A5045793546- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Distributed and Parallel Computing Systems
- Pharmacogenetics and Drug Metabolism
- Aquatic Ecosystems and Phytoplankton Dynamics
- Drug-Induced Hepatotoxicity and Protection
- Tea Polyphenols and Effects
- Advanced Database Systems and Queries
- Histone Deacetylase Inhibitors Research
- Advanced Data Storage Technologies
- Cancer-related Molecular Pathways
- Genetic and Kidney Cyst Diseases
- Liver Diseases and Immunity
- Global Cancer Incidence and Screening
- Software System Performance and Reliability
- Piperaceae Chemical and Biological Studies
- Atmospheric Ozone and Climate
- Pharmacological Effects and Toxicity Studies
- Sustainable Design and Development
- Diet, Metabolism, and Disease
- Sustainable Building Design and Assessment
- Hepatitis B Virus Studies
- Glutathione Transferases and Polymorphisms
- Cloud Computing and Resource Management
Washington State University Spokane
2014-2025
Washington State University
2019-2024
Tharawal Aboriginal
2024
The Open University
2023
City of Hope
2021
University of Washington
2021
Duke Cancer Institute
2021
Duke Medical Center
2021
Cornerstone Systems Northwest (United States)
2014-2020
University of Kansas Medical Center
2019
Background: Tobacco control efforts implemented in the United States since 1960s have led to considerable reductions smoking and smoking-related diseases, including lung cancer. Objective: To project tobacco use cancer mortality from 2015 2065 due existing efforts. Design: Comparative modeling approach using 4 simulation models of natural history that explicitly relate temporal patterns rates. Setting: U.S. population, 1964 2065. Participants: Adults aged 30 84 years. Measurements: Models...
Abstract Scope: Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts a chemoprevention agent. chemopreventive agent specifically cause cytotoxicity in cancer and not normal cells important factor determining its safety clinical relevance. Methods results: We characterized the effects (PrEC), benign hyperplasia (BPH1) cancerous (LnCap PC3) prostate...
N-linked glycosylation of proteins is critical for proper protein folding and trafficking to the plasma membrane. Drug transporters are one class that have reduced function when impaired. has also been investigated as a biomarker several liver diseases, including non-alcoholic fatty disease (NAFLD). The purpose this study was assess transcriptomic expression genes involved in processing glycosylation, determine status key drug during human NAFLD progression.
Proteases play essential roles in the process of tumor invasion and metastasis. The serine protease stratum corneum chymotryptic enzyme (SCCE) has been purified from human is known to contribute cell shedding by catalyzing degradation intercellular cohesive structures at skin surface. presence SCCE on surface cells suggests it also may shedding, resulting early metastasis carcinoma.Gene expression was investigated 44 ovarian tumors (12 low malignant potential 32 carcinomas) 10 normal ovaries...
Horseradish peroxidase- (HRP) filled microelectrodes have been used to examine the anatomy and physiology of "commissural interneurons," a morphologically defined class spinal cord interneuron in Xenopus laevis embryos. Commissural interneurons unipolar cell bodies dorsal half cord. Their dendrites lie mid ventral parts lateral tracts their axons cross ventrally, T branch, ascend descend on opposite side Recordings were made from animals immobilized tubocurarine responding natural...
Increased consumption of cruciferous vegetables such as broccoli may reduce the risk various cancers. Myrosinase is required to convert dietary glucosinolates from into bioactive isothiocyanates. We evaluated isothiocyanate excretion profiles in healthy subjects who consumed sprouts or supplement (no myrosinase) with equivalent glucosinolate content. Urinary metabolites two major isothiocyanates, sulforaphane and erucin, were measured by liquid chromatography coupled tandem mass...
Nonalcoholic fatty liver disease is a prevalent form of chronic that can progress to the more advanced stage nonalcoholic steatohepatitis (NASH). NASH has been shown alter drug transporter regulation and may have implications in development adverse reactions. Several experimental rodent models proposed for study NASH, but no single model fully recapitulates all aspects human disease. The purpose current was determine which best reflects known alterations expression enable accurate...
Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, alterations liver function can place individuals at greater risk for adverse reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes expression localization responsible disposition numerous drugs. The purpose this study was determine effect NASH on methotrexate (MTX) resulting toxicity profile. Sprague Dawley rats were fed either control or...
ABSTRACT The recent ICH M12 guidance on Drug Interaction Studies encourages the use of alternate approaches for predicting drug-drug interaction (DDI) potential new chemical entities. One approach involves biomarkers, which are endogenous substrates drug metabolizing enzymes and transporters (DMET) can be used to assess inhibitory entities during Phase 1 clinical studies. Thus, biomarkers could potentially eliminate need dedicated DDI studies with exogenous probe substrates. Metabolomics, in...
Morphine is metabolized in humans to morphine-3-glucuronide (M3G) and the pharmacologically active morphine-6-glucuronide (M6G). The hepatobiliary disposition of both metabolites relies upon multidrug resistance-associated proteins Mrp3 Mrp2, located on sinusoidal canalicular membrane, respectively. Nonalcoholic steatohepatitis (NASH), severe stage nonalcoholic fatty liver disease, alters xenobiotic metabolizing enzyme transporter function. purpose this study was determine whether NASH...
Simvastatin (SIM)-induced myopathy is a dose-dependent adverse drug reaction (ADR) that has been reported to occur in 18.2% of patients receiving 40- 80-mg dose. The pharmacokinetics SIM hydroxy acid (SIMA), the bioactive form SIM, and occurrence SIM-induced are linked function organic anion transporting polypeptide (Oatp) hepatic uptake transporters. Genetic polymorphisms SLCO1B1, gene for human OATP1B1, cause decreased elimination SIMA increased risk developing myopathy. Nonalcoholic...
Objective The factor structure of the Children's Eating Attitudes Test (ChEAT) and predictors problem eating were examined in young boys girls. Methods Two hundred twenty eight children from Grades 2 4 completed questionnaires which attitudes behaviors, body image, self-concepts. Results Four factors found for girls boys. girls' four factors, Dieting, Food Preoccupation, Social Pressure to Eat, Restricting Purging, corresponded closely previous studies with older women. different boys,...
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) and major cause cirrhosis hepatic failure. The methionine choline-deficient diet (MCD) frequently used hepatotoxicity animal model NASH that induces transaminase (ALT, AST) elevations hepatobiliary histological changes similar to those observed in human NASH. Liver-specific microRNA-122 (miR-122) has been shown as key regulator cholesterol acid metabolism adult liver, recently proposed...
Cruciferous vegetables have been associated with the chemoprevention of cancer. Epigenetic regulators identified as important targets for prostate cancer chemoprevention. Treatment human cells sulforaphane (SFN), a chemical from broccoli and sprouts, inhibits epigenetic such histone deacetylase (HDAC) enzymes, but it is not known whether consumption diet high in sprouts impacts mechanisms an vivo model In transgenic adenocarcinoma mouse (TRAMP) model, we tested hypothesis that sprout...