L. Kharrat

ORCID: 0000-0002-0900-5516
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About
Contact & Profiles
Research Areas
  • Spondyloarthritis Studies and Treatments
  • Rheumatoid Arthritis Research and Therapies
  • Psoriasis: Treatment and Pathogenesis
  • Autoimmune and Inflammatory Disorders Research
  • Bone and Joint Diseases
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Musculoskeletal pain and rehabilitation
  • Inflammasome and immune disorders
  • Adolescent and Pediatric Healthcare
  • Osteoarthritis Treatment and Mechanisms
  • Dermatology and Skin Diseases
  • Gout, Hyperuricemia, Uric Acid
  • Myofascial pain diagnosis and treatment
  • Systemic Lupus Erythematosus Research
  • Vasculitis and related conditions
  • Sarcoidosis and Beryllium Toxicity Research
  • Total Knee Arthroplasty Outcomes
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Sphingolipid Metabolism and Signaling
  • Therapeutic Uses of Natural Elements
  • Hip disorders and treatments
  • Lymphadenopathy Diagnosis and Analysis
  • Pharmacological Effects and Toxicity Studies
  • Ocular Diseases and Behçet’s Syndrome
  • IgG4-Related and Inflammatory Diseases

Tunis El Manar University
2020-2024

Tunis University
2020-2024

Military Hospital of Tunis
2020-2024

Manouba University
2022-2024

Faculté de médecine de Tunis
2020-2024

Hôpital Charles-Nicolle
2021-2023

Hôpital Militaire Moulay Ismail
2019-2023

Institut des Hautes Études de Tunis
2021

Scoring systems for hip involvement in juvenile idiopathic arthritis exist, however, they were not used daily practice, and their reproducibility was proven. We aimed to determine the applicability, reliability, repeatability of two scoring patients. Two expert pediatrics rheumatologists analyzed pelvic radiographs from 25 children with JIA involvement. scored findings according previous valid (The childhood Arthritis Radiographic Score Hip newly developed score proposed by project...

10.3389/fped.2025.1436200 article EN cc-by Frontiers in Pediatrics 2025-03-28

The spectrum of Juvenile Idiopathic Arthritis (JIA) in Africa is still largely unknown. We thus set out to illustrate how we up the PAFLAR JIA registry and describe clinical profile across various regions Africa. carried a retrospective observational cohort study where collaborators were trained on use existing REDCAP database enter data for patients currently under their care capturing epidemiological data, features, laboratory investigations, diagnosis therapy at initial diagnosis....

10.1186/s12969-024-01000-3 article EN cc-by Pediatric Rheumatology 2024-07-22

Knee osteoarthritis, a chronic degenerative disease, is becoming public health problem around the world due to increasing life expectancy.We aimed assess impact of knee osteoarthritis on quality (QoL) patients and identify factors associated with impaired QoL.We conducted cross-sectional monocentric study including osteoarthritis. The pain was evaluated by Visual Analog Scale (VAS). short form injury Osteoarthritis Outcome Score (KOOS-PS) used functional impact. QoL assessed using...

10.2174/1573397119666230201152219 article EN Current Rheumatology Reviews 2023-02-01

Objectives We aimed to determine the discriminative values of pro-inflammatory cytokines distinguish spondyloarthritis patients from healthy subjects and assess association between these characteristics.

10.1080/1744666x.2024.2304080 article EN Expert Review of Clinical Immunology 2024-01-11

<title>Abstract</title> Background The spectrum of Juvenile Idiopathic Arthritis (JIA) in Africa is still largely unknown. We thus set out to describe the clinical-epidemiological profile across various regions Africa. Methods carried a retrospective observational cohort study where collaborators were trained on use existing PAFLAR REDCAP database enter data for JIA patients currently under their care capturing epidemiological data, clinical features, laboratory investigations, diagnosis and...

10.21203/rs.3.rs-3918846/v1 preprint EN Research Square (Research Square) 2024-02-21

Background: Whether land-or aquatic-based rehabilitation is more effective in improving knee osteoarthritis (OA) still unclear.This study assessed the effectiveness of treatments patients with OA.Methods: The participants were divided into a land-based exercise group (G1, n=30) and water-based (G2, n=30).The exercises performed for 8 weeks.The primary endpoint was response to physical therapy, defined as 20% decrease summed score Western Ontario McMaster Universities-Osteoarthritis Index...

