A5044109342- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Fibroblast Growth Factor Research
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Nanoparticle-Based Drug Delivery
- Telomeres, Telomerase, and Senescence
- Skin and Cellular Biology Research
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Wnt/β-catenin signaling in development and cancer
- Connective tissue disorders research
- Cancer Cells and Metastasis
- Carbohydrate Chemistry and Synthesis
- Bone health and treatments
- Nitric Oxide and Endothelin Effects
- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Chemotherapy-induced cardiotoxicity and mitigation
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- Cardiovascular Function and Risk Factors
- Nanoparticles: synthesis and applications
- Birth, Development, and Health
- RNA Interference and Gene Delivery
University of Crete
2016-2025
Crete University Press
2023
University of Patras
2022
Zero to Three
2011
University Hospital of Heraklion
2002-2009
Karolinska Institutet
1996-1998
The present study focused on the elucidation of putative anticancer potential quercetin. activity quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay 9 tumor cell lines (colon carcinoma CT‑26 cells, prostate adenocarcinoma LNCaP human PC3 pheocromocytoma PC12 estrogen receptor‑positive breast cancer MCF‑7 acute lymphoblastic leukemia MOLT‑4 T‑cells, myeloma U266B1 lymphoid Raji cells ovarian CHO cells). Quercetin found to induce apoptosis all tested utilized...
In activated human neutrophils a burst of nitric oxide (NO) converts intracellular GSH to S-nitrosoglutathione (GSNO) which is subsequently cleaved restore by an unknown mechanism. We discovered that GSNO NADPH oxidizing substrate for or calf thymus thioredoxin reductase (TR) with apparent Km value 60 µM and Kcat 0.6 × s−1. Addition (Trx) stimulated the initial oxidation rate severalfold but was accompanied progressive inactivation TR. Escherichia coli TR lacked activity GSNO, E. Trx...
Hyaluronan (HA) modulates key cancer cell functions through interaction with its CD44 and receptor for hyaluronic acid-mediated motility (RHAMM) receptors. HA was recently found to regulate the migration of fibrosarcoma cells in a manner specifically dependent on size. Here, we investigated effect HA/RHAMM signaling ability HT1080 adhere onto fibronectin. Low molecular weight (LMWHA) significantly increased (p ≤ 0.01) adhesion capacity cells, which high inhibited. The RHAMM-deficient but not...