A5044298347- Medical Research and Treatments
- Semiconductor materials and devices
- Optical Network Technologies
- Advancements in Semiconductor Devices and Circuit Design
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer Research and Treatments
- Textile materials and evaluations
- Advanced Photonic Communication Systems
- Hepatitis B Virus Studies
- Photonic and Optical Devices
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Semiconductor Lasers and Optical Devices
- Biomarkers in Disease Mechanisms
- Mechanical Engineering and Vibrations Research
- Inflammation biomarkers and pathways
- Laser-induced spectroscopy and plasma
- Radiation Effects in Electronics
- Simulation and Modeling Applications
- Lung Cancer Diagnosis and Treatment
- Power Line Inspection Robots
- Retinal Development and Disorders
- Robotic Mechanisms and Dynamics
- Laser-Ablation Synthesis of Nanoparticles
- Silicon Nanostructures and Photoluminescence
Stanford University
2018-2024
University of Malaya
2024
Jiangsu Normal University
2014
Shandong University
2010
Ørsted (Denmark)
1981
University of Copenhagen
1981
Abstract The retinal pigment epithelium (RPE) serves vital roles in ocular development and homeostasis but has limited representation large-scale functional genomics datasets. Understanding how common human genetic variants affect RPE gene expression could elucidate the sources of phenotypic variability selected monogenic diseases pinpoint causal genes at genome-wide association study (GWAS) loci. We interrogated genetics cultured fetal (fRPE) cells under two metabolic conditions discovered...
Loss of mitochondrial electron transport complex (ETC) function in the retinal pigment epithelium (RPE) vivo results RPE dedifferentiation and progressive photoreceptor degeneration, has been implicated pathogenesis age-related macular degeneration. Xenogenic expression alternative oxidases mammalian cells tissues mitigates phenotypes arising from some defects, but can exacerbate others. We expressed an oxidase
The erbium ions at energy of 400 keV and dose 5 × 1015 ions/cm2 were implanted into silicon single crystals room temperature the angles 0°, 45° 60°. lateral spread in sample was measured by Rutherford backscattering technique. results show that values good agreement with those obtained from prediction TRIM'98 (Transport Ions Matter) SRIM2006 (Stopping Range codes.
Abstract The eye is an intricate organ with limited representation in large-scale functional genomics datasets. retinal pigment epithelium (RPE) serves vital roles ocular development and homeostasis. We interrogated the genetics of gene expression cultured human fetal RPE (fRPE) cells under two metabolic conditions. Genes disproportionately high fRPE are enriched for genes related to inherited diseases. Variants near these fRPE-selective explain a larger fraction risk both age-related...
Abstract Primary cilia are conserved organelles that integrate extracellular cues into intracellular signals and critical for diverse processes, including cellular development repair responses. Deficits in ciliary function cause multisystemic human diseases known as ciliopathies. In the eye, atrophy of retinal pigment epithelium (RPE) is a common feature many However, roles RPE vivo remain poorly understood. this study, we first found mouse cells only transiently form primary cilia. We then...
【目的】建立简便高效的水稻突变体筛选体系，为克隆参与调控水稻xa/Xa13表达以及xa/Xa13介导的抗／感病和花粉发育信号途径的基因奠定基础。【方法】利用EMS化学诱变携带显性Xa13启动子驱动绿色荧光蛋白（GFP）基因的水稻转基因种质IRBB13（Pxa13：GFP），构建突变群体，分3个时期进行突变体筛选：幼苗期筛选根和芽中绿色荧光减弱或消失的突变体、成株期筛选回复感病表型的突变体和孕穗期筛选育性下降的突变体。【结果】室内检测代M2突变体株系3000个，筛到幼根和幼芽荧光消失的突变体14个，根部荧光正常而芽无荧光的突变体9个。田间试验种植突变体株系3000个，成株期接种PX099初步筛到回复感病表型的突变体株系25个。孕穗期筛选到育性下降且花药中绿色荧光消失的突变体株系7个，其中，包含1个回复感病的突变体株系。【结论】建立了简便高效的筛选水稻突变体筛选体系，结合GFP表达模式异常的突变体、回复感病突变体以及育性下降的突变体分析可判断xa/Xa13参与的水稻抗／感病与花粉发育这2条信号网络途径并不是完全独立的，而是存在一定程度的交叉。