A5056527532- Dialysis and Renal Disease Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Renal Diseases and Glomerulopathies
- COVID-19 Impact on Reproduction
- Renal Transplantation Outcomes and Treatments
- Body Composition Measurement Techniques
- Magnesium in Health and Disease
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Chemotherapy-induced organ toxicity mitigation
- Hemodynamic Monitoring and Therapy
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Organ Donation and Transplantation
- Peripheral Artery Disease Management
- Diabetic Foot Ulcer Assessment and Management
- Advanced Glycation End Products research
- Mycobacterium research and diagnosis
- Vaccine Coverage and Hesitancy
- Lysosomal Storage Disorders Research
- Psoriasis: Treatment and Pathogenesis
- COVID-19 epidemiological studies
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
Mahidol University
2015-2024
Ramathibodi Hospital
2015-2024
Bhumibol Adulyadej Hospital
2020
The Royal Free Hospital
2014-2018
University College London
2014-2018
Roland Hill (United Kingdom)
2018
Although there have been many advancements in the treatment of patients with chronic kidney disease (CKD) over last 50 years, terms reducing cardiovascular risk, mortality remains unacceptably high, particularly for those who progress to stage 5 CKD and initiate dialysis (CKD5d). As risk increases exponentially progressive stage, question arises as whether preservation residual renal function once has initiated can reduce risk. Observational studies date reported an association between even...
Abstract Background Marked hyperphosphatemia, hyperparathyroidism and 25-hydroxyvitamin D deficiency are associated with mortality in dialysis patients. Such data chronic kidney disease stage 2–4 population limited. It has been suggested that high-normal serum phosphate predicts worse renal patient outcomes. The regarding parathyroid hormone outcomes this is present study examined mineral metabolism its association the development of end-stage Methods This a prospective cohort included 466...
The degree of tubular atrophy and interstitial fibrosis (IFTA) is an important prognostic factor in glomerulonephritis. Imbalance between pro-inflammatory cytokines such as monocyte chemoattractant protein- 1 (MCP-1) protective epidermal growth (EGF) likely determine IFTA severity. In separate studies, elevated MCP-1 decreased EGF have been shown to be associated with this study, we aim evaluate the predictive value urinary EGF/MCP-1 ratio compared each biomarker individually for moderate...
Immunogenicity following inactivated SARS-CoV-2 vaccination among solid organ transplant recipients has not been assessed. Seventy-five patients (37 kidney [KT] and 38 healthy controls) received two doses, at 4-week intervals, of an whole-virus vaccine. SARS-CoV-2-specific humoral (HMI) cell-mediated immunity (CMI) were measured before, 4 weeks post-first dose, 2 post-second dose. The median (IQR) age KT was 50 (42-54) years 89% receiving calcineurin inhibitors/mycophenolate/corticosteroid...
Abstract Vaccination with inactivated SARS-CoV-2 virus produces suboptimal immune responses among kidney transplant (KT), peritoneal dialyzed (PD), and hemodialyzed (HD) patients. Participants were vaccinated two-dose vaccine (V2) a third dose of ChAdOx1 nCoV-19 (V3) at 1–2 months after V2. We enrolled 106 participants: 31 KT, 28 PD, HD patients 16 controls. Among groups, median (IQR) anti-receptor binding domain antibody levels 1.0 (0.4–26.8), 1092.5 (606.9–1927.2), 1740.9 (1106–3762.3)...
Background Metformin-associated lactic acidosis (MALA) is a rare event but underrecognition may lead to unfavorable outcomes in type 2 diabetes patients. While many risk factors of MALA have been identified, how reduce mortality from matter debate. This study aimed explore the associated with 30-day amongst Methods An observational enrolled patients diagnosed between January 2014 and December 2017. was defined by history metformin administration, metabolic (arterial blood gas pH <7.35 or...
<b><i>Introduction:</i></b> Increased natriuretic peptides are associated with increased cardiovascular and all-cause mortality for haemodialysis (HD) patients. However, debate continues whether these biomarkers by extracellular water (ECW) excess can be used to aid clinical assessment of volume status help determine target weight. <b><i>Methods:</i></b> We measured N terminal probrain peptide (NT-proBNP) predialysis in 375 stable outpatients...
