatory disease and can impact patients’ work productivity. We aimed to evaluate the of pain catastrophizing central sensitization on outcomes in young SpA patients determine predictive factors productivity loss. Material methods performed cross-sectional study over 6 months. included aged between 18 50 years old, diagnosed with axial or peripheral SpA. Pain were assessed using Catastrophizing Scale (PCS) Central Sensitization...
Abstract Introduction Foot problems are very common in rheumatoid arthritis (RA). Podiatric intervention through therapeutic education of RA patients on the different potential foot could improve patients' knowledge and management their problems. This study aimed to evaluate podiatric related illness care practices. Methods was a cross‐sectional including diagnosed with aged older than 18 years. Sociodemographic data, disease characteristics, data were collected. practice assessed using...
COVID-19, caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to infection and has been suggested induce autoimmune phenomena. We report three cases of rheumatoid arthritis (RA) occurring after COVID-19 we present systematic review the literature RA post COVID-19. Our findings suggest that may be trigged in genetically predisposed individuals.
Background The aim of our study was to assess subclinical atherosclerosis in spondyloarthritis (SpA) by combining three ultrasound methods (flow-mediated dilation (FMD), carotid intima–media thickness (cIMT) and Ankle Brachial Index (ABI)) determine the predictive factors theses parameters. Methods This a case control conducted over 12 months including 47 patients with SpA-free-cardiovascular (CV) disease comparison age sex matched healthy controls. Sociodemographic, clinical biological...
Fibromyalgia may be associated to Spondyloarthritis with which it shares some common symptoms such as sleep disorders, fatigue and diffuse pain, leading diagnostic treatment dilemmas.We aimed determine the prevalence of fibromyalgia in axial spondyloarthritis how might influence assessments disease activity impact treatment.An observational cross-sectional study was conducted. The included 100 patients according Assessment SpondyloArthritis international Society criteria. diagnosed based on...
Abstract Background Rheumatoid arthritis (RA) is commonly associated with higher rates of comorbidities. Recent recommendations highlight screening comorbidities during the disease course because their impact on patients’ ability to function, outcome, but also treatment choices. Hence interest our study that aimed quantify among RA patients using a validated tool Rheumatic Disease Comorbidity Index (RDCI) and explore association between characteristics. Methods We conducted cross-sectional...
Single nucleotid polymorphisms (SNPs) of Fc-gamma receptors (FcgRs), by inducing a variation their affinity to the Fc-region immunoglobulins, might influence efficacy Fc-containing biologics prescribed in rheumatoid arthritis (RA). Our aim was investigate associations FCGR2A, FCGR3A and FCGR3B SNPs with TNF-inhibitors (TNFi)' response Tunisian RA patients.A cross-sectional, observational analytic multicentric cohort study conducted group 47 patients treated (etanercept [ETA], adalimumab...
To assess central sensitization in young patients with spondyloarthritis (SpA) and to study the associated factors higher scores.This was a cross-sectional including SpA (ASAS criteria) aged less than 50 years. For all patients, we collected sociodemographic disease characteristics data. Central assessed using validated tool: The Sensitization inventory (CSI). Pain status, fibromyalgia, quality of life, anxiety depression were screened by Brief pain inventory, Fibromyalgia rapid screening...
Familial Mediterranean Fever (FMF) is a hereditary auto inflammatory disease. The most common joint attack an acute large monoarthritis often affecting the knee or hip and lasting for several days. Rarely, more protracted arthritis may occur. Herein, we describe 47-year-old man with FMF in whom few years elapsed before definitive diagnosis could be made. patient presented, since age of 25, history recurrent episodes fever, abdominal pain, bloody diarrhea intermittent attacks bi-arthritis...
The concentrations of heavy metals (Fe, Zn, Pb and Mn) were determined in two green algae (Enteromorpha intestinalis Chaetomorpha Linium) collected from April 2012 to February 2013 nine stations characterized by the abundance these throughout year. Determination Pb, Mn Zn was carried out graphite furnace atomic absorption spectrometer while Fe flame (using Thermo Scientific ICE 3300 AA Spectrometer). An evaluation degree eutrophication is made through physicochemical study 31 samples surface...
Adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis constitute two sides of the same continuum disease. We aimed to investigate similarities differences between those diseases.We conducted a retrospective study including adult patients affected by still's disease, attending rheumatology department pediatric department. recorded clinical radiological findings, different therapeutic regimens, patterns.There were 8 (6 females 2 males) (4 4 males). The classical triad...
Leflunomide is a commonly used treatment for rheumatoid arthritis. It acts by inhibiting dihydroorotate dehydrogenase through its active metabolite teriflunomide. The objective of the study was to investigate relation between plasma-concentration teriflunomide and disease-activity in arthritis.Data were collected from patients with arthritis on stable leflunomide dose at least 2 months. Socio-demographic data, disease characteristics DAS28 score recorded. Blood samples taken determination...
Introduction:: Tumor necrosis factor alpha (TNF alpha) blockers such as infliximab (IFX) and adalimumab (ADA) had significantly changed the course of inflammatory diseases rheumatoid arthritis (RA), spondyloarthritis (SpA) Crohn's disease (CD). However, about 30% patients do not respond to these treatments. This lack response may be due formation antibodies against drugs (anti-drug antibodies: ADAbs). The aim this study was determine prevalence ADAbs IFX ADA, trough serum concentration ADA...
Objectives Nail unit is one of the targets ultrasound (US) assessment. We aimed to compare parameters clinically normal nail in psoriatic arthritis (PsA) patients with healthy controls (HC) and evaluate their correlations disease activity. Methods This was a cross‐sectional study including PsA matched HC. Tender (TJC) swollen joint count (SJC), Psoriasis Area Severity Index (PASI), Disease Activity Psoriatic Arthritis (DAPSA) were collected patients. Patients underwent US assessment...
<h3>Background:</h3> Quality of life (QoL) is a subjective measure encompassing various well-being indicators, including health, social interactions, and socioeconomic factors such as employment economic status. Spondyloarthritis patients often face pain, stiffness, physical limitations that can affect their professional stability. <h3>Objectives:</h3> This study aims to assess the impact work instability on quality in with spondyloarthritis. <h3>Methods:</h3> A prospective was conducted...
<h3>Background:</h3> Chronic low back pain (LBP) is one of the most common musculoskeletal disorders. It represents a healthcare issue as it often associated with loss work productivity and thus huge economic burden. Several physiotherapeutic strategies may be used during treatment. <h3>Objectives:</h3> To compare global postural reeducation (GPR) to conventional rehabilitation protocol for improving pain, flexibility, function, psychological impact in patients chronic LBP. <h3>Methods:</h3>...