A5002085983- Sex and Gender in Healthcare
- Diversity and Career in Medicine
- Intimate Partner and Family Violence
- Liver Diseases and Immunity
- Sexual Assault and Victimization Studies
- Workplace Violence and Bullying
- Liver Disease Diagnosis and Treatment
- Health Promotion and Cardiovascular Prevention
- Gender Roles and Identity Studies
- Adolescent Sexual and Reproductive Health
- Obesity and Health Practices
- Migration, Health and Trauma
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Attachment and Relationship Dynamics
- Cardiac Health and Mental Health
- Health and Medical Studies
- Gender Diversity and Inequality
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- COVID-19 Impact on Reproduction
- Diabetes and associated disorders
- Economic and Financial Impacts of Cancer
- Systemic Lupus Erythematosus Research
Radboud University Nijmegen
2017-2024
Bielefeld University
2021-2024
Radboud University Medical Center
2017-2024
Community Care
2017-2023
University Medical Center
2017-2023
Mayo Clinic in Florida
2022
Charité - Universitätsmedizin Berlin
2012-2021
Landscape Research Group
2021
RELX Group (Netherlands)
2021
RELX Group (United States)
2021
The ongoing pandemic caused by SARS-CoV-2, the causal agent of acute respiratory distress syndrome COVID-19, is placing unprecedented stress on healthcare systems and societies as a whole. rapid spread virus in absence targeted therapies or vaccine, forcing countries to respond with strong preventative measures ranging from mitigation containment. In extreme cases, quarantines are being imposed, limiting mobility varying degrees. While an effective measure infection control, they can lead...
Abstract Sex and gender differences impact the incidence of SARS-CoV-2 infection COVID-19 mortality. Furthermore, sex influence frequency severity pharmacological side effects. A large number clinical trials to develop new therapeutic approaches vaccines for are ongoing. We investigated inclusion and/or in studies on ClinicalTrials.gov, collecting data period January 1, 2020 26, 2021. Here, we show that 4,420 registered SARS-CoV-2/COVID-19 studies, 935 (21.2%) address sex/gender solely...
Abstract Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by lymphocytic infiltrates in portal tracts, selective destruction epithelial cells, and anti-mitochondrial Abs (AMAs). The elucidation early events induction tissue inflammation autoimmunity PBC has been hampered cryptic onset disease, practical limitations accessing target tissue, lack a suitable animal model. We demonstrate this study that mouse transgenic for directed expression...
Humans with primary biliary cirrhosis (PBC), a disease characterized by the destruction of small bile ducts, exhibit signature autoantibodies against mitochondrial Pyruvate Dehydrogenase Complex E2 (PDC-E2) that crossreact onto homologous enzyme Novosphingobium aromaticivorans, an ubiquitous alphaproteobacterium. Here, we show infection mice N. aromaticivorans induced antibodies microbial PDC-E2 and its counterpart but also triggered chronic T cell-mediated autoimmunity ducts. Disease...
Abstract The antimitochondrial response in primary biliary cirrhosis (PBC) is the most highly directed and specific self-reacting antibody human immunopathology. Originally, antibodies (AMAs) were detected by indirect immunofluorescence (IIF) found approximately 90% of well-documented patients with PBC. introduction recombinant autoantigens use immunoblotting have increased sensitivity specificity AMAs, they are now considered positive 95% Clearly, accurate autoantibody detection represents...
Rebecca C. Thurston, PhD; Yuefang Chang, Karen A. Matthews, Roland von Känel, MD; Karestan Koenen, PhD
Recent work has demonstrated enhanced X monosomy in women with primary biliary cirrhosis (PBC) as well two other female-predominant autoimmune diseases, systemic sclerosis and thyroid disease. To further our understanding of these events, we have investigated the mechanisms chromosome loss inactivation (XCI) 166 PBC 226 rigorously age-matched healthy liver disease controls. analysis determination pattern was performed by quantitative fluorescent polymerase chain reaction (QF-PCR) 4 X-linked...
There is strong need to develop the current stratified practice of CVD management into a better personalized cardiovascular medicine, within broad framework global patient care. Clinical information obtained from history and physical examination, functional imaging studies, biochemical biomarkers, genetic/epigenetic data, pathophysiological insights disease-driving processes be integrated new taxonomy CVDs allow disease management. This has potential for major health benefits population...
Background: A new modular, outcome-based, interdisciplinary curriculum was introduced for undergraduate medical education at one of the largest European faculties. key stated institutional goal to systematically integrate sex and gender medicine perspectives into in order foster adequate gender-related knowledge skills future doctors concerning etiology, pathogenesis, clinical presentation, diagnosis, treatment, research diseases. Methods: change agent integrated directly development team...
The incorporation of sex and gender-specific analysis in medical research is increasing due to pressure from public agencies, funding bodies, the clinical community. However, generations knowledge publication trends this discipline are currently spread over distinct specialties difficult analyze comparatively. Using a text-mining approach, we have analysed gender aspects within nine subspecialties - Cardiology, Pulmonology, Nephrology, Endocrinology, Gastroenterology, Haematology, Oncology,...
Awareness represents a major modulator for the uptake of preventive measures and healthy life-style choices. Women underestimate role cardiovascular diseases as causes mortality, yet little information is available about their subjective risk awareness. The Berlin Female Risk Evaluation (BEFRI) study included randomized urban female sample aged 25–74 years, in which 1,066 women completed standardized questionnaires attended an extensive clinical examination. Subjective estimation was...
The year 2016 has marked the highest number of displaced people worldwide on record. A large these refugees are women, yet little is known about their specific situation and hurdles they have to face during journey. Herein, we investigated whether sociodemographic characteristics traumatic experiences in home country flight affected quality life refugee women arriving Germany 2015–2016. Six hundred sixty-three from six countries (Afghanistan, Syria, Iran, Iraq, Somalia, Eritrea) living...
Although sex differences are described in Coronavirus Disease 2019 (COVID-19) diagnoses and testing, many studies neglect possible gender-related influences. Additionally, research is often performed clinical populations, while most COVID-19 patients not hospitalized. Therefore, we investigated associations between variables, testing practices a large general population cohort during the first wave of pandemic when capacity was limited.