A5002060265- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Photochromic and Fluorescence Chemistry
- Chemokine receptors and signaling
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Porphyrin and Phthalocyanine Chemistry
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Inorganic and Organometallic Chemistry
- Luminescence and Fluorescent Materials
- Multicomponent Synthesis of Heterocycles
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
King Saud bin Abdulaziz University for Health Sciences
2018-2024
National Guard Health Affairs
2018-2024
King Abdullah International Medical Research Center
2018-2024
King Abdulaziz Medical City
2020-2022
GP Batteries (China)
2020
Robert Bosch (Germany)
2020
Laboratoire de Chimie Moléculaire et Thioorganique
2020
Lithium Power (United States)
2020
Biocon (India)
2018
Bristol-Myers Squibb (India)
2018
The CC chemokine receptor-1 (CCR1) is a prime therapeutic target for treating autoimmune diseases. Through high capacity screening followed by chemical optimization, we identified novel non-peptide CCR1 antagonist, R-<i>N</i>-[5-chloro-2-[2-[4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]urea hydrochloric acid salt (BX 471). Competition binding studies revealed that BX 471 was able to displace the ligands macrophage inflammatory protein-1α (MIP-1α), RANTES, and...
The CC chemokines macrophage inflammatory protein-1α (MIP-1α) and RANTES (regulated on activation normal T cell expressed) have been implicated in rheumatoid arthritis multiple sclerosis. Since their effects are mediated through the CCR1 chemokine receptor, we set up a small molecule antagonist program to search for inhibitors. Through high capacity screening discovered number of 4-hydroxypiperidine compounds with activity report synthesis <i>in vitro</i> pharmacology here. Scatchard...
A series of novel 24 phenylhydrazono phenoxyquinoline derivatives were synthesized with moderate to excellent yield and screened for their efficacy against the α-amylase enzyme through in silico studies. The structures characterized using spectroscopic techniques such as 1HNMR, 13CNMR, HREI-MS. Comprehensive computational studies including, drug-likeness ADMET profiling, quantum chemical calculations, molecular docking, dynamics (MD) simulation studies, performed. density functional theory...
Assembling molecular machines into crystals provides a way to harness their power on large length scales, but the development of crystal analogue motor remains challenge. The molecule (
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agentsImadul Islam, Edward B. Skibo, Robert T. Dorr, and David S. AlbertsCite this: J. Med. Chem. 1991, 34, 10, 2954–2961Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October...
A combined experimental/computational analysis of photomechanical anthracene derivatives reveals their kinetic behavior is not simply related to the monomer-photodimer energetics.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity studies of benzimidazole-based DNA-cleaving agents. Comparison benzimidazole, pyrrolobenzimidazole, and tetrahydropyridobenzimidazole analogsEdward B. Skibo, Imadul Islam, Matthew J. Heileman, William G. SchulzCite this: Med. Chem. 1994, 37, 1, 78–92Publication Date (Print):January 1994Publication History Published online1 May 2002Published inissue 1 January...
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor (GPCR) superfamily and mediate several physiological responses, such as blood pressure, food intake, sedation memory retention. To understand interactions between NPY Y1 subtype its ligands, computer modeling was applied natural peptide agonist, a small molecule antagonist, BIBP3226. An agonist antagonist binding domain elucidated using mutagenesis data for well other GPCR families. The ligands which were investigated...
Abstract Pyridinium chlorochromate (PCC) has been found to be selective reagent for the oxidative cleavage of enol ethers esters or keto lactones in high yields.
Ligands for the CCR1 receptor (MIP-1alpha and RANTES) have been implicated in a number of chronic inflammatory diseases, most notably multiple sclerosis rheumatoid arthritis. Because these ligands share common receptor, CCR1, we sought to discover antagonists this as an approach treating disorders. A novel series 4-hydroxypiperidines has discovered by high throughput screening (HTS) which potently inhibits binding MIP-1alpha RANTES recombinant human chemokine receptor. The structure-activity...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrrolo[1,2-a]benzimidazole-Based Quinones and Iminoquinones. The Role of the 3-Substituent on CytotoxicityWilliam G. Schulz, Imadul Islam, Edward B. SkiboCite this: J. Med. Chem. 1995, 38, 1, 109–118Publication Date (Print):January 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/jm00001a016https://doi.org/10.1021/jm00001a016research-articleACS PublicationsRequest reuse...
Cinnamalmalononitrile (CM) derivatives have been shown to exhibit a strong photomechanical response in the crystal form. In this paper, effects of fluorine substitution on molecular properties, packing, and solid-state photochemical reactivity family photochromes are explored. The addition fluorines shifts S0 – S1 gap higher energy up 0.4 eV. Fluorination also enables polymorphism some that effectively controls whether or not they can undergo [2 + 2] photodimerization. Depending pattern,...
In this study, a focused library of oxime ester derivatives 2,4-dichloro-5-sulfamoylbenzoic acid (lasamide) containing Schiff bases was synthesized and tested in vitro for their ability to inhibit the cytosolic human carbonic anhydrases (hCAs) I II, as well transmembrane tumor-associated IX XII isoforms. As result, we obtained first line knowledge on lasamide potentially useful development CA inhibitors (CAIs). particular, our attention derivative 11, which selective toward hCAs over...
In this study, we report the first example of a nonpeptide chemokine receptor agonist, 2-{2-[4-(3-phenoxybenzyl)piperazin-1-yl]ethoxy}ethanol (ZK 756326), for CC CCR8. ZK 756326 inhibited binding CCR8 ligand I-309 (CCL1), with an IC<sub>50</sub> value 1.8 μM. Furthermore, was full agonist CCR8, dose-responsively eliciting increase in intracellular calcium and cross-desensitizing response to CCL1. addition, stimulated extracellular acidification cells expressing human The ability induce...
Hollow organic molecular cocrystals comprised of 9-methylanthracene-1,2,4,5-tetracyanobenzene (9MA-TCNB) and naphthalene-1,2,4,5-tetracyanobenzene (NAPH-TCNB) were fabricated using a surfactant-mediated co-reprecipitation method. The crystals exhibit narrow size distribution that can be easily tuned by varying the concentration surfactant incubation temperature. rectangular possess symmetrical twinned cavities with an estimated storage volume on order 10-10 L. An aqueous dye solution...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and physical studies of azamitosene iminoazamitosene reductive alkylating agents. Iminoquinone hydrolytic stability, syn/anti isomerization, electrochemistryImadul Islam Edward B. SkiboCite this: J. Org. Chem. 1990, 55, 10, 3195–3205Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 1990https://pubs.acs.org/doi/10.1021/jo00297a040https://doi.org/10.1021/jo00297a040research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general approach to the synthesis of butanolides: sex pheromone Japanese beetleSundarababu Baskaran, Imadul Islam, and Srinivasan ChandrasekaranCite this: J. Org. Chem. 1990, 55, 3, 891–895Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00290a018https://doi.org/10.1021/jo00290a018research-articleACS PublicationsRequest reuse...
Summary We have discovered a novel small-molecule (3-phosphinoylpropionic acid) inhibitor of activated thrombin activatable fibrinolysis (TAFIa), BX 528, which had an IC50 2 nM in enzymatic assay and 50 in-vitro clot lysis assay, with 3,500- to 35,000-fold selectivity against other carboxypeptidases, such as CPN, CPZ CPD, 5- 12-fold CPE (CPH) CPB, respectively. At 10 µM, 528 no significant activity (< 50% inhibition or antagonism) panel 137 enzymes receptors. It effects on blood...