A5026562618- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Neuroscience of respiration and sleep
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Sleep and Work-Related Fatigue
- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Erythropoietin and Anemia Treatment
- Memory and Neural Mechanisms
- Impact of Light on Environment and Health
- Biochemical Analysis and Sensing Techniques
- Temporomandibular Joint Disorders
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
National Institute of Mental Health
2017-2024
Charles University
2019-2024
Karlovac University of Applied Sciences
2019
In some patients, it is difficult to correctly nosologically classify daytime sleepiness. Clinical manifestations may be nonspecific; on the basis of objective measures possible determine current severity sleepiness, but they do not always allow accurate diagnosis. It especially distinguish between idiopathic hypersomnia (IH) and associated with a psychiatric disorder (PSY).
Idiopathic rapid eye movement sleep behavior disorder (iRBD) affects 1–2% of people over 60 years age and presents a high risk developing neurodegenerative from the group synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies multiple system atrophy. Therefore, screening tools are needed. In 2007, questionnaire (RBD-SQ) was developed has been translated into several languages. The aim study to assess validity reliability Czech version RBD-SQ in mixed population clinic...
Recurrent isolated sleep paralysis (RISP) is a rapid eye movement (REM) parasomnia characterized by dissociative state with characteristics of REM and wakefulness. Pathophysiology has not yet been clarified very little research performed using objective polysomnographic measures inconsistent results. The main aim our study was to find whether higher fragmentation consistent the theory dissociation or signs can be detected spectral analysis. A total 19 participants in RISP group age-...
We have verified the eligibility of Idiopathic Hypersomnia Severity Scale (IHSS) as a basic clinical tool for determining subjective severity illness in patients with idiopathic hypersomnia (IH) Czech Republic. Total 37 diagnosis IH (9 men, 28 women, mean age 40.2 ± 12.8) completed IHSS scale. At same time, they were instructed to complete Epworth Sleepiness (ESS), Fatigue (FSS), Hospital Anxiety and Depression Scales (HADS-A HADS-D), short version Quality Life Questionnaire (SF-36). The...
Pregnancy is often associated with reduced sleep quality and an increase in disorders, such as restless leg syndrome, obstructive apnea, insomnia. There are few studies investigating the prevalence of parasomnias pregnancy, although they may be expected to a significant problem, disturbed this time period addition these disorders trigger parasomnia episodes.We conducted survey using online questionnaire focusing on comparison three periods: 3 months before during after delivery. We also...
NREM parasomnias also known as disorders of arousal (DOA) are characterised by abnormal motor and autonomic activation during arousals primarily from slow wave sleep. Dissociative state between sleep wake is likely responsible for clinical symptoms DOA. We therefore investigated potential dissociation outside parasomnic events using simultaneous 256-channel EEG (hdEEG) functional magnetic resonance imaging (fMRI).Eight DOA patients (3 women, mean age = 27.8; SD 4.2) 8 gender matched healthy...
Abstract Background Isolated REM sleep without atonia (RSWA) as a main polysomnograhic feature of behaviour disorder (RBD) is thought to be prodromal or subclinical state the disease. RSWA/RBD occurence in psychiatric population much more frequent than general but its associated factors are still not known. Methods We invited 88 psychiatry in-patients undervent video-polysomnography. The visual scoring was focused on RSWA submentales and flexores digitales superficiales muscles. This...
Mental activity in sleep often involves visual and auditory content. Chemosensory (olfactory gustatory) experiences are less common underexplored. The aim of the study was to identify olfaction-related factors that may affect occurrence chemosensory dream Specifically, we investigated effects all-night exposure an ambient odour, participants' appraisal their current olfactory environment, general propensity notice odours act on them (i.e., odour awareness), acuity. Sixty pre-screened healthy...
Functional magnetic resonance imaging (fMRI) techniques and electroencephalography (EEG) were used to investigate sleep with a focus on impaired arousal mechanisms in disorders of (DOAs). With prevalence 2–4% adults, DOAs are significant that currently gaining attention among physicians. The paper describes simultaneous EEG fMRI experiment conducted adult individuals (n=10). Both data validated by reproducing well established associations. A method for identification both brain functional...
Background Gait disturbances have emerged as some of the main therapeutic concerns in late-stage Parkinson’s disease (PD) treated with dopaminergic therapy and deep brain stimulation (DBS). External cues may help to overcome freezing gait (FOG) improve parameters. Aim To evaluate effect 3D visual STN-DBS on PD group. Methods We enrolled 35 patients DBS nucleus subthalamicus (STN-DBS). Twenty-five (5 females; mean age 58.9 ±6.3) 25 sex- age-matched controls completed examination. The 10...
Abstract Emotions experienced within sleep mentation (dreaming) affect mental functioning in waking life. There have been attempts at enhancing dream emotions using olfactory stimulation. Odors readily acquire affective value, but to profoundly influence emotional processing, they should bear personal significance for the perceiver rather than be generally pleasant. The main objective of present laboratory study was examine whether prolonged nocturnal exposure self-selected, preferred...
Introduction Recurrent isolated sleep paralysis (RISP) is a rapid eye movement (REM) parasomnia, characterized by the loss of voluntary movements upon onset and/or awakening with preserved consciousness. Evidence suggests microstructural changes in RISP, although mechanism this difference has not been clarified yet. Our research aims to identify potential morphological brain that can reflect these regulations. Materials and methods We recruited 10 participants RISP (8 women; mean age 24.7...
Abstract Background Sleep is important for consolidating declarative memory. Hippocampus considered an structure in this process. Our goal was to assess relationship between sleep structure, memory and size of the hippocampus. Method 18 patients (4 men, age range 60 ‐ 80 years) underwent polysomnography, neuropsychological examination brain MRI (3 T). efficiency, percentages REM non‐REM stages were calculated. Delayed recall score Rey Auditory Verbal Learning Test (RAVLT) used Size...
Modafinil may affect autonomic functions in healthy subjects. The aim of the study was to assess long-term modafinil administration influence on cardiac reactivity orthostatic load patients with narcolepsy type 1.In 15 (4 male; 11 female; median age, 47 years; range, 18-70 years) 1 treated daily dose 100 300 mg, short-term spectral analysis heart rate variability (HRV) supine-standing-supine test performed before and after 72 hours discontinuation.The sympathovagal not modified by treatment;...
Potíže se spánkem patří k častým zdravotním problémům seniorů.Ve věku nad 65 let typicky setkáváme jednak s primárními poruchami spánku, ale také které vznikají v důsledku komorbidních interních či psychiatrických onemocnění souvislosti jejich léčbou.Cílem tohoto sdělení je popsat fyziologické změny spánku u seniorů, podat přehled nejčastějších poruch a představit