A5017873368- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Click Chemistry and Applications
- Fuel Cells and Related Materials
- Synthesis and Catalytic Reactions
- Surface Chemistry and Catalysis
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Antimicrobial Peptides and Activities
- Synthesis and Biological Evaluation
- Radiopharmaceutical Chemistry and Applications
- Carbon dioxide utilization in catalysis
- Peptidase Inhibition and Analysis
- Polymer Science and PVC
- Protein purification and stability
- Pharmacogenetics and Drug Metabolism
Monash University
2014-2023
John Wiley & Sons (United States)
2020
The University of Notre Dame Australia
2019
National Institutes of Health
2019
Australian Regenerative Medicine Institute
2013-2017
North Cumbria Integrated Care NHS Foundation Trust
2017
Yahoo (United Kingdom)
2013
Swansea University
2012
Organisation Mondiale de la Santé Animale
2011
Pfizer (France)
2011
We describe the fabrication and characterization of Near-Field Communication (NFC) devices based on highly flexible, carbon-based antennas composed stacked graphene multilayers. This material features a high value conductivity (4.20 * 105 S/m) comparable to monocrystalline graphite, but is much more flexible processable. first studied replacement metal with carbon using computer modeling, select best design. Then we manufactured several be used according communication protocol ISO/IEC 15693....
High conversion and selectivity can be obtained for the cross-metathesis of 2-butene with triglycerides unsaturated fatty acid esters derived from natural oils. This achieved remarkably high productive catalyst turnovers using second-generation ruthenium-based olefin metathesis catalysts.
The α-conotoxins are potent and selective antagonists of nicotinic acetylcholine receptors (nAChR). Exploitation these other peptides in research clinical settings has been hampered by the lability disulfide bridges that essential for toxin structure activity. One solution to this problem is replacement cystine with nonreducible dicarba linkages. We explore approach determining functional characteristics a analogue α-conotoxin α-ImI, (2,8)-dicarba-(3,12)-cystino α-ImI. was similar native...
Conotoxins have emerged as useful leads for the development of novel therapeutic analgesics. These peptides, isolated from marine molluscs genus Conus, evolved exquisite selectivity receptors and ion channels excitable tissue. One such peptide, α-conotoxin Vc1.1, is a 16-mer possessing an interlocked disulfide framework. Despite its emergence potent analgesic lead, molecular target mechanism action Vc1.1 not been elucidated to date. In this paper we describe regioselective synthesis dicarba...
α-Conotoxin RgIA is both an antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR) subtype and inhibitor high-voltage-activated N-type calcium channel currents. has therapeutic potential for treatment pain, but reduction disulfide bond framework under physiological conditions represents a liability clinical applications. We synthesized four analogues that replaced native pairs with nonreducible dicarba bridges. Solution structures were determined by NMR, activity assessed against...
A polyvinyl alcohol (PVA) fibrous carrier has been chemically modified for the immobilization of yeast dehydrogenase (ADH) with an aim to increase its stability over a wide pH range, prolong activity upon storage, and enhance reusability. The strategy involved functionalization chloropropinoyl chloride followed by amination ethylenediamine. Tethering ADH enzyme PVA scaffold was achieved glutaraldehyde. profile immobilized compared soluble as function pH, temperature on shifted optimal...
Abstract Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions resin‐attached peptides and technology is illustrated by highly selective synthesis dicarba analogues α‐conotoxin IMI. Copyright © 2007 European Peptide Society John Wiley & Sons, Ltd.
Replacement of disulfide bonds with non-reducible isosteres can be a useful means increasing the in vivo stability protein. We describe replacement A-chain intramolecular bond human relaxin-3 (H3 relaxin, INSL7), an insulin-like peptide that has potential applications treatment stress and obesity, physiologically stable dicarba bond. Solid phase synthesis was used to prepare analogue which two cysteine residues form were replaced allylglycine. On-resin microwave-mediated ring closing...
Acyclic diamines are valuable feedstocks for polyamide synthesis. Ruthenium-alkylidene catalysed cross metathesis of amino alkenes is problematic and acyl derivatisation can result in less efficient syntheses, poor catalyst turnover isomerisation. Temporary amine masking via stable soluble ammonium salts delivers cyclic acyclic aminoalkenes high yield purity.
ObjectivesThe third-generation cephalosporins recommended in national guidelines are amongst the last remaining effective agents for treatment of gonorrhoea. This study characterizes gonococcal isolates with decreased cefixime susceptibility from England and Wales.
Cross-metathesis of a wide range previously unreactive, sterically demanding alkenes can be achieved in fair to excellent yield using commercially available catalyst by facile strategy involving reversal steric preference.
A facile gram-scale preparation of a di-ammonium functionalised Ru-alkylidene complex which efficiently catalyses ring-closing metathesis and cross-metathesis reactions in water.
A comparative evaluation of the Crystal Enteric/Nonfermenter system (Crystal; Becton Dickinson, Cockeysville, Md.), API 20E (API; bioMérieux Vitek, Inc., Hazelwood, Mo.), and Vitek GNI card (Vitek; Vitek) was performed with 512 clinical isolates gram-negative bacilli, including 381 members family Enterobacteriaceae 131 nonenteric bacilli. With supplemental testing, API, Crystal, correctly identified to genus species level 505 (98.6%), 489 (95.5%), 494 (96.5%) isolates, respectively....
The cross-metathesis of synthetic and natural triglycerides containing unsaturated fatty acids with 2-butene can be achieved high conversion excellent productive turnovers. These reactions are catalysed by second-generation ruthenium-based olefin metathesis catalysts conducted at -5 degrees C in liquid 2-butene.
A method to facilitate regioselective formation of multiple dicarba isosteres cystine is described. sequence ruthenium-catalyzed cross metathesis and rhodium-catalyzed hydrogenation nonproteinaceous allylglycine derivatives has been developed achieve high-yielding unambiguous diaminosuberic acid derivatives. Allylglycine readily undergo yield in near quantitative yield. Under the same experimental conditions, prenylglycine was found be inert both Grubbs' Wilkinson's catalyzed hydrogenation,...
Bis-dicarba analogues of native dicystine-containing α-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis–hydrogenation strategy.
The effects of relative humidity on polymer photodegradation have been studied using a closed loop photoreactor which allows measurements evolved CO2. Two different polymers were expected to responses studied; PVC and polyethylene, both containing photoactive TiO2 pigment. Relative was controlled in the by means salt solutions bypass control. With polymers, there an initial CO2 evolution rate less dependent humidity. After short incubation time, changed higher secondary more sensitive For...
The structural transitions required for insulin to activate its receptor and initiate regulation of glucose homeostasis are only partly understood. Here, using ring-closing metathesis, we substitute the A6-A11 disulfide bond with a rigid, non-reducible dicarba linkage, yielding two distinct stereo-isomers (cis trans). Remarkably, cis isomer displays full potency, rapidly lowering blood in mice (even under insulin-resistant conditions). It also posseses reduced mitogenic activity vitro....