Bone marrow (BM) metastasis of breast cancer (BC) can recur even decades after initial diagnosis and treatment, implying the long-term survival disseminated cells in a dormant state. Here we investigated role microRNAs (miRNA) transmitted from BM stroma to BC via gap junctions exosomes tumor cell quiescence. MDA-MB-231 T47D arrest G(0) phase cycle when cocultured with stroma. Analyses miRNA expression profiles identified numerous miRNAs implicated proliferation including miR-127, -197, -222,...

Despite diagnostic advances, breast cancer remains the most prevalent among women in United States. The armamentarium of treatment options for metastatic disease is limited and mostly ineffective with regards to eradicating cancer. However, there have been novel findings recent literature that substantiate function microenvironment progression support metastasis tertiary sites such as bone marrow. uncovered significance pathophysiology has served challenge previously widespread theories...

Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While is well established that ambient oxygen can also cause genomic instability cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level unclear. Herein, by decreasing exposure, we report ∼50% increase median tumor-free survival time of p53−/− mice. In thymus, reducing exposure decreased levels DNA damage RAG recombinase, both which are known promote...

Background: The purpose of this study was to determine the importance factors considered by orthopaedic trauma fellowship applicants when evaluating programs. We hypothesized that will prioritize consistent applying In addition, we assessed how use Internet research potential fellowships. Our goal is provide fellowships with information optimize both their and online contents. Methods: At 2018 2019 Orthopaedic Trauma Association meetings, a paper survey given each attendee multiple...

It is our hypothesis that physician-specific variables affect the management of distal radius (DR) fractures in addition to patient-specific factors.A prospective cohort study was conducted evaluating treatment differences between Certificate Additional Qualification hand surgeons (CAQh) and board-certified orthopaedic who treat patients at level 1 or 2 trauma centers (non-CAQh). After institutional review board approval, 30 DR were selected classified (15 AO/OTA type A B 15 C) create a...

Implantation of adult human mesenchymal stem cells (MSCs) to treat neural disorders shows promise. Depending on their microenvironment, MSCs could potentially be used for the repair and/or replacement neurons in traumatic brain injury or treatment Parkinson's disease. This cross-disciplinary review incorporates aspects neuroscience, cell biology, cancer biology and immunology discuss interactions between inflammatory mediators MSCs. We first role microRNAs (miRNAs) neurological development....

The failed outcome of autologous bone marrow transplantation for breast cancer opens the field investigations. This is particularly important because could be a major source cells during tertiary metastasis. review discusses subsets cells, including those that enter at an early period disease development, perhaps prior to clinical detection. population evades chemotherapeutic damage even high doses. An understanding this might crucial success transplants metastatic and eradication in marrow....

We previously reported that the E6 oncoprotein of high-risk human papillomavirus (HPV) caused genetic instability and oncogenesis by disrupting cellular DNA repair. Here, to investigate effect different domains on double-strand break (DSB) repair, we infected normal oral fibroblasts (NHOF) with retroviruses expressing wild-type (wt) or mutant (mt) HPV-16 examined end-joining (EJ) activity. The cells showed not only a diminution error-free EJ but also an increase in erroneous capacity if...

Objectives: To report the clinical result of a series patients who underwent acetabular fracture fixation using Kocher–Langenbeck approach without specialty traction table. Design: Retrospective case series. Setting: Level 1 trauma center. Patients/Participants: All sustained posterior wall or associated fractures that were treated operatively with over 5-year period. Intervention: Surgical flat, radiolucent Main Outcome Measurements: Outcomes included reduction quality and complications...

The euphoria of stem cell therapy has diminished, allowing scientists, clinicians and the general public to seriously re-examine how what types cells would effectively repair damaged tissue, prevent further tissue damage and/or replace lost cells. Importantly, there is a growing recognition that are substantial person-to-person differences in outcome therapy. Even though small molecule pharmaceuticals have long remained primary focus personalized medicine research, individualized or targeted...

There is significant variability both in how proximal humerus fractures (PHFs) are treated and the ensuing patient outcomes. The purpose of this study was to investigate which surgeon- patient-specific factors contribute decision-making treatment adult PHFs. We hypothesized that orthopedic sub-specialty training creates inherent bias plays an important role management algorithms for PHFs.We performed a prospective cohort investigation 2 groups surgeons-traumatologists (N = 25) shoulder &...

To correlate patient-specific and surgeon-specific factors with outcomes after operative management of distal intra-articular tibia fractures.Retrospective cohort study.3 Level 1 tertiary academic trauma centers.The study included a consecutive series 175 patients OTA/AO 43-C pilon fractures.Primary superficial deep infection. Secondary nonunion, loss articular reduction, implant removal.The following correlated poor surgical outcomes: increased age infection rate ( P < 0.05), smoking...

Introduction The purpose of this study was to describe the outcomes after operative repair ballistic femoral neck fractures. To better highlight devastating nature these injuries, we compared a cohort fractures young, closed, blunt-injury treated with open reduction and internal fixation (ORIF). Methods Retrospective chart review identified all patients presenting at three academic trauma centers between January 2016 December 2021, as well aged ≤50 who received ORIF. primary outcome failure...

Introduction: The goal of this study was to identify the current practices and rationale orthopaedic surgeons regarding venous thromboembolism (VTE) prophylaxis for pelvic acetabular (P&amp;A) fractures. Methods: A 25-item web-based questionnaire made available all Orthopaedic Trauma Association (OTA) members on OTA website. Analysis data performed after three-month period. Results: One hundred three active completed survey. Most respondents practiced at an academic level I trauma centers....

Objective: To determine whether intramedullary nail (IMN) size and its relation to the canal diameter [nail-canal (NC) diameter] impacts union rate or time in treatment of femoral shaft fractures. Design: Retrospective review. Setting: Two Level 1 2 trauma centers. Patients: hundred eighty-seven patients met criteria were included study. Intervention: Patients treated with either an antegrade retrograde IMN. Comparisons first performed comparing 10- versus 11- 13-mm nails. then divided into...