Thomas Isbrandt

ORCID: 0000-0003-3938-0816
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Research Areas
  • Microbial Metabolism and Applications
  • Fungal Biology and Applications
  • Microbial Natural Products and Biosynthesis
  • Advanced battery technologies research
  • Legume Nitrogen Fixing Symbiosis
  • Electrocatalysts for Energy Conversion
  • Plant Stress Responses and Tolerance
  • Microbial Fuel Cells and Bioremediation
  • Mycotoxins in Agriculture and Food
  • Chemistry and Chemical Engineering
  • Electrochemical Analysis and Applications
  • Supercapacitor Materials and Fabrication
  • Phytochemical Studies and Bioactivities
  • Glycosylation and Glycoproteins Research
  • Cancer therapeutics and mechanisms
  • Biochemical and biochemical processes
  • Biodiesel Production and Applications
  • Tuberculosis Research and Epidemiology
  • Fungal and yeast genetics research
  • Plant nutrient uptake and metabolism
  • Chromatography in Natural Products
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Plant Disease Resistance and Genetics
  • ATP Synthase and ATPases Research
  • Photosynthetic Processes and Mechanisms

Technical University of Denmark
2012-2023

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as oryzae, used in food fermentation enzyme production, flavus, spoiler mycotoxin producer. Here, we sequence 19 genomes spanning section compare 31 fungal including 23 species. We reassess their phylogenetic relationships show that the closest relative of A. oryzae is not but minisclerotigenes or aflatoxiformans identify high genome diversity, especially sub-telomeric regions. predict abundant CAZymes (598 per...

10.1038/s41467-019-14051-y article EN cc-by Nature Communications 2020-02-27

Summary Pathogenic fungi often target the plant plasma membrane (PM) H + ‐ATPase during infection. To identify pathogenic compounds targeting ‐ATPases, we screened extracts from 10 Stemphylium species for their effect on activity. We identified loti as potential inhibitors, and through chemical separation analysis, tenuazonic acid (TeA) a potent inhibitor. By assaying ATP hydrolysis pumping, confirmed TeA inhibitor both in vitro vivo . visualize planta inhibition of ‐ATPase, treated...

10.1111/nph.16398 article EN cc-by-nc New Phytologist 2019-12-27

Abstract Aqueous organic redox flow batteries (AORFBs) have gained increased interest as a promising solution to store energy from sustainable sources. Inspired by naturally occurring bio‐quinones, we here propose new electrolyte based on the fungal compound phoenicin. Phoenicin was produced using filamentous fungus Penicillium atrosanguineum at concentration of 1.24 g L −1 liquid medium and extracted ethyl acetate purity exceeding 95 %. The may provide benefit high scalability...

10.1002/batt.202200365 article EN cc-by-nc-nd Batteries & Supercaps 2022-10-10

Deciphering the cues that stimulate microorganisms to produce their full secondary metabolic potential promises speed up discovery of novel drugs. Ecology-relevant conditions, including carbon-source(s) and microbial interactions, are important effectors metabolite production. Vice versa metabolites mediators in although exact natural functions not always completely understood. In this study, we investigated effects interactions in-culture produced antibiotics on production by Vibrio...

10.1093/femsec/fiab041 article EN FEMS Microbiology Ecology 2021-03-05

Society faces the challenge of storing energy from sustainable sources in inexpensive, nontoxic ways that do not deplete limited resources Earth. In this regard, quinone redox flow batteries have been proposed as ideal; however, industrially used quinones traditionally synthesized fossil fuels. Therefore, we investigated production phoenicin (compound 1), a deep violet dibenzoquinone produced by certain Penicillium species, for its industrial potential. Strains grew surface cultures on...

10.1128/aem.00302-22 article EN Applied and Environmental Microbiology 2022-06-07

Because of their ability to promote growth, act as biopesticides, and improve abiotic stress tolerance, Trichoderma spp. have been used for plant seed coating. However, the mechanism promotion growth remains unknown. In this study, we investigate effect fungal extracts on plasma membrane (PM) H+-ATPase, which is essential often a target plant-associated microbes. We show that harzianum extract increases H+-ATPase activity, by fractionation high-resolution mass spectrometry (MS), identify...

10.1021/acsomega.3c04299 article EN cc-by-nc-nd ACS Omega 2023-09-14

The use of naturally occurring quinones to produce more sustainable electrolytes for renewable energy storage in redox flow batteries (RFBs) is still a new and rarely investigated subject. In this study, we demonstrate how the putative phoenicin its dimer (diphoenicin) influence capacity performance as negolyte battery. To do this, biosynthesized by cultivating filamentous fungus Penicillium phoeniceum resulting fungal extract contained multiple metabolites, putatively related phoenicin,...

10.1021/acssuschemeng.3c02136 article EN ACS Sustainable Chemistry & Engineering 2023-06-08

Abstract Since the initial discovery of a mobilized colistin resistance gene (mcr-1), several other variants have been reported, some which might circulated while before being discovered. Metagenomic data provides an opportunity to re-analyze available older understand evolutionary history recently discovered antimicrobial genes (ARGs). Here, we present large-scale metagenomic study 442 Tbp sequencing reads from 214,095 samples identify host and geographical distribution genomic context nine...

10.21203/rs.3.rs-640935/v2 preprint EN cc-by Research Square (Research Square) 2022-01-12

INTRODUCTION The study present a new way to produce 2nd generation biodiesel as Fatty Acid Methyl Ester (FAME) made from meat industry waste. is produced from sustainable sources like agricultural residues or other waste products biomass. Compared 1st it much more environmentally friendly since does not take up farmland that could otherwise have been used for growing edible crops such as grains. Industrial methods FAME production uses inorganic bases cannot be reused and generates huge...

10.4122/dtu:180 article EN GRØN DYST 2012 2012-06-22
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