A5071875830- Delphi Technique in Research
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Child and Adolescent Psychosocial and Emotional Development
- Obstructive Sleep Apnea Research
- Clinical practice guidelines implementation
- Neonatal Respiratory Health Research
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Early Childhood Education and Development
- Ethics in Clinical Research
- Health Sciences Research and Education
- Gastroesophageal reflux and treatments
- Adolescent and Pediatric Healthcare
- Statistical Methods in Clinical Trials
- Child Nutrition and Feeding Issues
- Health and Medical Research Impacts
- Economic and Financial Impacts of Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cerebral Palsy and Movement Disorders
Hospital for Sick Children
2018-2023
SickKids Foundation
2018-2023
Institute for Clinical Evaluative Sciences
2018-2023
Children's Hospital of Eastern Ontario
2015-2022
Great Ormond Street Hospital
2019-2020
University College London
2019-2020
Centre for Addiction and Mental Health
2020
University of Toronto
2020
Rationale: Lung volume recruitment therapy slows rate of decline lung function in neuromuscular disease, possibly due to enhanced airway clearance, reduced atelectasis, or prevention chest wall contractures.Objectives: To determine if maintains maximal insufflation capacity (MIC), despite VC.Methods: This was a retrospective cohort study (1991–2008) individuals with Duchenne muscular dystrophy at pediatric and adult tertiary centers. prescribed twice daily, according protocol. Changes over...
Study Objectives: Obstructive sleep apnea (OSA) is commonly treated with adenotonsillectomy (AT), bringing risk of perioperative respiratory adverse events (PRAEs).We aimed to concurrently identify clinical and polysomnographic predictors PRAEs in children undergoing AT.Methods: Retrospective study AT at a tertiary-care pediatric hospital, prior in-hospital polysomnography, January 2010 December 2016.PRAEs included those requiring oxygen, jaw thrust, positive airway pressure, or mechanical...
Inadequate and poor quality outcome reporting in clinical trials is a well-documented problem that impedes the ability of researchers to evaluate, replicate, synthesize, build upon study findings impacts evidence-based decision-making by patients, clinicians, policy-makers. To facilitate harmonized transparent outcomes trial protocols published reports, Instrument for Planned Endpoints Clinical Trials (InsPECT) being developed. The final product will provide unique InsPECT extensions SPIRIT...
Sleep-disordered breathing (SDB) is common in children with Down syndrome, but the trajectory and long-term outcomes are not well-described. In a retrospective longitudinal cohort of study objectives were to (1) characterize polysomnography (PSG), treatments received, persistence/recurrence SDB (2) explore predictors persistence/recurrence.A was conducted who underwent PSGs between 2004 2014. defined as obstructive sleep apnea (OSA)-mixed (apnea-hypopnea index [AHI] >5 events/hour), central...
Abstract Background Evidence-based health care is informed by results of randomized clinical trials (RCTs) and their syntheses in meta-analyses. When the trial outcomes measured are not clearly described publications, knowledge synthesis, translation, decision-making may be impeded. While heterogeneity adolescent major depressive disorder (MDD) RCTs has been described, comprehensiveness outcome reporting unknown. This study aimed to assess primary evaluating treatments for MDD. Methods...
OBJECTIVES Clear outcome reporting in clinical trials facilitates accurate interpretation and application of findings improves evidence-informed decision-making. Standardized core outcomes for neonatal have been developed, but little is known about how primary are reported trials. Our aim was to identify strengths weaknesses recent METHODS Neonatal including ≥100 participants/arm published between 2015 2020 with at least 1 from a set were eligible. Raters recruited Cochrane trained evaluate...
Obstructive sleep-disordered breathing is commonly treated with adenotonsillectomy. Our study objective was to describe perioperative opioid dosing in children a range of medical complexity evaluated for obstructive undergoing adenotonsillectomy and investigate its association postoperative respiratory adverse events (PRAEs).A retrospective chart review who underwent had preoperative polysomnography performed conducted. PRAEs included requiring oxygen, jaw thrust, positive airway pressure,...
Patients, families and clinicians rely on published research to help inform treatment decisions. Without complete reporting of the outcomes studied, evidence-based clinical policy decisions are limited researchers cannot synthesise, replicate or build existing findings. To facilitate harmonised in trial protocols reports, Instrument for Planned Endpoints Clinical Trials (InsPECT) is under development. As one initial steps development InsPECT, a scoping review will identify synthesise...
Introduction Major depressive disorder (MDD) is a common mental health condition in adolescents. Randomised clinical trials (RCTs) are the gold standard for assessing safety and efficacy of interventions this population. Heterogeneity outcomes measured reported between RCTs limits ability to compare, contrast, combine trial results clinically meaningful way. There currently no core outcome set (COS) available use evaluating adolescents with MDD. We will conduct systematic scoping review...
Background: Inadequate and poor quality outcome reporting in clinical trials is a well-documented problem that impedes the ability of researchers to evaluate, replicate, synthesize build upon study findings impacts evidence-based decision making by patients, clinicians, policy makers. To facilitate harmonized transparent outcomes trial protocols published reports, Instrument for Planned Endpoints Clinical Trials (InsPECT), being developed. The final product will provide unique InsPECT...
Dissemination of research results is a key component the continuum and commonly achieved through publication in peer-reviewed academic journals. However, issues poor quality reporting literature are well documented. A lack formal training journalology (i.e., science) may contribute to this problem. To help address gap training, Enhancing QUAlity Transparency Of health Research (EQUATOR) Canada Publication School was developed facilitated by internationally-renowned faculty train researchers...