A5030044168- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Medical Imaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Nuclear Structure and Function
- Inflammatory mediators and NSAID effects
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Folate and B Vitamins Research
- Radiomics and Machine Learning in Medical Imaging
Istanbul Aydın University
2024
Kitasato University
2021
University of Tsukuba
2016-2021
Turgut Özal University
2015-2017
Ankara University
2016
Nuclear-cytoplasmic transport through nuclear pore complexes is mediated by receptors. Previous reports have suggested that aberrant nuclear-cytoplasmic due to mutations or overexpression of and receptors closely linked diseases. Nup214, a component complexes, has been found as chimeric fusion proteins in leukemia. Among various Nup214 proteins, SET-Nup214 DEK-Nup214 shown be engaged tumorigenesis, but their oncogenic mechanisms remain unclear. In this study, we examined the functions...
Abstract Background Lung cancer is the leading cause of cancer-related deaths worldwide. The combination fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) and computed (CT) has a major impact on diagnosis, staging, treatment planning follow-up lung patients. maximum standardized uptake value (SUVmax) an easily performed most widely used semi-quantitative index for analysis FDG PET images estimation metabolic activity. This study aimed to investigate role PET/CT in...
Background Genetic factors play a large role in cancer, and thus, there is great desire to understand the effects of different genes cancer also develop gene therapy for better treatments. Therefore, development alternative diagnosis modalities utmost importance. The aim our study was illuminate ESM 1 (endothelial cell‐specific molecule‐1, known as Endocan) proliferation migration head neck thus helping pave way new treatment predictive biomarkers. Methods expression shown with...
SET-Nup214 is a recurrent fusion gene that mainly observed in T-cell acute lymphoblastic leukemia (T-ALL). Dysregulation of homeobox (Hox) genes frequently patients with leukemia. Consistent this, HoxA are upregulated the + T-ALL cell line and patients. Although has been reported to be recruited promoter regions genes, detailed mechanisms how specifically binds promoters regulates expression not known. In this study, we demonstrated interacts MLL via SET acidic region SET-Nup214....
By investigating the MACC1 gene (metastasis-associated in colon cancer 1) stem cells (CSC) resistant to chemotherapy and (CS) sensitive we determineda steady expression both types of head neck cancer. In conformity with result examined if this could be a competitor for chemotherapy. According literature, shows clear [1]. Here CSC investigated it as possible biomarker.Our experiments were performed UT -SCC -74 primary cell line. We MACC -1 by Real Time PCR from isolated CS.Expression showed...
MYC is a transcription factor coding gene that believed to control 15% of the genes in entire human genome. The central role c-MYC cancer pathogenesis makes it major therapeutic target field anticancer agent development.We targeted acetyl-lysine binding modules or bromodomains, which are associated with transcriptional activation.Sequence specific inhibition BET bromodomains small hairpin RNAs (shRNAs) resulted cessation cellular proliferation different cell lines. Unlike previous studies on...
Abstract Boric acid is a very common chemical used in wide variety of applications as well medicine. In this study, the usage boric potential alternative cancer therapeutic was investigated by examining its effect head and neck cell line proliferation tumor suppressor gene expression. Head lines UT-SCC 6A, 6B, 9A, 16A, 16B, 24A, 54C, 74A, 74B were treated with varying doses acid, ranging from 200 ug/mL to 1800 XTT assay measure dose response. Subsequently, RNA isolated cells converted cDNA...
Abstract Cancer stem cells (CSC) are thought to be a sub-population of cancer cells, which the main tumorigenic in tumors. Although chemoradiotherapy may kill majority rapidly dividing CSC-like cell populations left behind due their low turnover and infrequent cycling. In 2007, Prince et al. reported presence head neck for first time. current study, UTTSCC74A UTTSCC74B lines as material derived from primary tumor lymph node metastasis, respectively, were used. FACS was used isolation using...