A5020219571- Innovative Teaching Methods
- Various Chemistry Research Topics
- Experimental Learning in Engineering
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Antibiotic Resistance in Bacteria
- Inorganic and Organometallic Chemistry
- Oxidative Organic Chemistry Reactions
- Online and Blended Learning
- Electrochemical Analysis and Applications
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- Catalysis and Oxidation Reactions
- Online Learning and Analytics
- Biomedical and Engineering Education
- Molecular Spectroscopy and Structure
- Chemical Synthesis and Reactions
- COVID-19 diagnosis using AI
- Ubiquitin and proteasome pathways
- Carbohydrate Chemistry and Synthesis
- Teaching and Learning Programming
- Genetics, Bioinformatics, and Biomedical Research
- Chemical Synthesis and Analysis
- Cancer Research and Treatments
- Molecular Junctions and Nanostructures
Centre College
2009-2023
Highland Community College - Illinois
2016
University of Kentucky
2009-2011
Lanzhou University
2010
The University of Texas at Austin
1989-1991
University of Dallas
1985
Butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) are highly homologous proteins with distinct substrate preferences. In this study we compared the active sites of monomers tetramers human BChE AChE after performing molecular dynamics (MD) simulations in water-solvated systems. By comparing conformational gating residues BChE, found that mechanisms main door responsible for their different specificities. Our simulation indicates both enzymes could have two dysfunctional due to...
A mutant of human butyrylcholinesterase (BChE) with high activity against cocaine would be highly promising as a drug for therapeutic treatment abuse and overdose. It is desirable to design recombinant BChE long half-life in circulation. Studies showed that subunits can assembled by peptide containing the proline-rich attachment domain (PRAD) form stable tetramer. The models tetramer complexed PRAD various sequences have been constructed, present study, on basis homology modeling molecular...
In the Just-in-Time Teaching approach, a faculty member assigns readings to students before every class. After have done daily reading, they access short reading quiz using course management system (e.g., Moodle). The uses student responses in preparation of day's class material and is able tailor his or her explanations target specific questions confusion. This paper describes use this approach engage chemistry classes at Centre College. communication summarizes one invited papers ConfChem...
Given that immunoproteasome inhibitors are currently being developed for a variety of potent therapeutic purposes, the unique specificity an α',β'-epoxyketone peptide (UK101) toward LMP2 subunit (analogous to β5 constitutive proteasome) has been investigated in this study first time by employing homology modeling, molecular docking, dynamics simulation, and mechanics Poisson-Boltzmann surface area (MM-PBSA) binding free energy calculations. On basis simulated structures, calculated energies...
This account reports building a community of practice for organic chemistry instructors. With support from Chemistry Collaborations, Workshops, and Communities Scholars (cCWCS), group faculty facilitated multiple workshops to introduce active learning techniques their colleagues across the country. A Web site, organicers.org, has been developed serve as hub aid creating more student-centered environments in classrooms. It serves repository useful materials such questions, exams, syllabi, lab...
Students' active engagement is one of the most critical challenges to any successful learning environment. The blending along with rich, meaningful content necessary for chemical educators re-examine purpose chemistry classroom. Spring 2014 ConfChem conference, Flipped Classroom, was held from May 9 June 12, 2014, and contained 8 papers a poster session discussing variety ways engage students within flipped approach This communication introduces suggests that classroom growing trend, invites...
