A5101439882- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Microbial Natural Products and Biosynthesis
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Biochemical and Structural Characterization
- Neuropeptides and Animal Physiology
- Protein Kinase Regulation and GTPase Signaling
- Glycosylation and Glycoproteins Research
- Protein Hydrolysis and Bioactive Peptides
- Asymmetric Synthesis and Catalysis
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- IoT-based Smart Home Systems
- Collagen: Extraction and Characterization
- Alzheimer's disease research and treatments
- Water Quality Monitoring Technologies
- Mobile Ad Hoc Networks
- Advanced Software Engineering Methodologies
- Diabetes Treatment and Management
- Asymmetric Hydrogenation and Catalysis
- Eicosanoids and Hypertension Pharmacology
- Barrier Structure and Function Studies
- Alkaloids: synthesis and pharmacology
University of Auckland
2007-2020
General Department of Preventive Medicine
2019
Maurice Wilkins Centre
2011-2017
Baba Farid University of Health Sciences
2017
Ansys (United States)
2017
Rayat Bahra University
2016
The first total synthesis of YM-280193, a cyclic depsipeptide that inhibits the ADP-induced aggregation human platelets, is described. monomer and dipeptide fragments were prepared using conventional chemistry subsequently assembled by Fmoc-solid-phase peptide (Fmoc-SPPS). A late-stage novel bis-alkylation–elimination cysteine on-resin was employed to introduce unnatural N-methyldehydroalanine moiety. final step involved execution key macrolactamization reaction between hindered...
ConspectusIn nature, proteins, lipids, and nucleic acids can nonenzymatically react with sugars sugar degradation products to give rise a diverse range of modifications, known as advanced glycation endproducts (AGEs). These AGEs typically occur at lysine arginine residues long-lived such collagen, modify the structure function native protein. accumulate during normal aging process, AGE formation is dramatically accelerated diabetes. have also been implicated in wide debilitating conditions...
Dehydrotryptophan and its derivatives are non-proteinogenic amino acids commonly found in peptide-based natural products produced by microorganisms, marine organisms plants. These secondary metabolites formed post translational modification processes. Although comprehensive reviews on the synthesis of dehydroamino available, this perspective focuses solely methods to synthesise dehydrotryptophan-containing segment naturally occurring peptides, their derivatives.
The first syntheses of the naturally occurring cyclic peptides dianthin I (1), pseudostellarin A (2), and heterophyllin J (3) are described. linear protected peptide precursors were prepared efficiently via Fmoc-solid-phase synthesis subsequently cyclized in solution under dilute conditions. structures synthetic cyclopentapeptides confirmed by NMR spectroscopy mass spectrometry agreement with literature data reported for natural products.
Synthetic clicked pramlintide glycomimetics maintained AMY<sub>1(a)</sub>activity and are expected to possess superior synthetic pharmacokinetic properties than<italic>N</italic>-glycosylated analogues.
The first total synthesis of psychrophilin E, a potent antiproliferative cyclic tripeptide isolated from Aspergillus versicolor ZLN-60, is reported herein. Key features the include installation an amide bond between indole-nitrogen tryptophan and anthranilic acid residue, high yielding macrolactamization linear to desired macrocycle.
Herein we describe the first synthesis of all-<sc>l</sc> naturally occurring cyclopentapeptides versicoloritides A, B, and C. We found that extent oligomerization epimerization upon head-to-tail cyclization linear pentapeptide precursors could be reduced to acceptable levels by modifying reaction conditions.
The first synthesis of the cyclic peptides tunicyclins C and D is described. Tunicyclin a potent antifungal agent, isolated from traditional Chinese medicinal herb.
A striking decrease in thermal stability was observed upon incorporation of triazole-linked galactosylated-lysine into an adiponectin model peptide, suggesting possible applications ‘click’ glycomimetics bioengineering.
A wireless sensor network (WSN) is a of nodes located at unattended areas.Nodes in sense parameters from environment and send data to sink.Movable sink take number rounds predict parameters.Movable performs better than static as it saves energy lifetime network.WSN do not have fixed architecture but battery constrained.As WSN can perform multi tasking agents effectively solve these problems it.In this paper proposes genetic algorithm that plans the simultaneous itineraries intelligent mobile...
Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases.
Abstract Pericyte loss is correlated with blood‐brain barrier leakage in neurological disorders such as Alzheimer's disease. The platelet‐derived growth factor receptor β (PDGFRβ)/platelet‐derived BB (PDGF‐BB) signalling pathway key to the regulation of pericyte survival and proliferation. A series peptide dimers mimicking ligand PDGF‐BB were prepared hope stimulating PDGFRβ internalisation activation this pathway. Copper‐catalysed azide‐alkyne cycloaddition monomers PEGylated linkers...
Review: 27 refs.
Abstract Review: 52 refs.