A5067785473- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
Southeast University
2022
Huashan Hospital
2022
Shanghai Medical College of Fudan University
2022
The neurobiological understanding of obsessive–compulsive disorder (OCD) includes dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive stereotyped behavior (e.g., grooming), a featured symptom in OCD, has been proposed to be associated with perturbed dopamine (DA) signaling. However, the precise brain circuits participating DA’s control over this behavioral phenotype remain elusive. Here, we identified that DA neurons substantia nigra pars compacta (SNc)...
Abstract Acquired information can be consolidated to remote memory for storage but persists in a dormant state until its retrieval. However, it remains unknown how is reactivated. Using combination of simultaneous two-photon calcium imaging and holographic optogenetics the anterior cingulate cortex (ACC) vivo, we discover subset GABAergic neurons that are specifically associated with These interneurons display persistent activity inter-neuronal synchronization at stage. In absence natural...