A method for performing noninvasive blood glucose measurements was developed. The is based on mid-infrared absorption spectroscopy and uses only a few wavenumbers to measure levels in vivo unconditionally. We found that the regression of using three wavenumbers, which were selected series cross-validation technique, realized accuracies comparable those cases greater number are used. In addition, we demonstrated performance this model through correlations among different types data.

A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using brought about higher sensitivity, the flat wide contact surface of resulted in measurement reproducibility. An analysis vivo measurements human inner lip mucosa revealed clear signatures difference spectra between ones taken during fasting state after ingestion solutions. calibration plot...

A mid-infrared spectroscopic system using a high-speed wavelength-swept and pulsed quantum cascade laser (QCL) for healthcare applications such as blood glucose measurement is proposed. We developed an attenuated total reflection comprising the QCL with micro-electromechanical (MEMS)-scanning grating, hollow optical fibers, InAsSb detector tested its feasibility applications. continuous spectrum was obtained by integrating comb-shaped spectra, timing of which slightly shifted. As this method...

Abstract Background Glioma is a primary brain tumor and the assessment of its molecular profile in minimally invasive manner important determining treatment strategies. Among abnormalities gliomas, mutations isocitrate dehydrogenase (IDH) gene are strong predictors sensitivity prognosis. In this study, we attempted to non-invasively diagnose glioma development presence IDH using multivariate analysis plasma mid-infrared absorption spectra for comprehensive sensitive view changes blood...

An area of 3 × 4 m 2 is covered by 48 plastic scintillators above and below a water tank in depth. From maps the charged-particle density energy-flow core region, properties EAS cores high-energy nucleon component have been studied. About 25% observed show complicated structure "multiple core". These can be understood as due to effects nuclear particles having large transverse momenta several GeV/c few tens GeV/c. The frequency occurrence such events increases with size only slowly, but it...

A noninvasive glucose monitoring system based on mid-infrared, attenuated total reflection spectroscopy using a hollow optical fiber probe is developed. Owing to the flexible probe, measurement of oral mucosa, where blood capillaries are near skin surface, possible. Blood levels measured by detecting peak intensity absorption bands, and experimental results showed that reproducibility high enough for glucose.

Human breath is a biomarker of body fat metabolism and can be used to diagnose various diseases, such as diabetes. As such, in this paper, vacuum ultraviolet (VUV) spectroscopy system proposed measure the acetone exhaled human breath. A strong absorption peak at 195 nm detected using simple consisting deuterium lamp source, hollow-core fiber gas cell, fiber-coupled compact spectrometer corresponding VUV region. The functions both long-path an extremely small-volume cell; it enables us...

Abstract We developed a photoacoustic spectroscopic method using mid-IR light for non-invasive analysis of blood components in living bodies. The ultra-low-volume cell enabled highly sensitive measurement, and, glucose-containing gel, the spectrum showed an almost linear relationship with absorption spectrum. optimum modulation frequency was determined both theoretically and experimentally spectra glucose gels obtained at different frequencies. human wrist measured same time as levels were...

Hollow optical fiber probes are used for remote Raman and infrared spectroscopy. Preliminary experiments using these performed, the results of show that hollow useful endoscopic measurement As regards to spectroscopy, a probe with ball lens at end works as confocal system. It can, thus, detect molecular structure biotissues high SNR. Owing their small diameter, in vivo noninvasive analysis by flexible endoscope. A hollow-fiber was also Fourier transform spectroscopy form an reflectometry...

A hollow optical-fiber probe for infrared attenuated total reflection (ATR) spectroscopy is developed. newly designed ATR prism, optimized use with optical fibers, proposed. Results from preliminary experiments show the potential uses of in clinical applications. The appropriate vivo applications because it consists only nontoxic and chemically durable materials.

For non-invasive measurement of blood glucose levels, a system based on mid-infrared, attenuated-total-reflection spectroscopy equipped with hollow optical fibers, trapezoidal multi-reflection prism, and two fixed-wavelength quantum cascade lasers emitting different wavelengths is proposed. From the absorption spectra lip mucosa measured by Fourier-transform infrared spectrometry, wavelengths, 1152 cm-1 for 1186 background, were chosen. To reduce errors, power distribution prism surface was...

