A5002805618- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
- Metabolism, Diabetes, and Cancer
- Neurological diseases and metabolism
- Ion Channels and Receptors
- Diabetes Management and Research
- Mesenchymal stem cell research
- Diabetes and associated disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Neurogenetic and Muscular Disorders Research
- Adipose Tissue and Metabolism
- Neurological Disorders and Treatments
- Prenatal Substance Exposure Effects
- Connexins and lens biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Medical Research and Treatments
- Neuroscience and Neural Engineering
- Congenital heart defects research
- Plant Reproductive Biology
- Postharvest Quality and Shelf Life Management
- Cerebrovascular and genetic disorders
- Autism Spectrum Disorder Research
- Tissue Engineering and Regenerative Medicine
Tata Institute of Fundamental Research
2018-2025
National Centre for Biological Sciences
2017-2025
Manipal Academy of Higher Education
2011-2015
Monash University Malaysia
2011-2013
Institute for Stem Cell Biology and Regenerative Medicine
2013
Guanine nucleotide binding protein (G-protein)-coupled receptors (GPCRs) are eukaryotic transmembrane proteins found in all living organisms. Their versatility and roles several physiological processes make them the single largest family of drug targets. Comparative genomic studies using various model organisms have provided useful information about target receptors. The similarity genetic makeup teleosts to that humans other vertebrates aligns with study GPCRs. Gonadotropin-releasing...
ABSTRACT Parkinson's disease (PD) has emerged as a multisystem disorder affecting multiple cellular and organellar systems in addition to the dopaminergic neurons. Disease‐specific induced pluripotent stem cells (iPSCs) model early developmental changes perturbations that are otherwise inaccessible from clinical settings. Here, we report patient‐derived iPSCs carrying homozygous recessive mutation, R741Q, PLA2G6 gene. A gene‐edited R747W iPSC line mirrored these phenotypes, thus validating...
It is well established that fibroblasts and mesenchymal stem cells ( MSC ) share several characteristics with subtle differences. However, no study highlighting the versatility of beyond their multipotentiality has been reported so far. Mouse embryonic MEFs are widely used as feeder layers to support growth ESC ). We hypothesized MEF may retain ES ‐like features in concurrence developmental hierarchy addition multipotent nature. Hence, we performed a comparative assessment determine ability...
Insufficient β-cell mass is a common denominator for both type 1 and 2 diabetes. In vitro generation of β-cells from islet precursor cells, exocrine cells or ductal epithelia provide an alternative source insulin-producing cells. However the presence multipotent within pancreas also deliberated. this study we isolated mesenchymal stromal cell (MSC)-like adult mouse by collagenase digestion. We used Knockout DMEM our isolation procedure floating islets acini were removed after 48 h. This...
Ca2+ signaling plays a significant role in the development of vertebrate nervous system where it regulates neurite growth as well synapse and neurotransmitter specification. Elucidating mammalian neuronal has been largely restricted to either small animal models or primary cultures. Here we derived human neural precursor cells (NPCs) from embryonic stem understand functional significance less understood arm calcium signaling, Store-operated entry SOCE, development. Human NPCs exhibited...
Aim . Stem cell therapy is one of the upcoming therapies for treatment diabetes. Discovery potent differentiating agents a prerequisite increasing islet mass. The present study an attempt to screen potential novel small biomolecules their property into pancreatic cells using NIH3T3, as representative extra stem cells/progenitors. Methods To identify new that stimulate differentiation, we screened various compounds isolated from Enicostemma littorale NIH3T3 and morphological changes were...
Gestational alcohol exposure causes a range of neuropsychological disorders by modulating neurodevelopmental genes and proteins. The extent damage depends on the stage embryo as well dosage, duration frequency exposure. Here, we investigated neurotoxic effects using human embryonic stem cells. Multiple read-outs were engaged to assess proliferation differentiation capacity neural precursor cells upon 100 mM ethanol for 48 h corresponding blood levels binge drinkers. Whole-genome analysis...
Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent phospholipase enzyme and is associated with young-onset autosomal recessive Parkinson's disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from patient PD carrying homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) unaffected heterozygous parent (NCBSi004-A). These iPSC will be used for investigating the key molecular signatures of (YOPD), to understand predictive...