A5073711971- Mental Health Treatment and Access
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Adolescent and Pediatric Healthcare
- Digital Mental Health Interventions
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Sleep and related disorders
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Treatment of Major Depression
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Suicide and Self-Harm Studies
- Mental Health and Patient Involvement
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Mobile Health and mHealth Applications
- Health disparities and outcomes
- Health, psychology, and well-being
- Telemedicine and Telehealth Implementation
- Transcranial Magnetic Stimulation Studies
- Primary Care and Health Outcomes
The University of Sydney
2016-2025
Max Planck Florida Institute for Neuroscience
2025
University of California, Davis
2025
The University of Notre Dame Australia
2015-2024
Indiana University School of Medicine
2024
University of Notre Dame
2013-2024
St Vincent's Hospital Sydney
2024
Indiana University
2024
St Vincent’s Private Hospital Sydney
2015-2023
South Carolina Department of Natural Resources
2023
Background Hippocampal volume reduction has been reported inconsistently in people with major depression. Aims To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular genetic risk factors. Method Totals of 66 depression 20 control participants underwent magnetic resonance imaging clinical assessment. Measures severity, psychomotor retardation, verbal visual specific factors were collected. Results Reduced volumes occurred older depression, those both...
Recognizing that current frameworks for classification and treatment in psychiatry are inadequate, particularly use young people early intervention services, transdiagnostic clinical staging models have gained prominence. These aim to identify where individuals lie along a continuum of illness, improve selection better understand patterns illness continuity, discontinuity aetiopathogenesis. All these factors relevant help‐seeking mental health needs experienced during the peak age range...
Mood and psychotic syndromes most often emerge during adolescence young adulthood, a period characterised by major physical social change. Consequently, the effects of adolescent-onset mood can have long term consequences. A key clinical challenge for youth mental health is to develop test new systems that align with current evidence comorbid presentations underlying neurobiology, are useful predicting outcomes guiding decisions regarding provision appropriate effective care. Our highly...
The large contribution of psychiatric disorders to premature death and persistent disability among young people means that earlier identification enhanced long-term care for those who are most at risk developing life-threatening or chronic is critical. Clinical staging as an adjunct diagnosis address emerging has been proposed presenting care; however, the longer-term utility this system not established.To determine rates transition from later stages anxiety, mood, psychotic, comorbid...
Objective: To develop and validate a self-report screening tool for common mental disorders. Design setting: Sequential development validation studies in three cohorts of patients general practice one cohort specialist psychiatry clinic. Participants: 1585 examined cross-sectionally longitudinally; 46515 attending 386 practitioners nationwide; 364 participating longitudinal study psychiatric disorders practice; 522 Main outcome measures: Performance the 12 items from 34-item SPHERE...
Abstract Aim: The study aims to apply clinical staging young people who present for mental health care; describe the demographic features, patterns of psychological symptoms, disability correlates and stages those people; report longitudinal estimates progression from less more severe stages. Methods: uses cross‐sectional assessments managed in specialized youth clinics. On basis records, subjects were assigned a specific ‘stage’ (i.e. ‘help‐seeking’, ‘attenuated syndrome’, ‘discrete...
Objective: To assess the extent to which youth-specific, mental health care centres engage young people (12–25 years of age) in treatment, and report degree psychological distress, diagnostic type, stage illness, psychosocial vocational impairment evident these people. Design setting: Standardised clinical self-report assessments consecutive presentations at two youth-specific from October 2007 December 2009. Both sites are operated by Brain Mind Research Institute Sydney, Australia, as part...
Clinical psychiatry has always been limited by the lack of objective tests to substantiate diagnoses and a specific treatments that target underlying pathophysiology. One area in which these twin failures most frustrating is major depression. Due very considerable progress basic clinical neurosciences sleep-wake cycles circadian systems this situation now rapidly changing.
Purpose Prolonged and disabling fatigue is prevalent after cancer treatment, but the early natural history of cancer-related (CRF) has not been systematically examined to document consistent presence symptoms. Hence, relationships cancer, surgery, adjuvant therapy are unclear. Patients Methods A prospective cohort study women receiving treatment for early-stage breast was conducted. Women (n = 218) were enrolled surgery observed at end 1, 3, 6, 9, 12 months as well 5 years. Structured...
Abstract This study evaluated the potential of circadian measures as early markers mood disorders subtypes. Patients with bipolar had significantly lower levels and later onset melatonin secretion than those unipolar depression. Furthermore, abnormal phase angles between sleep, temperature were found in several patients.
Abstract Functional disability is the lead contributor to burden of mental illness. Cognitive deficits frequently limit functional recovery, although whether changes in cognition and are longitudinally associated recent-onset individuals remains unclear. Using a prospective, cohort design, 311 patients were recruited assessed at baseline. One hundred sixty-seven met eligibility criteria (M=21.5 years old, s.d.=4.8) returned for follow-up (M=20.6 months later, s.d.=7.8). Two-hundred thirty...
Social-cognitive deficits contribute to poor functional outcomes in early psychosis; however, no effective pharmacological treatments exist for these problems. This study was the first investigate efficacy of an extended treatment oxytocin nasal spray combined with social cognition training (SCT) improve cognition, clinical symptoms, and functioning psychosis. In a double-blind, randomized, placebo-controlled, between-subjects trial, 52 individuals (aged 16–35 years) diagnosed psychosis...
Background Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young early-course outpatients, the aim of identifying cognitive markers that predict later socio-occupational functioning. Methods At baseline, 183 outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD 4.5) an average re-assessment interval months (SD 7.0), primary...
<h3>Background:</h3> The nature of sleep-wake abnormalities in individuals with mental disorders remains unclear. present study aimed to examine the differences objective ambulatory measures and activity cycles across young people anxiety, mood or psychotic disorders. <h3>Methods:</h3> Participants underwent several days actigraphy monitoring. We divided participants into 5 groups (control, anxiety disorder, unipolar depression, bipolar disorder) according primary diagnosis....
Mental disorders that commonly emerge during adolescence and young adulthood are associated with substantial immediate burden risks, as well potentially imparting lifetime morbidity premature mortality. While the development of health services youth focused prioritize early intervention has been a critical step forward, an ongoing challenge is heterogeneous nature symptom profiles illness trajectories. Consequently, it often difficult to provide quality mental care, at scale, addresses broad...
Youth with mental health problems often have difficulties engaging in education and employment. In Australia, youth services been widely established a key aim of improving role functioning; however, there is little knowledge those who are not engaged employment, or training (NEET) the factors which may influence this. This study aimed to examine NEET status its correlates sample such youth.Cross-sectional data from longitudinal cohort study.Between January 2011 August 2012, young people...
Background The Mental Health eClinic (MHeC) aims to deliver best-practice clinical services young people experiencing mental health problems by making care accessible, affordable, and available whenever wherever they need it most. original MHeC consists of home page with a visible triage system for those requiring urgent help; online physical self-report assessment; results dashboard; booking videoconferencing system; the generation personalized well-being plan. Populations who do not speak...
Background: Each year, many young Australians aged between 16 and 25 years experience a mental health disorder, yet only small proportion access services even fewer receive timely evidence-based treatments. Today, with ever-increasing to the Internet use of technology, potential provide all people (24 hours day, 7 days week) support they require improve their well-being is promising. Objective: The aim this study was participatory design (PD) as research methodologies end users (young youth...