A5066604832- Mechanical Circulatory Support Devices
- Cancer Immunotherapy and Biomarkers
- Vascular anomalies and interventions
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Caveolin-1 and cellular processes
- Chemotherapy-induced cardiotoxicity and mitigation
- Lipid metabolism and disorders
- Cardiomyopathy and Myosin Studies
- Metabolism and Genetic Disorders
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Gastrointestinal disorders and treatments
- Coenzyme Q10 studies and effects
- Sarcoidosis and Beryllium Toxicity Research
- Immune Cell Function and Interaction
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Cardiovascular and Diving-Related Complications
MaineHealth
2024
Maine Medical Center
2017-2023
Maine Medical Center
2020-2022
Bowdoin College
2013
We report three patients who presented with chest pain after receiving either the BNT162b2 Pfizer/BioNTech or mRNA-1273 Moderna/NIH vaccine. Clinical presentation, biomarker, and cardiac MRI supported myocarditis. It is imperative that potential side effects of COVID-19 vaccine are reported to improve our knowledge about mRNA vaccines.
Neuropeptides are the largest class of signaling molecules used by nervous systems. Today, neuropeptide discovery commonly involves chemical extraction from a tissue source followed mass spectrometric characterization. Ideally, procedure accurately preserves sequence and any inherent modifications native peptides. Here, we present data showing that this is not always true. Specifically, evidence that, in lobster Homarus americanus, orcokinin family members, NFDEIDRSGFG-OMe SSEDMDRLGFG-OMe,...
Immune checkpoint inhibitors (ICIs) are a major advance in oncology and have become first- or second-line therapy for over 50% of patients. ICI-associated myocarditis is complication that, although rare, has high mortality rate. We present case presenting as complete heart block. Traditional treatment with high-dose steroids was abandoned this case, owing to steroid-induced psychosis. Alternative immunomodulators initiated good response. This highlights the variable presentation myocarditis....
Importance: Immune checkpoint inhibitors (ICIs) are a class of immunotherapies that have significant clinical efficacy in treating many cancer types, but they also associated with systemic effects, including myocarditis.
Introduction: The coronary sinus is responsible for venous drainage of the heart. Congenital anomalies are rare and typically associated with other anomalies, such as atrial septal defects or congenital heart malformations.
Case Presentation: A 70 year old female with a past medical history significant for end stage renal disease secondary to polycystic kidney status post failed transplant now on peritoneal dialysis presented the emergency department hypotension after three days of nausea, vomiting and diarrhea at home. She was started intravenous fluids improvement in her blood pressure. Peritoneal fluid analysis showed no suggestion peritonitis. Given presentation, gastrointestinal illness suspected. Stool...
Case Presentation: A 6 year old male with a past medical history of appendicitis presented to the emergency department cramping, intermittent, severe periumbilical abdominal pain. One week prior admission he had two evaluations for similar pain and was diagnosed constipation. On day his increased in severity prompting re-evaluation. In ED an elevated lipase (132 U/L), leukocytosis (33 thou/uL) triglycerides (588mg/dL) after period 6-8 hours poor oral intake. …
Ventricular assist device (VAD) pump thrombosis is a known complication and while the preferred standard treatment surgical exchange this procedure not without risk for some patients risks are prohibitive. This case of 68-year-old female with bilateral HeartWare ventricular devices (HVAD) implanted as destination therapy who presented signs recurrent thrombosis. Surgical was deemed to confer prohibitive due her underlying medical co-morbidities therefore an option treatment. After careful...