10.4082/kjfm.23.0102 article EN cc-by-nc Korean Journal of Family Medicine 2024-08-22

The role of IL-22 in radiographic axial spondyloarthritis is not fully elucidated. Thus, there a need for new insights into this cytokine disease. We aimed to compare interleukin (IL)-22 level between spondyloarthritis, nonspecific-low back pain patients, and pain-free controls, evaluate associations characteristics.We conducted case-control study including 62 patients with (G1), 46 nonspecific low (G2), 42 healthy volunteers (G3). was measured using Enzyme-linked immunosorbent assay....

10.1080/1744666x.2023.2142563 article EN Expert Review of Clinical Immunology 2022-11-03

<ns4:p>Rheumatoid vasculitis (RV) is a rare but serious extra-articular manifestation of rheumatoid arthritis (RA). Its varied clinical presentation makes it hard to diagnose and treat. Hereby we describe case an aortitis revealing RV, which complication RA. A 56-year-old man with treated methotrexate presented fever, chest pain arthritis. Blood tests revealed inflammatory syndrome associated cholestasis. The diagnosis pericarditis was retained. Cholestasis mostly due methotrexate. patient...

10.12688/f1000research.26929.1 preprint EN cc-by F1000Research 2020-11-26

Background: The cardiovascular burden in inflammatory rheumatic diseases is well recognized. This has been reported spondyloarthritis. Atherogenic indexes are known with their role of predicting risk. Objectives: aim our study was to determine the relation between pro-inflammatory cytokines and atherogenic Methods: We performed a cross sectional including 38 patients spondyloarthritis according ASAS criteria. For each patient we measured interleukin (IL)1, IL6, IL17, IL23 tumor necrosis...

10.1136/annrheumdis-2021-eular.1281 article EN Annals of the Rheumatic Diseases 2021-05-19

of the right ulnar styloid.He had rheumatoid nodules on outer side both elbows.There were no skin ulcerations erythema nodosum.The rest physical examination was normal.

10.31038/ijot.2021412 article EN Deleted Journal 2021-02-15

<h3>Background</h3> Several studies reported that matrix metalloproteinase 3 (MMP-3), an enzyme of the proteolytic system, is implicated in pathogenesis and progression several rheumatic diseases [1]. <h3>Objectives</h3> We aimed to compare MMP-3 serum levels between spondyloarthritis (SpA) patients healthy controls. <h3>Methods</h3> conducted a case-control study, including 164 subjects divided into two groups, all matched for age gender: G1 82 SpA patients, diagnosed according ASAS 2009...

10.1136/annrheumdis-2023-eular.5668 article EN 2023-05-30

<h3>Background</h3> Several studies showed that the activity of proteinases, including matrix metalloproteinases (MMPs), is increased in inflamed tissue, via overproduction pro-inflammatory cytokines, spondyloarthritis (SpA) [1]. <h3>Objectives</h3> Our study aimed to assess correlation between serum levels MMP-3 and disease SpA. <h3>Methods</h3> We conducted a cross-sectional patients with SpA, diagnosed according ASAS 2009 criteria. ELISA technique was used measure levels. CRP ESR were...

10.1136/annrheumdis-2023-eular.5633 article EN Annals of the Rheumatic Diseases 2023-05-30

Abstract Introduction Inflammation plays a crucial role in impaired bone metabolism [1]. Subchondral marrow oedema (BME) Magnetic Resonance Imaging (MRI) was associated to mineral density (BMD) loss adult spondyloarthritis BME less studied juvenile idiopathic arthritis (JIA). Objectives We aimed study the link between MRI and BMD JIA patients. Methods conducted retrospective of 44 patients with who fulfilled International League Associations for Rheumatology (ILAR) 2001 criteria. For each...

10.1093/rheumatology/kead323.005 article EN Lara D. Veeken 2023-08-01
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