A5046889678- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Neurogenesis and neuroplasticity mechanisms
- Nerve Injury and Rehabilitation
Medizinische Hochschule Hannover
2019-2022
Tension-free surgical reconstruction of transected digital nerves in humans is regularly performed using autologous nerve grafts (ANGs) or bioartificial grafts. Nerve with increased bendability are needed to protect regenerating highly mobile extremity parts. We have recently demonstrated and regeneration supporting properties chitosan guides a corrugated outer wall (corrCNGs) the common rat sciatic model (model low-mobility). Here, we further modified hollow corrCNGs into two-chambered by...
In the current study we investigated suitability of a novel hyaluronic acid-laminin hydrogel (HAL) as luminal filler and carrier system for co-transplanted cells within composite chitosan-based nerve graft (CNG) in rat critical defect model. The HAL was meant to improve performance our artificial guides by giving additional structural molecular support regrowing axons. We filled hollow CNGs or two-chambered with an inserted longitudinal chitosan film (CNG[F]s), cell-free HA additionally...
Background The rabbit sciatic nerve injury model may represent a valuable alternative for critical gap distance seen in humans but often leads to automutilation. In this study, we modified the complete avoiding autophagy. Materials and Methods 20 adult female New Zealand White rabbits, instead of transecting nerve, unilaterally transected tibial portion preserved peroneal portion. Thereby loss sensation dorsal aspect paw was avoided. repaired reversed autograft approach length 2.6 cm. an...