A5001028913- Chemical Synthesis and Analysis
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Click Chemistry and Applications
- Advanced Polymer Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Molecular Junctions and Nanostructures
- Ferrocene Chemistry and Applications
- Biochemical and Structural Characterization
- biodegradable polymer synthesis and properties
- Supramolecular Chemistry and Complexes
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Curcumin's Biomedical Applications
University of Würzburg
2015-2019
TU Dresden
2013
Abstract A known limitation of polymer micelles for the formulation hydrophobic drugs is their low loading capacity ( LC ), which rarely exceeds 20 wt%. One general strategy to overcome this increase amphiphilic contrast, that is, make core more hydrophobic. However, in case poly(2‐oxazoline) (POx)‐based triblock copolymers, a minimal contrast was reported be beneficial. Here, subject revisited detail using long side chains are either linear (nonyl) or branched (3‐ethylheptyl). Two different...
Abstract The nucleophilic living ring‐opening polymerization of N‐substituted glycine N‐carboxyanhydrides using solid‐phase synthesis resins is reported. By variation experimental parameters, products with near Poisson distributions are obtained. As opposed to reversible deactivation radical polymerization, the demonstrated be viable high monomer conversion and through multiple addition steps. Successful preparation a multiblock copolypeptoid proof for highly robust character peptoid...
The highly modular Ugi four-component reaction (Ugi-4CR) was used to directly obtain polymers of high molar mass bearing aromatic residues in the backbone. By using at least two bifunctional monomers, Ugi-4CR can be employed synthesize through a polycondensation under mild conditions absence catalysts. This versatile approach allows creation vast libraries molecules by comparably small pool compounds. We investigated six different possible types polymerization (Ugi-4CP) generate polyamides...
Abstract The self‐assembly of block copolymers has captured the interest scientists for many decades because it can induce ordered structures and help to imitate complex found in nature. In contrast proteins, nature's most functional hierarchical structures, conventional polymers are disperse their length distribution. Here, we synthesized hydrophilic hydrophobic polypeptoids via solid‐phase synthesis (uniform) ring‐opening polymerization (disperse). Differential scanning calorimetry...
p.p1 {margin: 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this increase amphiphilic contrast, i.e. make core more hydrophobic. However, we reported earlier that poly(2-oxazoline) based triblock copolymers, a minimal contrast beneficial, was tentatively attributed possible side chain crystallization. Here, revisit subject...
p.p1 {margin: 0.0px 0.0px; font: 11.0px Helvetica} A known limitation of polymer micelles for the formulation hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this increase amphiphilic contrast, i.e. make core more hydrophobic. However, we reported earlier that poly(2-oxazoline) based triblock copolymers, a minimal contrast beneficial, was tentatively attributed possible side chain crystallization. Here, revisit subject in detail...