A5081338520- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Advanced Sensor and Energy Harvesting Materials
- Neural dynamics and brain function
- Conducting polymers and applications
- Graphene research and applications
- Advanced Materials and Mechanics
- Vagus Nerve Stimulation Research
- Muscle activation and electromyography studies
- Analytical Chemistry and Sensors
- Neurological disorders and treatments
- Advanced Battery Technologies Research
- Electrostatic Discharge in Electronics
- Advanced biosensing and bioanalysis techniques
- Tactile and Sensory Interactions
- Electrochemical Analysis and Applications
- Thermal properties of materials
- Advanced DC-DC Converters
- Carbon Nanotubes in Composites
- Multilevel Inverters and Converters
- Graphene and Nanomaterials Applications
- Atrial Fibrillation Management and Outcomes
- Biosensors and Analytical Detection
Shanghai Jiao Tong University
2018-2024
In this paper, a polyimide-based flexible device that integrates 16 micro-LEDs and IrO x -modified microelectrodes for synchronous photostimulation neural signal recording is presented. The 4 × (dimensions of 220 270 50 μm3, 700 μm pitch) are fixed in the SU-8 fence structure on polyimide substrate connected to leads via wire-bonding method. electrodes share similar fabrication process with microelectrode sites (200 diameter modified by iridium oxide (IrO ). These two subparts can be aligned...
Abstract Implantable brain–computer interface (BCI) devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases. However, traditional implants with rigid or bulky cross-sections cause trauma decrease the quality of neuronal signal. Here, we propose a MEMS-fabricated flexible device for BCI applications. The microdevice thin film substrate can be readily reduced submicron scale low-invasive implantation. An elaborate silicon shuttle improved structure is...
The delicate serpentine structures are widely used in high-performance stretchable electronics over the past decade. metal interconnects encapsulated biocompatible polymer Parylene-C film is a superior choice for long-term implantation vivo, especially as neural interface to acquire electrophysiological signals or apply electrical stimulation. To avoid physical contact damages from tissues such brain peripheral nerves, utilized electrodes and usually bonded soft elastomer substrate. adhesion...
Precision medicine calls for high demand of continuous, closed-loop physiological monitoring and accurate control, especially cardiovascular diseases. Cardiac optogenetics is promising its superiority cell selectivity time-space accuracy, but the efficacy relative to input light stimulus detected controlled separately by discrete instruments in vitro, which suffers from time retardation, energy consumption, poor portability. Thus, a highly integrated system based on implantable sensors...
Abstract Inflammation is a serious symptom of tendon rupture, that leads to peritendinous adhesion and damages the recovery motor function. Although it commonly treated using medical therapy, side effects occur in cardiovascular genitourinary systems. Electrical stimulation (ES) novel alternative neural modulation. However, its inflammatory inhibitory effect around has rarely been investigated. Here, an ultraflexible cuff electrode with thickness only 3.3 µm constructed conformally wrap...
The optoelectrode arrays can modulate the neuron precisely with high time resolution and good reversibility compared to electrical stimulation. However, integrated light-emitting diode (LED) or laser (LD) will introduce noise from surroundings affects signal quality recording by electrodes. Here, we present a polyimide (PI)-based flexible for low-noise neural recording. Compared traditional electrode, this has metal shield between part LED which isolate electromagnetic active devices Poly...
The combination of optical manipulation neural activities with electrophysiology recording is a promising technology for discovering mechanisms brain disorders and mapping networks. However, fiber-based optrode limited by the large size light source winding fiber, which hinders animal's natural movement. Meanwhile, laser diode (LD)-based restricted to stimulation-locked artefacts will contaminate signal acquired from channels.Here, reformative low-noise internal grounded shielding layer...
The input-output function of neural networks is complicated due to the huge number neurons and synapses, some high-density implantable electrophysiology recording tools with a plane structure have been developed for circuit studies in recent years. However, traditional probes are limited by record-only inability monitor multiple-brain regions simultaneously, complete cognition still has long way away. Herein, we develop three-dimensional (3D) drivable optrode array precise optical...