Haemodialysis (HD) patients have an increased risk of cardiovascular death. In addition to the standard disease (CVD) factors, HD additional factors including bone mineral disorders, anaemia and uraemic toxins, advance glycosylation end product (AGEs). AGEs increase in due reduced renal clearance production. Tissue measured by skin autofluorescence (SAF) been shown be more reliable reproducible asses AGE accumulation compared with serum levels. We wished determine whether increasing SAF was...
•The magnesium preloading regimen tend to lower incidence of cisplatin-associated acute kidney injury (cis-AKI).•The effects cisplatin on function were mainly subacute, thus clinicians should carefully monitor not only for cis-AKI but also cis-AKD. BackgroundCisplatin is one the most potent chemotherapeutic drugs used in head and neck cancer treatment; however, nephrotoxicity major side-effect limiting usage. Magnesium supplementation has been reported reduce risk non-controlled studies. We...
CVD remains the major cause of death for dialysis patients. Dialysis patients have both traditional and nontraditional risk factors, including retention advanced glycation end products (AGE). Tissue AGE can be measured by skin autofluorescence (SAF) are a reliable measurement chronic exposure. Dietary intake may lower in vegetarian than non-vegetarian patients, so we determined whether had SAF We 332 adult haemodialysis using UV technique standardised manner. Information about patients'...
Background On-line hemodiafiltration (HDF) clears more azotemic toxins compared to high-flux hemodialysis (HD). The response vaccination is impaired in dialysis patients. We wished determine whether the immune responses influenza vaccine patients treated by HDF were stronger than those HD. Materials and methods conducted a prospective cohort study chronic during 2016 2017 seasons. All participants received single standard dose of trivalent vaccine, we studied elicited humoral...
The aim of this study was to evaluate the impact a hospital protocol in response patient deterioration general wards, stratified using national early warning score (NEWS), on primary outcomes in-hospital mortality and percentage patients transferred intensive care unit (ICU).We conducted prospective observational cohort among adult medical admitted university Bangkok. A 4-month pre-protocol period (November 2015 February 2016) assigned control group (March 2016 June allocated group. On...
Introduction There is a need for sensitive and specific biomarkers to predict kidney damage therapeutic response in lupus nephritis (LN). Monocyte chemoattractant protein-1 (MCP-1) epidermal growth factor (EGF) are cytokines with divergent roles. EGF or EGF/MCP1 ratio have been shown correlate prognosis primary glomerulonephritis, but there limited information This study evaluated the roles of MCP-1, their as histopathology treatment LN. Methods was cross-sectional observational study....
Immunogenicity following an additional dose of Coronavirus disease 2019 (COVID-19) vaccine was investigated in extended primary series among kidney transplant (KT) recipients. Eighty-five KT participants were randomized to receive either mRNA (M group; <i>n</i> = 43) or viral vector (V 42) vaccine. Among them, 62% male, with a median (IQR) age 50 (43–59) years and post-transplantation duration 46 (26–82) months. At 2 weeks post-additional dose, there no difference the seroconversion rate...
Patients with end-stage kidney disease (ESKD) are at risk of severe coronavirus and mortality. Immunogenicity acute respiratory syndrome 2 (SARS-CoV-2) inactivated whole-virus vaccine in patients ESKD has never been explored.We conducted a prospective cohort study 60 30 healthy controls. All participants received two doses an SARS-CoV-2 (Sinovac Biotech Ltd) 4 weeks apart. SARS-CoV-2-specific humoral cell-mediated immune responses were investigated referenced controls.After doses,...
Increasing urea clearance by hemodialysis (HD) has not improved patient survival. Hemodiafiltration (HDF) been reported to reduce cardiovascular mortality. HDF increases middle sized solute clearances. Advanced glycosylation end products (AGEs) are associated with increased We wished determine whether reduces AGEs. Skin auto-fluorescence (SAF) measures circulating AGEs deposited in the skin. compared SAF measurements 12 months apart high flux HD and patients. At enrollment was different (HD...
The durability of a three-dose extended primary series COVID-19 vaccine in dialysis patients remains unknown. Here, we assessed dynamic changes SARS-CoV-2-specific humoral and cell-mediated immunity at baseline, 3 months, 6 months after the 29 hemodialyzed (HD), 28 peritoneal dialyzed (PD) patients, 14 healthy controls. Participants received two doses inactivated SARS-CoV-2 followed by dose ChAdOx1 nCoV-19 vaccine. At median anti-RBD IgG titers (IQR) significantly declined from baseline HD...