While cheminformatics skills necessary for dealing with an ever-increasing amount of chemical information are considered important students pursuing STEM careers in the age big data, many schools do not offer a course or alternative training opportunities. This paper presents Cheminformatics Online Chemistry Course (OLCC), which is organized and run by Committee on Computers Chemical Education (CCCE) American Society (ACS)'s Division (CHED). The OLCC highly collaborative teaching project...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry Game ShowsSusan Campbell and Jennifer Muzyka View Author Information Department of Chemistry, Georgetown College, Georgetown, KY 40324 Centre Danville, 40422Cite this: J. Chem. Educ. 2002, 79, 4, 458Publication Date (Web):April 1, 2002Publication History Received3 August 2009Published online1 April 2002Published inissue 1 2002https://pubs.acs.org/doi/10.1021/ed079p458https://doi.org/10.1021/ed079p458research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVTech ReportNEXTVisualization Tools for Organic ChemistryJennifer L. MuzykaView Author Information Department of Chemistry, Centre College, Danville, KY 40422Cite this: J. Chem. Educ. 2009, 86, 2, 254Publication Date (Web):February 1, 2009Publication History Received3 August 2009Published online1 February inissue 1 2009https://pubs.acs.org/doi/10.1021/ed086p254https://doi.org/10.1021/ed086p254product-reviewACS Publications. This publication is available under...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective photoelectrochemical oxidation of vicinal cyclohexanedicarboxylic acids: a mechanistic studyJennifer L. Muzyka and Marye Anne FoxCite this: J. Org. Chem. 1990, 55, 1, 209–215Publication Date (Print):January 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00288a035https://doi.org/10.1021/jo00288a035research-articleACS PublicationsRequest reuse permissionsArticle...
The transition to a remote teaching and learning environment was quick painful at times, yet it experience for everyone. chemists Centre College utilized new (to them) technology reimagine the typical face interactions with students colleagues. From Slack Pear Deck Zoom classrooms, faculty engaged variety of platforms continue learn remotely despite challenges global pandemic. learned value utilizing different types technology, some important skills content.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of substituents on the electrochemistry substituted tetraphenylethylenesJennifer L. Muzyka and Marye Anne FoxCite this: J. Org. Chem. 1991, 56, 14, 4549–4552Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a044https://doi.org/10.1021/jo00014a044research-articleACS PublicationsRequest reuse permissionsArticle...
Student success in both general chemistry and upper-level courses requires the application of previously learned skills for carrying out calculations exercises problem solving. Students with weaknesses mathematics often struggle their courses. The Fall 2017 ConfChem conference, Mathematics Undergraduate Chemistry Instruction, was held from October 26 through November 27, 2017, contained eight papers that discussed a variety approaches developed by instructors to facilitate student using This...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMaking Student-Acquired Spectra Available via a Web BrowserLucas W. Hatcher , Ian M. Kaster and Jennifer L. Muzyka View Author Information Department of Computer Science, Centre College, Danville, KY 40422 Departments Chemistry Chemistry, 40422Cite this: J. Chem. Educ. 2007, 84, 11, 1871Publication Date (Web):November 1, 2007Publication History Received3 August 2009Published online1 November 2007Published inissue 1...
The widespread of use antibiotics to treat bacterial infection has selected for antibiotic resistant strains bacteria. Fosfomycin is an example a broad spectrum that become less effective because increased resistance. inhibits synthesis peptidoglycan, structural component the cell wall. covalently binds phosphoenolpyruvate binding site enzyme MurA, essential in peptidoglycan pathway. MurA catalyzes addition enolpyruvate UDP‐N‐acetylglucosamine. additional product, inorganic phosphate,...
Antibiotic resistance necessitates the continuous development of novel inhibitors targeting a variety bacterial pathways. The pathway for synthesis peptidoglycan, necessary component cell wall, is an ideal target antibiotic two reasons: 1) wall prokaryote‐specific structure, and 2) survival. MurA, current study, enzyme that catalyzes first step in peptidoglycan biosynthesis. Our objective to develop competitively bind MurA catalytic sight UDP‐N‐acetylglucosamine. In effort study effects...
SARS-CoV-2 (also known as ) is a coronavirus that has recently emerged and impacted nearly every human on the planet.The nonstructural protein 12 (NSP 12) an RNA-dependent RNA polymerase replicates viral in cell to infect it.Interrupting this function should prohibit virus from replicating within body would decrease severity of virus's effects patients.The objective project identify potential inhibitors for NSP might be suitable antiviral drugs.Thus, we obtained structure RCSB's data...
One of the challenges associated with attending a BCCE (Biennial Conference in Chemical Education) is choosing which talks to attend, because there are often concurrent different symposia participants interested. These conflicts between multiple interests especially challenging for members CCCE (Committee on Computers who organize and workshops. Thus, responsibility presiding their own symposium precludes them from other that interest them. This year, organized four during BCCE. Organizers...