Pulsed field ablation is an emerging technique for the treatment of atrial fibrillation, and it can specifically damage cardiomyocytes without destroying surrounding tissues. However, current single-function electrodes apply electric pulses at thousands volts, which potentially harmful to heart. In this letter, we propose a multifunctional microelectrode low-voltage pulsed effect evaluation. By using finite element analysis tests on potato tissues in vivo experiments, show that soft...
pH value plays an important role in many fields such as chemistry and biology; therefore, rapid accurate measurement is very important. Because of its advantages preparation, wide test range, response, good biocompatibility, iridium oxide material has received more attention. In this paper, we present a method for preparing microelectrodes based on the sputter deposition method. The sputtering parameters are also studied optimized. Open-circuit potential tests show that exhibit...
Flexible sheet electrode can record electrocorticography signals without penetrating the blood-brain barrier. However, attachment between cortex and influences quality of signal directly. Here, we present a 3-D ultrathin bioelectrode with elastic sites to achieve conformal coverage on brain tissue increase flexibility electrode. Inspired by kirigami, micro-warping structures conformality significantly when compared conventional planar electrodes. It has been proved that warping structure an...
This paper reports on a flexible and stretchable neural probe based polyimide (PI) which has excellent robustness biocompatibility. For the first time, kirigami structure is designed in substrate, composite Young's modulus of decreases from 2.5Gpa to 2KPa will enhance adaptability micromotion brain tissue. Hundreds cyclic stretching tests verified flexibility effectiveness probe. In addition, it been proved vitro that can be easily implanted into tissue by steel needle.
Signal recording and stimulation with high spatial temporal resolution are of increasing interest the development implantable brain-computer interfaces (BCIs). However, BCI technology still faces challenges in biocompatibility long-term stability devices after implantation. Due to cone structure, needle electrodes have advantages as nerve electrodes. This paper develops fabrication Ag micro/nano a laser-assisted pulling method modifies electrode surface by electrochemical oxidation. A...
This paper reports a unique fabrication method to obtain wrinkled microelectrodes with different surface morphologies based on hyperelastic substrates for the first time. The wrinkle microstructures are enhanced by mixture silicone oil in uncured poly (dimethyl siloxane) (PDMS) or Ecoflex polymer followed oil-extraction chloroform and depositing 5 μm Parylene-C film. amplitude of oil-pretreated PDMS top layer show 5-fold 125-fold increase than unpretreated ones, respectively. Besides, 3D...
This paper presents a flexible multi-shanks omini-directional neural probe array. The includes eight shanks with different length, each shank contains 128 recording sites. Traditional Multilayer lithography is applied to fabricate the and novel stacked structure design four-sided electrodes (32 sites on surface 96 sidewall) proposed in this multi-shank array, which increases electrode density of integration can be readily scaled up 1024 channels. It has been proved that impedance at 1 kHz...
Cuff electrodes have been widely utilized on peripheral nerve for neural stimulation and recording applications. In this paper, we proposed a self-rolling meshed cuff electrode induced by the thermal strain. The final diameter is about 1.4 mm, which can match well with of rat (diameter 1.54 mm at ischial tuberosity sciatic nerve). mechanical simulation mesh illustrates oblivious change from plane when bending model. not only facilities flow interstitial fluid in out, but also shows potential...
Stretchable electrodes based on elastomer like Polydimethylsiloxane (PDMS) have been utilized as the more conformal interface with soft tissues in recent years, but most connection methods between stretchable and flexible flat cable (FFC) are time-consuming unreliable, such printing conductive paste bonding pads or clamping this area to connector. In work, efficient thermocompression aid of thermal release tape is developed, high yield achieved before after stretching 20%. This method...
Abstract The zero-voltage switching (ZVS) phase-shifted full-bridge (PSFB) converter has the advantages of simple circuit topology, low voltage and current stress, controllable working frequency. If applied to dc charging pile, it can effectively reduce loss improve overall operating efficiency power supply system. principle ZVS PSFB is analyzed, main topology determined by combining with technical specifications required pile. Based on PI control, wide range output realized. Finally, PSIM...