A5067991227- Sirtuins and Resveratrol in Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Calcium signaling and nucleotide metabolism
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Fungal and yeast genetics research
- Genetic diversity and population structure
- Rice Cultivation and Yield Improvement
- Mitochondrial Function and Pathology
- Infant Nutrition and Health
- Plant Pathogens and Fungal Diseases
- Smart Agriculture and AI
- Phytoestrogen effects and research
- Plant and animal studies
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease Diagnosis and Treatment
- Biological and pharmacological studies of plants
- Plant Gene Expression Analysis
- Milk Quality and Mastitis in Dairy Cows
- Spectroscopy and Chemometric Analyses
- Agricultural pest management studies
- Nutrition, Genetics, and Disease
University of California, Davis
2005-2023
National Pingtung University of Science and Technology
2014-2021
China Agricultural University
2010-2012
Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between pathway has been reported. Here we investigate such mammals. We show Sirt1 positively regulates insulin secretion pancreatic beta cells. represses uncoupling protein (UCP) gene UCP2 by binding directly to promoter. cell lines which is reduced SiRNA, levels elevated blunted. The up-regulation of associated with failure cells increase ATP after...
Summary Antioxidant activity of whey protein concentrate (WPC) hydrolysates was evaluated. Hydrolysates were obtained by pepsin, trypsin, alcalase and flavourzyme enzymatic reaction preheat treatment 95 °C for 5 or 10 min. The degree hydrolysis (DH) determined 2,4,6‐trinitrobenzene sulphonic acid method, antioxidant properties three spectrophotometric methods: ferricyanide ferric reducing/antioxidant power assay diphenyl‐picryl hydrazinyl radical‐scavenging activity. For all the enzymes,...
This study aimed to establish a machine learning (ML)-based rice blast predicting model decrease the appreciable losses based on short-term environment data. The average, highest and lowest air temperature, average relative humidity, soil temperature solar energy were selected for development. developed multilayer perceptron (MLP), support vector (SVM), Elman recurrent neural network (Elman RNN) probabilistic (PNN) evaluated by F-measures. Finally, sensitivity analysis (SA) was conducted...
Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite participating in cellular redox chemistry and signaling, the complex regulation of NAD+ metabolism not yet fully understood. To investigate this, we established a NAD+-intermediate specific reporter system to identify factors required for salvage metabolically linked nicotinamide (NAM) nicotinic acid (NA). Mutants lacking components NatB complex, NAT3 MDM20, appeared as hits this screen. Nα-terminal acetyltransferase...
NADH (NAD+) is an essential metabolite involved in various cellular biochemical processes. The regulation of NAD+ metabolism incompletely understood. Here, using budding yeast (Saccharomyces cerevisiae), we established intermediate-specific genetic system to identify factors that regulate the de novo branch biosynthesis. We found a mutant strain (mac1Δ) lacking Mac1, copper-sensing transcription factor activates copper transport genes during deprivation, exhibits increases quinolinic acid...
Until the late 1980s, prevailing view among researchers was that life span of any organism, even yeast, could not be regulated, let alone by just a few genes. The based on fact aging is an incredibly complex process affected thousands Then, in years, genetic studies model organisms such as Saccharomyces cerevisiae and Caenorhabditis elegans uncovered numerous single-gene mutations extend (Jazwinski et al. 1993; Kenyon Kennedy 1995). What had overlooked prior to 1990? major oversight appears...
The Orchidaceae is one of the largest and most diverse families flowering plants.The Dendrobium genus has high economic potential as ornamental plants for medicinal purposes.In addition, species this are able to produce large crops.However, many varieties very similar in outward appearance, making it difficult distinguish from another.This study demonstrated that 12 used may be divided into 2 groups by internal transcribed spacer (ITS) sequence analysis.Red yellow flowers also separate these...
Our two labs and others have shown that SIR2 controls the life span of diverse species, including Saccharomyces cerevisiae Drosophila melanogaster, deleting blocks life-span extension by calorie restriction. The methods Kaeberlein et al . allow yeast to bypass requirement for its homologs, which brings into question their suitability modeling physiology more complex organisms.
NAD+ is an essential metabolite participating in cellular biochemical processes and signaling. The regulation interconnection among multiple biosynthesis pathways are incompletely understood. Yeast (Saccharomyces cerevisiae) cells lacking the N-terminal (Nt) protein acetyltransferase complex NatB exhibit approximate 50% reduction levels aberrant metabolism of precursors, changes that associated with a decrease nicotinamide mononucleotide adenylyltransferase (Nmnat) levels. Here, we show this...
NAD+ is a cellular redox cofactor involved in many essential processes. The regulation of metabolism and the signaling networks reciprocally interacting with NAD+-producing metabolic pathways are not yet fully understood. NAD+-dependent histone deacetylase (HDAC) Hst1 has been shown to inhibit de novo synthesis by repressing biosynthesis nicotinic acid (BNA) gene expression. Here, we alternatively identify HDAC Rpd3 as positive regulator budding yeast Saccharomyces cerevisiae. We reveal that...
BACKGROUND: Chronic kidney disease (CKD) is an important and noteworthy health issue worldwide. It especially a problem in Taiwan because of its high prevalence incidence. Metabolic syndrome associated with CKD, but the mechanisms underlying this association have not been determined. In view this, we evaluated relationship between CKD metabolic beyond components characteristics Taiwanese adults aged 40 years above.METHODS: From January 2002 to December 2006, conducted community-based medical...
HLA-A, B and C phenotypes gene frequencies of Chinese living in Taiwan are presented. Cw1 Cw3 were frequently found to segregate together on the same haplotype.
Nicotinamide adenine dinucleotide (NAD+) is a critical cofactor essential for various cellular processes. Abnormalities in NAD+ metabolism have also been associated with number of metabolic disorders. The regulation and interconnection pathways are not yet completely understood. By employing an intermediate-specific genetic system established the model organism S. cerevisiae, we show that histone deacetylases (HDACs) Hst1 Rpd3 link de novo metabolism-mediating BNA genes certain aspects...
Radix of Pueraria spp. is a popular traditional Chinese medicine. There are two major species in Taiwan, i.e., montana and lobata. The constituents Puerariae radix were isoflavonoids, which include puerarin, daidzin, genistin, genistein, daidzein daidzein-4', 7- diglucoside. This study developed simultaneous analysis multi-component HPLC method to determine the six components isoflavonoids root, vine, leaf, petiole parts P. lobata for establishing standard quality control Results showed that...
ABSTRACT NAD + is an essential metabolite participating in cellular biochemical processes and signaling. The regulation interconnection among multiple biosynthesis pathways are not completely understood. We previously identified the N-terminal (Nt) protein acetyltransferase complex NatB as a homeostasis factor. Cells lacking show approximate 50% reduction level aberrant metabolism of precursors, which associated with decrease nicotinamide mononucleotide adenylyltransferases (Nmnat) levels....