A5046079625- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Mast cells and histamine
- Synthesis and Biological Evaluation
- Blood groups and transfusion
- Protein Kinase Regulation and GTPase Signaling
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
John Radcliffe Hospital
2012-2023
University of Oxford
2012-2023
Medical Research Council
2012-2023
MRC Human Immunology Unit
2018
MRC Weatherall Institute of Molecular Medicine
2018
Radboud University Nijmegen
2010
Radboud University Medical Center
2010
Bipar
2006
University of Amsterdam
1989
Abstract Purpose: The success of cancer immunotherapy depends on the balance between effector T cells and suppressive immune regulatory mechanisms within tumor microenvironment. In this study we investigated whether transient monoclonal antibody–mediated depletion CD25high (Treg) is capable enhancing immunostimulatory efficacy dendritic cell vaccines. Experimental Design: Thirty HLA-A2.1+ metastatic melanoma patients were vaccinated with mature pulsed peptide keyhole limpet hemocyanin (KLH)....
Abstract T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, must overcome the highly charged, barrier-like layer of large molecules forming a target cell’s glycocalyx. Here, are observed microvilli breach model glycocalyx barrier, numerous small (<0.5 μm diameter) contacts each which stabilized by adhesive protein CD2 expressed cell, and excludes proteins including CD45, allowing sensitive, antigen...
Exclusion of a phosphatase from regions antigen-receptor engagement facilitates mast cell activation.
Lack of understanding the nature and physiological regulation γδ T cell ligands has considerably hampered full function these cells. We developed an unbiased approach to identify human cells by production a soluble TCR-γδ (sTCR-γδ) tetramer from synovial Vδ1 clone Lyme arthritis patient. The sTCR-γδ was used in flow cytometry initially define spectrum ligand expression both tumor lines certain primary Analysis diverse revealed high on several epithelial or fibroblast origin, whereas those...