A spectral imaging system consisting of a Fourier transform-infrared spectrometer, high-speed infrared camera, and bundle hollow-optical fibers transmitting radiation images was constructed. Infrared transmission spectra were obtained by carefully processing multiple interferograms taken photography. variety samples captured the measured. We successfully detected existence maps oil fat biological mapping specific wavelengths in spectrum.

Noninvasive, glucose-monitoring technologies using infrared spectroscopy that have been studied typically require a calibration process involves blood collection, which renders the methods somewhat invasive. We develop truly noninvasive, technique mid-infrared does not collection for by applying domain adaptation (DA) deep neural networks to train model associates glucose concentration with spectral data without requiring training dataset labeled invasive sample measurements. For realizing...

Attenuation lengths for individual EAS passing through a 2 m layer of water have been measured by means two layers plastic scintillators. The attenuation obtained vary over wide range from about 70 g/cm to several hundreds and, very rarely, the negative length growing stage has obtained. observed are not sensitive core structure (single or multiple core), but age parameter determined lateral function. However, there some discrepancies between parameters estimated longitudinal development and...

We optimized the configuration of a hollow-fiber gas cell used in Fourier-transform infrared spectroscopy system for quantitative analyses low-concentration components with small sample volume. Numerical calculation shows that signal-to-noise ratio (SNR) this measurement is maximized condition dependent on fiber's bore size and length, transmission loss fiber, absorption coefficient objective component. From design calculation, hollow optical fiber large diameter 2 mm was chosen, constructed...

The lateral density distribution of charged particles in EAS is one the essential parameters for analysis individual EAS. To measure detail, 100 ¼-m 2 scintillators were arranged a lattice configuration with unit distance 5 m or 2.5 m. conventional array 20 was also used to obtain densities up about from center. These observations are much more accurate than those obtained previously, and it has been found that there various types structure functions which can be approximated by single...

For the non-invasive measurement of biological tissue, a piezoelectric photoacoustic spectroscopy (PZT-PAS) system that detects single frequency ultrasound induced by irradiation pulse-modulated mid-infrared laser light was developed. PA spectra optical phantom and samples were obtained, relationship between signal intensity absorbance in fingerprint region (930–1,200 cm −1 ) analyzed to estimate absorbance. The resonance vibration utilized further increase strength for tissue measurement....

The present study focuses on the theoretical and practical infrared radiation propagation properties of tapered silver / iodide coated Hollow Glass Waveguides (HGWs). Tapered HGWs with inner diameters ranging from 300 μm to 650 a linear taper increasing at an approximate rate 1.5 μm/cm were fabricated optimized for low-loss transmission CO₂ laser 10.6 μm. losses in these are calculated light transmitted big small vice versa. Theoretical calculations used this based ray-optics....

Remote spectroscopy systems based on hollow optical fiber probes are proposed and experimental results using a Fourier transform spectroscope presented. A optical-fiber probe with silver polymer inner coating is used to deliver incoherent light target another separate collect the reflected light. The reflectance spectra of teeth, skin, oral mucosa were successfully measured even from surfaces reflectances lower than 0.5%. preliminary obtained attenuated total reflection also This remote...

For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with combination of QCL as light source and hollow-optical fiber beam delivery medium is developed. Firstly the sensitivity evaluated by using solutions result shows significant correlation between optical absorbance solution concentration. It also confirmed that has enough for measurement. Then absorption human lips in wavelength region measured wavenumber 1080 cm^-1...

Systems for infrared reflectance imaging are built with an FT-IR spectrometer, hollow optical fibers, and a high-speed camera. To obtain images of biological samples, fiber probe equipped light source at the distal end hybrid composed fibers beam radiation ones image detection have been developed. By using these systems, spectral lipid painted on biomedical hard tissue, which provides around 4%, successfully acquired.